2008
DOI: 10.1016/j.jns.2007.08.010
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Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis

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Cited by 55 publications
(38 citation statements)
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References 28 publications
(47 reference statements)
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“…Evidence from clinical studies of TLE cohorts and follow up studies of children with febrile seizures suggests that prolonged or complex febrile seizures are primarily associated with the subsequent development of TLE (7). Latent infections by herpes viruses may have some infl uence on cases of HS with mesial temporal lobe epilepsy, and the activity of the latent virus in patients with HS should be more extensively studied to establish its role in active infection (15). None of our twins had febrile seizures or a history of meningitis/encephalitis during childhood.…”
Section: Discussionmentioning
confidence: 99%
“…Evidence from clinical studies of TLE cohorts and follow up studies of children with febrile seizures suggests that prolonged or complex febrile seizures are primarily associated with the subsequent development of TLE (7). Latent infections by herpes viruses may have some infl uence on cases of HS with mesial temporal lobe epilepsy, and the activity of the latent virus in patients with HS should be more extensively studied to establish its role in active infection (15). None of our twins had febrile seizures or a history of meningitis/encephalitis during childhood.…”
Section: Discussionmentioning
confidence: 99%
“…The assay conditions, primers, and probes for each virus have been described elsewhere. [13][14][15][16] For haemagglutinin inhibition (HI) tests, H6N1 virus (A/Taiwan/2/2013 isolated from the patient) was used as the antigen to test for specifi c antibodies. The HI tests were done in accordance with procedures described elsewhere.…”
Section: Methodsmentioning
confidence: 99%
“…Several PCR studies of tissue removed during temporal lobectomy from patients with mesial temporal lobe epilepsy have examined the potential etiologic role of HHV6 (47)(48)(49)(50)(51)(52). Results have been variable (Table 2).…”
Section: Human Herpes Virus 6bmentioning
confidence: 99%