Investigation of intermolecular interactions between amide-amine binary mixtures through dielectric relaxation study

Deshmukh, S. D.; Undre, P. B.; Pattebahadur, K. L.; Mohod, A. G.; Patil, S. S.; Khirade, P. W.

doi:10.1080/00150193.2017.1362280

Cited by 23 publications

(2 citation statements)

References 27 publications

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“…Next, DBAC was produced by a tertiary amine alkylation reaction between BAC and DMAE (Scheme S1), followed by confirmation by 1 H NMR (Figure S2) and FTIR spectroscopy (Figure S3). 30,31 PVDMA (P3) was subjected to postpolymerization modification by DBAC (Scheme 1b), followed by 1 H NMR and FTIR spectroscopy to confirm the conjugation reaction. 1 H NMR confirms the successful functionalization of the azlactone ring of the PVDMA polymer by DBAC (Figure 1a).…”

Section: Functionalization Of Pvdma Polymer With Drug Moleculesmentioning

confidence: 99%

Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release

Mohammad,

Toragall,

Fortenberry

et al. 2024

Biomacromolecules

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Postpolymerization modification of highly defined "scaffold" polymers is a promising approach for overcoming the existing limitations of controlled radical polymerization such as batch-to-batch inconsistencies, accessibility to different monomers, and compatibility with harsh synthesis conditions. Using multiple physicochemical characterization techniques, we demonstrate that poly(2-vinyl-4,4-dimethyl azlactone) (PVDMA) scaffolds can be efficiently modified with a coumarin derivative, doxorubicin, and camptothecin small molecule drugs. Subsequently, we show that coumarin-modified PVDMA has a high cellular biocompatibility and that coumarin derivatives are liberated from the polymer in the intracellular environment for cytosolic accumulation. In addition, we report the pharmacokinetics, biodistribution, and antitumor efficacy of a PVDMA-based polymer for the first time, demonstrating unique accumulation patterns based on the administration route (i.e., intravenous vs oral), efficient tumor uptake, and tumor growth inhibition in 4T1 orthotopic triple negative breast cancer (TNBC) xenografts. This work establishes the utility of PVDMA as a versatile chemical platform for producing polymer-drug conjugates with a tunable, stimuli-responsive delivery.

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Section: Functionalization Of Pvdma Polymer With Drug Moleculesmentioning

confidence: 99%

Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release

Mohammad,

Toragall,

Fortenberry

et al. 2024

Biomacromolecules

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“…The Fourier-transform infrared (FTIR) is a method used to identify the classification of the molecule by knowing its functional group. By using FTIR spectroscopy, we can observe [8][9][10][11][12][13][14][15] that hydrogen interaction between molecules takes place and it is a very interesting class of intermolecular interactions. In the present work, we have revealed the nature of intra and inter molecular interactions between phenol and acetaldehyde molecules in the liquid mixtures with aid of excess thermodynamic properties and Fourier transform infrared spectroscopic (FT-IR) studies.…”

Section: Introductionmentioning

confidence: 99%

Molecular Interaction Studies of Phenol With Acetaldehyde Using Ultrasonic and Ftir Technique

Asghar

Sridhar

Sivakumar

2021

JASR

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The densities ( ), viscosities ( ) and ultrasonic velocities (U) were measured for the binary mixtures of Phenol with Acetaldehyde at 303K.Excess volumes (VmE), isentropic compressibilities (ksE) and isentropic compressibilities (ksE) were determined from these experimental findings. To obtain their coefficients and standard deviations, the excess or deviation properties were based on Redlich-Kister polynomial equation. Depending on the molecular interactions between the components of hetero molecules, the excess or deviation properties were considered either negative, and the nature of liquid mixtures was studied in terms of molecular interactions by steric and electronic effects. The FTIR provides support to thermodynamic studies to classify different interactions between molecules that are unlike them.

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Volumetric, dielectric, and spectroscopic studies for the binary mixtures of glycerol and dimethylacetamide at T= (298.15–323.15) K

Prasad¹,

Manjula²,

Aparna

et al. 2023

Materials Today: Proceedings

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Investigation of intermolecular interactions between amide-amine binary mixtures through dielectric relaxation study

Cited by 23 publications

References 27 publications

Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release

Postpolymerization Modification of Poly(2-vinyl-4,4-dimethyl azlactone) as a Versatile Strategy for Drug Conjugation and Stimuli-Responsive Release

Molecular Interaction Studies of Phenol With Acetaldehyde Using Ultrasonic and Ftir Technique

Volumetric, dielectric, and spectroscopic studies for the binary mixtures of glycerol and dimethylacetamide at T= (298.15–323.15) K

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