Investigation of heat and mass transfer behavior of mannitol during vial freeze-drying

Muneeshwaran, M.; Srinivasan, G.; Raja, B.; Wang, Chi-Chuan

doi:10.1007/s10973-021-10635-3

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…Science and advanced methods as well as recent technology have played a prominent role in the production of power 1 , refrigeration and heating 2 , production 3 , applications in medicine 4 , pharmaceutical industries 5 . To operate effectively and functionally of these systems will depends on excellent thermal management systems 6 .…”

Section: Introductionmentioning

confidence: 99%

Heat and mass transfer analysis of assisting and opposing radiative flow conveying ternary hybrid nanofluid over an exponentially stretching surface

Nagaraja,

Khan,

Madhukesh

et al. 2023

Sci Rep

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Access to dependable and environmentally friendly energy sources is critical to a country's economic growth and long-term development. As countries seek greener energy alternatives, the interaction of environmental elements, temperature, and sunlight becomes more critical in utilizing renewable energy sources such as wind and bioenergy. Solar power has received much attention due to extraordinary efficiency advances. under this context, the present work focus on solar radiation and chemical processes in the presence of modified ternary hybrid nanofluids (THNFs) circulating over an exponentially stretched surface in both aiding flow (A-F) and opposing flow (O-F) circumstances. The primary objective of this investigation is to dive into the complicated dynamics of these structures, which are distinguished by complex interactions involving radiation, chemical reactions, and the movement of fluids. We construct reduced ordinary differential equations from the governing equations using suitable similarity transformations, which allows for a more in-depth examination of the liquid's behavior. Numerical simulations using the Runge–Kutta Fehlberg (RKF) approach and shooting techniques are used to understand the underlying difficulties of these reduced equations. The results show that thermal radiation improves heat transmission substantially under O-F circumstances in contrast to A-F conditions. Furthermore, the reaction rate parameter has an exciting connection with concentration levels, with greater rates corresponding to lower concentrations. Furthermore, compared to the O-F scenario, the A-F scenario promotes higher heat transfer in the context of a modified nanofluid. Rising reaction rate and solid fraction volume enhanced mass transfer rate. The rate of thermal distribution in THNFs improves from 0.13 to 20.4% in A-F and 0.16 to 15.06% in O-F case when compared to HNFs. This study has real-world implications in several fields, including developing more efficient solar water heaters, solar thermal generating plants, and energy-saving air conditioners.

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Section: Introductionmentioning

confidence: 99%

Heat and mass transfer analysis of assisting and opposing radiative flow conveying ternary hybrid nanofluid over an exponentially stretching surface

Nagaraja,

Khan,

Madhukesh

et al. 2023

Sci Rep

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“…For example, for the bulk liquid in a vial frozen on the shelf of a freeze dryer, assuming that the frozen sample is cylindrical, then the volume and the total surface area are: where r is the radius of the cylinder, and h is the height of the cylinder. Assuming the container surface has no water permeability, the mass transfer can only occur on or through the top of the frozen sample during freeze-drying (Muneeshwaran et al, 2022), then the effective mass transfer area is independent of the sample height: Therefore, if containers or vials with a fixed diameter are used, the effective surface area for mass transfer is fixed and the effective SA/Vol ratio can be expressed as: In practice, the freeze dryer is often designed with multiple shelves, so the height of the frozen liquid in the container is lower, often limited within 2 cm.…”

Section: Introductionmentioning

confidence: 99%

“…where r is the radius of the cylinder, and h is the height of the cylinder. Assuming the container surface has no water permeability, the mass transfer can only occur on or through the top of the frozen sample during freeze-drying (Muneeshwaran et al, 2022), then the effective mass transfer area is independent of the sample height:…”

Section: Introductionmentioning

confidence: 99%

Accelerated mass transfer from frozen thin films during thin-film freeze-drying

Wang

Kuang

et al. 2022

Preprint

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Freeze-drying, or lyophilization, is widely used to produce pharmaceutical solids from temperature-sensitive materials but the process is time and energy inefficient. Herein, using E. coli as a model live organism, whose viability in dry powders is highly sensitive to the water content in the powders, we demonstrated that the drying rate of thin-film freeze-drying (TFFD) is significantly higher than that of the conventional shelf freeze-drying, likely because the large total surface area from the loosely stacked frozen thin films and the low thickness of the thin films enable faster and more efficient mass transfer during freeze-drying. The highly porous nature and high specific surface area of the thin-film freeze-dried powders may have contributed to the faster mass transfer as well. Moreover, we demonstrated that TFFD can be applied to produce dry powders of E. coli and L. acidophilus with minimum bacterial viability loss (i.e., within one log reduction), and the L. acidophilus dry powder is suitable for intranasal delivery. It is concluded that TFFD technology is promising in addressing the time- and cost-inefficient issue of conventional shelf freeze-drying.

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Analytical study of a moving boundary problem describing sublimation process of a humid porous body with convective heat and mass transfer

Chaurasiya

Jain

Singh

2023

J Therm Anal Calorim

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Investigation of heat and mass transfer behavior of mannitol during vial freeze-drying

Cited by 9 publications

References 30 publications

Heat and mass transfer analysis of assisting and opposing radiative flow conveying ternary hybrid nanofluid over an exponentially stretching surface

Heat and mass transfer analysis of assisting and opposing radiative flow conveying ternary hybrid nanofluid over an exponentially stretching surface

Accelerated mass transfer from frozen thin films during thin-film freeze-drying

Analytical study of a moving boundary problem describing sublimation process of a humid porous body with convective heat and mass transfer

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