Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

Tănase, Corneliu; Berța, Lavinia; Coman, Năstaca Alina; Roșca, Ioana; Man, Adrian; Toma, Felicia; Mocan, Andrei; Jakab-Farkas, László; Bı́ró, D.; Mare, Anca Delia

doi:10.3390/antiox8100459

Cited by 35 publications

(28 citation statements)

References 31 publications

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“…A thorough comparison between the effects of different sizes and shapes on the final properties usually requires the same characteristics of the natural extract used for phytosynthesis. Tanase et al [34] evaluated the antimicrobial potential of different sized Ag NPs (tuned by varying the synthesis pH) against S. aureus, methicillin-resistant S. aureus, E. coli, K. pneumoniae, and P. aeruginosa. In all cases, the the MIC and MBC (minimum bactericidal concentration) were significantly lower for the smaller dimension NPs.…”

Section: Recent Findings In the Morphology-properties Correlationmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

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Section: Recent Findings In the Morphology-properties Correlationmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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“…Based on the literature data, the main objectives of the current study are: Biosynthesis of AgNPs using polyphenolic spruce bark extract (SBE), with a previously developed technique [14,15]; the determination of the influence of different factors on the biosynthesis processes (metallic salt, time and pH); the characterization of biosynthesized AgNPs by specific assays: Ultraviolet-Visible Spectrometry (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), and Transmission Electron Microscopy (TEM); and the evaluation of antioxidant and antibacterial activity for biosynthesized AgNPs.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract

et al. 2019

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Biosynthesized silver nanoparticles (AgNPs) are widely used in Pharmacy and Medicine. In particular, AgNPs synthesized and mediated by plant extracts have shown topossess several biological activities. In the present study, AgNPs were synthesized using Picea abies L. stem bark extract as reducing agent. Factors, such as metal ion solution, pH, and time, which play a role in the AgNPs synthesis, were assessed. The synthesized AgNPs were characterized by Ultraviolet-Visible Spectrometry, Fourier transform infrared spectroscopy, and Transmission Electron Microscopy (TEM). Further, the study has been extended to evaluate the antimicrobial and antioxidant activity of AgNPs. The broad peak obtained at 411–475 nm (UV-Vis spectroscopy), and the color change pattern, confirmed the synthesis of AgNPs. TEM results showed spherical or rarely polygonal AgNPs with an average size of 44 nm at pH = 9. The AgNPs showed antioxidant activity and antibacterial effect against human pathogenic Gram-positive and Gram-negative bacteria. The results show that spruce bark extract is suitable for obtaining AgNPs, with antibacterial and antioxidant activity.

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“…In the timber industry, bark is considered a waste product used for combustion and as garden mulch. Some studies have developed a different process to remove valuable biocompounds from bark in order to produce high-tech, valuable materials [9,10,11]. The bark of woody vascular plants play important roles in plant protection because of their content of bioactive compounds with antimicrobial effects [12].…”

Section: The Bark Of Woody Vascular Plants—a Source Of Phytoconstimentioning

confidence: 99%

“…The bark of woody vascular plants play important roles in plant protection because of their content of bioactive compounds with antimicrobial effects [12]. In a recent study, it was found that bark extracts may be a good source of reducing agents in synthesized metallic NPs [9].…”

Section: The Bark Of Woody Vascular Plants—a Source Of Phytoconstimentioning

confidence: 99%

A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications

et al. 2019

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Nanoparticles are intensely studied because of their importance in diverse fields of biotechnology, especially in medicine. This paper highlights that waste bark can be a cheap source of biocompounds, with high recovery and functionalization potential in nanoparticle synthesis. Due to their biocompatibility and activity as antioxidant, antimicrobial, and anticancer agents, the green synthesis of metallic nanoparticles is of great importance. This review aims to bring together the diversity of synthesized metallic nanoparticles mediated by bark extracts obtained from different woody vascular plants, the phytoconstituents responsible for the reduction of metal salts, and the activity of metallic nanoparticles as diverse agents in combating the microbial, oxidant, and cancer activity. The literature data highlight the fact that metallic nanoparticles obtained from natural compounds are proven reducing agents with multiple activities. Thus, the activity of natural components in environmental protection and human health is confirmed.

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Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

Cited by 35 publications

References 31 publications

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract

A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications

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