Investigation of Helicobacter pylori in bronchoscopic lung specimens of young male patients with bronchiectasis but without gastrointestinal symptoms

İlvan, Ahmet; Ozturkeri, H.; Capraz, Firuz; Çermik, Hakan; Kunter, Erdoğan

doi:10.1111/j.1198-743x.2004.00868.x

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…The discrepancy between HP seroprevalence as shown in the report by Bennett et al [22] and our negative results is in line with findings in other chronic lung diseases [16,27,28,29]. This leads to the hypothesis that HP microaspiration may not be directly involved in the induction or progression of fibrotic lung disease in IPF, but that gastric infection with HP initiates a systemic immune response that has an impact on the pulmonary system in susceptible patients.…”

Section: Discussionsupporting

confidence: 63%

Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies

Kreuter¹,

Kirsten²,

Bahmer³

et al. 2015

Respiration

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Background: Increasing evidence suggests a role of gastro-oesophageal reflux (GER) in idiopathic pulmonary fibrosis (IPF) pathogenesis. Recently, an association between serum Helicobacter pylori (HP) antibody positivity and more severe disease was described, but HP has not been directly analysed in lung tissue so far. Objective: To investigate the presence of HP in the lung tissue of IPF patients. Methods: Two tertiary interstitial lung disease care centre databases were screened for available lung biopsy material from IPF patients. Clinical and radiological data, including presence of GER and antiacid medication, were evaluated. HP-specific PCR was carried out on the IPF lung biopsy specimens. Results: A total of 39 IPF patients were included, of whom 85% were male. The patients' median age was 66 years, their vital capacity was 79% predicted, and their diffusing capacity for carbon monoxide was 53% predicted. In all, 82% of the lung biopsies were surgical and 18% transbronchial. Comorbidities were GER disease in 23% (n = 9), sleep apnoea in 13% (n = 5) and hiatal hernia in 38% of the cases (n = 15). Proton pump inhibitors were prescribed at the time of biopsy in 21% of the cases (n = 9). After a median follow-up of 25 months (range 6-69), there were 1 death, 1 lung transplantation and 8 acute exacerbations without relevant differences between the GER and non-GER subgroups. HP DNA was not detected in any of the lung tissue samples. Conclusion: The fact that no HP DNA was detected in the lung tissues calls into question the proposed relevance of HP to the direct pathogenesis of IPF.

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Section: Discussionsupporting

confidence: 63%

Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies

Kreuter¹,

Kirsten²,

Bahmer³

et al. 2015

Respiration

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“…Consanguinity (present in 95%) and siblings with bronchiectasis or symptoms probably due to bronchiectasis (94%) were significant risk factors in 73 Tunisian children with bronchiectasis [54]. Helicobacter pylori has been thought by some [55] but not by others [56,57] to predispose children to bronchiectasis, possibly through gastro-oesophageal reflux and consequent aspiration. However, Helicobacter pylori had no role in a Turkish study of bronchiectasis [58].…”

Section: Respiratory Infectionmentioning

confidence: 99%

Paediatrics in Berlin

Barbato¹,

Bertuola²,

Kuehni³

et al. 2009

European Respiratory Journal

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The aim of this report is to describe the highlights of the European Respiratory Society annual congress in Berlin, Germany. The best abstracts in asthma and allergy, cystic fibrosis, respiratory infection, paediatric and neonatal intensive care, paediatric investigative techniques (in particular respiratory physiology and bronchoscopy) and respiratory epidemiology are presented and set in the context of the current literature.

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“…A polymerase chain reaction (PCR) study showed H. pylori‐ positive results on sinus specimens from chronic sinusitis patients [82,83], but the low prevalence did not allow to draw a conclusion on possible associations. Other reports pointed out high anti‐ H. pylori seroprevalence in obstructive sleep apnoea patients [84], and a case of pediatric angioedema remission after H. pylori eradication [85], while no H. pylori ‐role emerged in bronchiectasis nor SIDS [86,87].…”

Section: Miscellaneousmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

et al. 2004

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Reports on Helicobacter pylori and extragastric diseases have almost doubled this year compared with last year, bearing witness to the persistent scientific interest in this branch of Helicobacter-related pathology. Data belong increasingly to the area of vascular medicine, as well as hematology, dermatology, pediatrics and other fields. Unfortunately, these studies show overall controversial results, due to the impact of several confounding factors, and to the difficulty of recruiting homogeneous patient populations. Furthermore, many studies continue to be conducted on Helicobacter species other than H. pylori, focusing on animal models of gastroenterological illnesses which may retain strong similarities with human diseases. In this paper, taxonomy, detection and characterisation of Helicobacter spp. will be reviewed, together with the most important data issued this year on other Helicobacters and animal models.

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Investigation of Helicobacter pylori in bronchoscopic lung specimens of young male patients with bronchiectasis but without gastrointestinal symptoms

Cited by 13 publications

References 13 publications

Screening for <b><i>Helicobacter pylori</i></b> in Idiopathic Pulmonary Fibrosis Lung Biopsies

Screening for <b><i>Helicobacter pylori</i></b> in Idiopathic Pulmonary Fibrosis Lung Biopsies

Paediatrics in Berlin

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

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