Investigation of Haematological and Biochemical Side Effects of Tilmicosin in Healthy New Zealand Rabbits

Altunok, Vahdettin; Yazar, Enver; Elmas, Muammer; Traş, Bünyamin; Baş, Ahmet Levent; Çöl, Ramazan

doi:10.1046/j.1439-0450.2002.00502.x

Cited by 22 publications

(15 citation statements)

References 7 publications

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“…Tilmicosin caused temporary decreases in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell volume concentration (PCV). These obtained results were similar to those recorded after tilmicosin administration and caused statistically significant decrease in RBCs and WBCs counts of rabbits and it achieved at high levels in phagocytes of avian, porcine, and bovine [13, 14]. Also, it was reported that other macrolides might cause similar effect.…”

Section: Discussionsupporting

confidence: 86%

Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken

Elsayed

Elkomy

Aboubakr

et al. 2014

Veterinary Medicine International

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The aim of this study was to determine the blood and tissue concentrations profile and effect of tilmicosin on some hematological and biochemical parameters in broiler chicken. Fifty clinically healthy Hubbard chickens were orally administered 25 mg/kg BW of tilmicosin once daily for 5 consecutive days. Tissue residues of tilmicosin in slaughtered healthy chicken could not be detected by microbiological assay in all tested tissues except in lung (at 96 hours) and liver and kidneys (at 72 hours) after last administration. Tilmicosin caused temporary decrease in the RBCs and WBCs counts and has no effect on hemoglobin (Hb) and packed cell volume concentration (PCV). Also, the effect of tilmicosin on some biochemical parameters was as follows: the concentrations of creatinine, uric acid, electrolytes (sodium, potassium, and calcium), glucose, AST, ALT, ALP, and HDL-cholesterol in the serum of treated chicken did not change in response to the repeated oral administration of tilmicosin. There were only a temporary significant decrease in total protein and albumin concentrations and a significant increase in cholesterol and triglycerides concentrations. Chicken must not be slaughtered before 4 days from the stopping of tilmicosin administration. Tilmicosin makes temporary changes on hematological and biochemical parameters in broiler chicken.

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Section: Discussionsupporting

confidence: 86%

Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken

Elsayed

Elkomy

Aboubakr

et al. 2014

Veterinary Medicine International

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“…However, these changes were within normal limits. Changes within normal limits caused by macrolide antibiotics have been reported previously in experimental studies (Altunok et al, 2002;Yazar et al, 2004).…”

Section: Discussionsupporting

confidence: 71%

Tulathromycin disturbs blood oxidative and coagulation status

Ulutaş²,

Altan³

et al. 2011

Afr. J. Biotechnol.

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The aim of this study was to determine the effect of tulathromycin on serum oxidative status and coagulation factors in rabbits. Tulathromycin was administered to eight rabbits, and blood samples were obtained 0, 1, 5, 10 and 15 days after treatment. Indicators of serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol and -carotene) and coagulation values (antithrombin III, fibrinogen) were measured after tulathromycin treatment. In addition, routine serum biochemical values (creatine kinase-MB, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high density lipoprotein, amylase, total protein, albumin, glucose and calcium), haemacell counts (white and red blood cells) and arterial blood gas parameters (packed cell volume, hemoglobin, pH, partial pressure of carbon dioxide, partial pressure of oxygen, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, sodium and potassium) were also determined. Tulathromycin increased (P < 0.05) the levels of malondialdehyde, nitric oxide and superoxide dismutase activity, and decreased (P < 0.05) the level of antithrombin III. In conclusion, tulathromycin may cause oxidative damage and coagulation disorders during the treatment period.

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“…Additionally, no change was seen in ALP, ALT, AST, GGT, bilirubin and total protein levels in the serum of the rabbits. However, decreases in red and white blood cell counts were observed as side effects (Altunok et al, 2002). The result of a previous study by Yazar et al (2004) showed that administration of tilmicosin at 75 mg/kg in mice caused increased MDA and elevated GSH in the liver without any change in the heart.…”

Section: Discussionmentioning

confidence: 94%

The Possible Protective effect of L‐carnitine on Tilmicosin‐induced Cardiotoxicity in Mice

Kart¹,

Yapar²,

Karapehlivan³

et al. 2007

Journal of Veterinary Medicine Series A

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The protective effect of L-carnitine was investigated against tilmicosin-induced cardiotoxic effects including blood creatine kinase (CK), CK-MB, total sialic acid as well as the alterations in glutathione and malondialdehyde concentrations in mice. Thirty-two Balb/C mice were divided into four groups including group 1 (control), group 2 (L-carnitine, s.c., 500 mg/kg for 5 days), group 3 (tilmicosin, s.c., single dose of 75 mg/kg) and group 4 (L-carnitine plus tilmicosin). Serum CK, CK-MB and malondialdehyde (MDA) levels were significantly (P < 0.05) higher in group 3 compared with those of other groups. Total sialic acid level in group 3 was found to be significantly (P < 0.05) higher than that in groups 1 and 2, as well. Contrary to these results, glutathione level in group 3 was found to be significantly (P < 0.05) lower than that in groups 1 and 2. In group 4, serum CK, CK-MB, MDA and total sialic acid levels were found to be significantly (P < 0.05) lower than those in group 3. These results suggest that tilmicosin is cardiotoxic in mice as evidenced by higher total sialic acid, CK and CK-MB. In addition, tilmicosin caused the decrease in glutathione and increase in MDA levels. However, administration of L-carnitine could ameliorate these adverse toxic effects of tilmicosin in mice.

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Investigation of Haematological and Biochemical Side Effects of Tilmicosin in Healthy New Zealand Rabbits

Cited by 22 publications

References 7 publications

Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken

Tissue Residues, Hematological and Biochemical Effects of Tilmicosin in Broiler Chicken

Tulathromycin disturbs blood oxidative and coagulation status

The Possible Protective effect of L‐carnitine on Tilmicosin‐induced Cardiotoxicity in Mice

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