Investigation of Immunomodulation Activity in the Leaves of Dalbergia dissoo

Abstract

During the proper functioning of the immune system reactive oxygen or nitrogen species are generated. These can affect by inducing oxidative damage. This condition occurs with ageing and with diseases. This condition can be annihilated by introducing the defaces by antioxidants. Dietary supplementation with antioxidants can prove to be a stepping stone in these conditions. Natural compounds from plants having rich sources of antioxidants can act as immunomodulators. Aim:The aim of the present study is to investigate the immunomodulation activity in the extracts of Dalbergia Sissoo leaves. This includes in vitro testing of D. Sissoo leaves methanolic extract for its antioxidant activity and phytochemicals. Material and methods:The leaves of D. Sissoo are collected from a Sai nursery situated near Manisha market in Bhopal. These leaves were then washed and the disinfected and were then shade dried for 2 weeks and then grinded in the grinder. After grinding these were taken for extraction. The extraction was done by Soxhlet Method. The tests for antioxidant activity includes DPPH Scavenging activity, NO Scavenging activity, total antioxidant activity and phytochemical tests were performed according to standard methods as proposed by Harborne. Results and conclusion:The extract have excellent amount of flavonoids and phenolic contents which agrees to the rich antioxidant activity in the leaves extract. Various photochemical are also present in the extract. It is found that these leaves extract are excellent source of antioxidants and can be used as potent immunomodulator.

A phytochemical and pharmacological review on Dalbergia sissoo: A potential medicinal plant

“…Traditional healers utilize bark the most. The roots' bark has antidiarrheal properties, and inhaling their smoke may cure both bronchitis and migraines [6] .…”