Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol–induced hepatotoxicity in rats

Kiran, P Madhu; Raju, A Vijaya; Rao, Battu Ganga

doi:10.1016/s2221-1691(12)60055-0

Cited by 77 publications

(32 citation statements)

References 21 publications

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“…The dose of APAP was selected based on Kiran et al [19]. Twenty-four hours after the APAP ingestion, the rats in PML and PMH groups were received P. major extract 1 000 mg/kg and 1 500 mg/kg respectively, and the NAC (900 mg/kg) for the NAC group.…”

Section: Induction Of Liver Toxicity and Tissue Collectionmentioning

confidence: 99%

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hussan

Basah

Yusof

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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A B S T R A C TObjective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

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Section: Induction Of Liver Toxicity and Tissue Collectionmentioning

confidence: 99%

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Hussan

Basah

Yusof

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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“…During respectively. The in-vitro and in-vivo antioxidant activity assay suggest the ability of CEE extract to reduce biological oxidative stress [25]. Hepatoprotective activity of CEE extract may also be acquired by scavenging the free radicals against oxidative stress [26].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Hepatoprotective Potential of <i>Piper chaba</i> Roots against Paracetamol-Induced Liver Injury

Yesmin¹,

Zahan²,

Hossain³

et al. 2019

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Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. Hepatoprotective effects were demonstrated by significant alteration of serum biomarker enzymes and antioxidant enzymes. Co-administration of P. chaba extract to paracetamol-induced rats resulted in a partial recovery in the serum biochemical parameters (SGOT, SGPT, ALP and Bilirubin). However, ethanolic extract of Piper chaba at lower dose (200 mg/kg b.w.) was more effective than the higher dose 400 mg/kg b.w. in reducing serum dysfunction biomarker enzymes. The histopathological studies of liver tissues also showed better hepatoprotective activity of Piper chaba roots at the lower dose (200 mg/kg b.w.). Paracetamol induced hepatotoxicity in rats resulted in increase of antioxidant enzyme activities such as catalase, super oxide dismutase. The scavenging activity of P. chaba extract was moderate when compared with standard catechin and the IC 50 values of P. chaba and standard catechin were 1.563 ± 0.70 and 3.125 ± 0.676, respectively in DPPH radical scavenging assay. The total antioxidant potential of P. chaba was concentration dependent and revealed promising antioxidant activity as compared to the reference standard catechin. At a concentration of 100 µg/mL the absorbance of P. chaba extract and catechin were 0.430 and 0.746 respectively. The research result indicated that P. chaba extract has protective effects on paracetamol induced oxidative stress and liver damage.

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“…[20] showed that the aqueous extract L. nepetifolia, given as chronic post-treatment, protected against CCl 4 -induced hepatic damage in rats in a similar manner. Additionally, several studies have shown that the methanol and aqueous extracts of some medicinal plants protect against APAPinduced hepatotoxicity by abrogating the drug-induced increase in liver enzymes and maintaining normal liver morphology [21][22][23][24]. Several studies have identified antioxidant phytochemicals, such as polyphenols and flavonoids, which were suggested to be responsible for the medicinal plants' protective properties against APAP-induced hepatic injury [25][26][27][28].…”

Section: Pre-treatment and Post-treatment Effects Of Extracts On Hepamentioning

confidence: 99%

Leonotis nepetifolia Protects against Acetaminophen-Induced Hepatotoxicity: Histological Studies and the Role of Antioxidant Enzymes

AF¹,

YN²

2016

Nat Prod Chem Res

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Aim of the study: High dose acetaminophen (APAP) increases the risk of liver injury caused by oxidative stress due to accumulation of reactive species. Although N-acetyl cysteine is the standard antidote used to treat acute APAPinduced liver failure, we proposed that known antioxidant phytochemicals in Leonotis nepetifolia extracts would protect against APAP-induced hepatic injury by modulating the activities of antioxidant enzymes. Materials and methods:Methanol and aqueous extracts of L. nepetifolia were orally administered in doses ranging (250 mg/kg to 1000 mg/kg) as pre-and post-treatment with high dose APAP (550 mg/kg) to Swiss albino mice. Twenty-four hours after the final dose, animals were euthanized and blood and liver collected for liver enzymes (ALT and AST), histological assessment and antioxidant enzyme assays.Results: Methanol and aqueous extracts as pre-treatment and post-treatment protected against hepatic injury. Extracts abrogated the 14-fold and 4-fold APAP-induced increases in ALT and AST respectively, including histopathological damage (p<0.05). Extracts reversed APAP-induced 4-fold and 14-fold increases in GR and SOD activities respectively (p<0.05). Additionally, extracts reversed APAP-induced decline in GPx activity; particularly the aqueous extract as pre-treatment increased GPx activity up to 2.2-fold over saline-treated controls (p<0.05). Conclusions:Extracts, as pre-treatment and post-treatment, prevented APAP-induced hepatic injury by modulating the activities of antioxidant enzymes. Of particular interest, is the reversal of APAP-induced decrease in GPx activity and increase in SOD activity? Extract-induced increase in GPx activity would facilitate the scavenging of hydroperoxide and peroxide reactive species generated by high dose APAP. We propose that antioxidant phytochemicals in L. nepetifolia may be acting as free radical scavengers which results in reduced SOD activity.

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Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol–induced hepatotoxicity in rats

Abstract: The methanolic extract of leaves of C. gigantea at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats.

Cited by 77 publications

References 21 publications

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Antioxidant Activity and Hepatoprotective Potential of <i>Piper chaba</i> Roots against Paracetamol-Induced Liver Injury

Leonotis nepetifolia Protects against Acetaminophen-Induced Hepatotoxicity: Histological Studies and the Role of Antioxidant Enzymes

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Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol–induced hepatotoxicity in rats

Abstract: The methanolic extract of leaves of C. gigantea at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats.

Cited by 77 publications

References 21 publications

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Antioxidant Activity and Hepatoprotective Potential of &lt;i&gt;Piper chaba&lt;/i&gt; Roots against Paracetamol-Induced Liver Injury

Leonotis nepetifolia Protects against Acetaminophen-Induced Hepatotoxicity: Histological Studies and the Role of Antioxidant Enzymes

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Antioxidant Activity and Hepatoprotective Potential of <i>Piper chaba</i> Roots against Paracetamol-Induced Liver Injury