Investigation of Genotoxicity of Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

Plotnikov, Evgenii; Журавков, С. П.; Gapeyev, A. B.; Plotnikov, V. M.; Martemiyanov, Dmitry

doi:10.4028/www.scientific.net/amr.1040.65

Cited by 10 publications

(7 citation statements)

References 6 publications

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“…This was indirectly confirmed by earlier results of the nanoparticles genotoxic testing and scientific literature (Jena et al, 2012;Plotnikov et al, 2015). Most researchers agree with the opinion that the leading factor of the DNA damage is the oxidative stress induced by the nanoparticles for in vivo and in vitro applications.…”

Section: Discussionsupporting

confidence: 73%

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Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

2017

J App Pharm Sci

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Objective: There is plenty of information dedicated to nanomaterial toxicity, but it is often contradictory. This work presents results of the comparative investigation of silver and gold nanoparticles genotoxicity and genotoxic effect of water medium after the spark dispersion process. Material and methods:The nanoparticles were produced in water by the modified energy-efficient electric spark dispersion method. The comet assay, transmission electron microscopy, DLS spectroscopy and thermal desorption of nitrogen (BET method) were used for the investigation. Results:The silver nanoparticles showed a genotoxic effect which appeared at concentration of 0.03 mg/ml and above. The application of gold nanoparticles did not lead to a significant DNA damage at concentrations range of 0.01 -0.03 mg/ml. However, a notable level of genotoxicity was observed at concentrations of gold nanoparticles about 0.1 mg/ml. Supernatant water medium (with trace of Au and Ag metals) following the spark dispersion process showed no genotoxic action. Conclusion: Accordingly, the testing of the nanoparticles produced by the electric spark dispersion in water revealed more expressed genotoxic effect of silver nanoparticles in comparison with the gold ones.

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Section: Discussionsupporting

confidence: 73%

“…Nowadays, gold and silver nanoparticles are used in a variety of applications, such as bio labeling, catalysis, electrochemistry etc (Perevezentseva et al, 2014). For instance, silver has been widely used for antibacterial purposes since the ancient time (Plotnikov et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

2017

J App Pharm Sci

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“…Nanoparticles have significant antiviral properties but also possess a toxic effect, particularly, genotoxic. [7] Ionic silver have anti-infectious properties. [8] Thus, the development of novel soluble and low-toxic silver drugs looks promising.…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of a Novel Silver-based Complex on Influenza Virus

Silnikov¹,

Plotnikov

2018

Journal of Pharmacology and Pharmacotherapeutics

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The results of the experimental and theoretical studies of the processes of the single particles ignition of the wood biomass of various forms (a cube, a cylinder and a sphere) have been presented. According to the results of the experimental studies, it has been established that the particles form can have a fairly significant effect on the characteristics and conditions of ignition. It has been shown that the wood particles in the form of a sphere are ignited much faster than cylindrical and cubic ones (ignition delay times are less by 56%). Such a tendency is maintained for particles sizes from 1 $ 10 À3 m to 3 $ 10 À3 m. According to the results of the experiments, the mathematical model for ignition of a particle of wet wood biomass has been formulated, taking into account the joint occurrence of the main processes of the thermal preparation (radiation-convective particle heating, evaporation of water, thermal decomposition of the organic part of the fuel, output, ignition and combustion of gaseous pyrolysis products, ignition of the char residue). The formulated system of the nonlinear differential equations in the partial derivatives with the corresponding boundary conditions describes the ignition process in a two-dimensional setting, taking into account the substantial nonuniformity of the temperature field of a wood particle in the induction period. We have taken into account that the evaporation process takes place in the front. Up to the present time, the mathematical models of such a degree of detailing of the physical processes occurring together when igniting wet wood have not been formulated. A comparative analysis of the ignition delay times (t ign) obtained theoretically and experimentally has showed their satisfactory correspondence. As a result of the numerical simulation, the temperature fields in the system "a fuel particle d hightemperature medium" have been obtained, illustrating the high gradients of the temperatures at the moment of ignition. It has been established that it is possible to ignite the water-saturated wood particles before they dry completely. It has been established that the ignition mode of wood particles is possible before they dry completely.

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“…The resulting nanostructured product can be used in designing a new filter system for water purification. Detail process description and confirmation nanoscale size of the materials prepared by this method, are reflected in works [9][10][11] . The aim of this work was to crate and study the physicochemical and sorption properties of new modified sorbents with nanostructured surface based on aluminum and iron, obtained by the electro-dispersion method.…”

Section: Introductionmentioning

confidence: 99%

Water Purification with Natural Sorbents: Effect of Surface Modification with Nano-structured Particles

et al. 2015

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Modified nanostructured sorbents are widely used in water treatment processes. In this work, aluminum and iron particles prepared by electro-spark dispersion have been applied as modifiers. Zeolite samples from "Holinskoe" mineral deposit (Russia, Republic of Buryatia), with a size smaller than 0.1 mm, have been modified with aluminum and iron particles, using a sol-gel process. The properties of the modified materials have been determined by means of sorption test, when removing ions Pb{2+}, Fe{3+} and Cd{2+} from the model solutions in static conditions. Using the method of thermal desorption of nitrogen (BET) it has been shown that increasing the iron content in the samples of nanostructured modified sorbents does not affect the increase in specific surface area and pore volume of the samples. Ions concentrations have been analyzed by stripping voltammetry and photocolorimetry. As a result, modified sorbents revealed a high efficiency sorption of heavy metals

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Investigation of Genotoxicity of Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

Cited by 10 publications

References 6 publications

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

In vitro Effects of a Novel Silver-based Complex on Influenza Virus

Water Purification with Natural Sorbents: Effect of Surface Modification with Nano-structured Particles

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