Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo

Сычева, Л. П.; Vs, Zhurkov; Iurchenko, V V; Даугель-Дауге, Н. О.; Коваленко, М. А.; Krivtsova, E. K.; Дурнев, А. Д.

doi:10.1016/j.mrgentox.2011.07.010

Cited by 137 publications

(85 citation statements)

References 31 publications

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“…However, animals were exposed by daily oral gavage for seven days. Smaller TiO 2 NPs with a size of 33 nm showed similar genotoxic results, even if they additionally increased DNA strand breaks of mouse liver cells and apoptosis in forestomach cells (25 Nevertheless, two studies were clearly negative regarding genotoxicity in vivo. Although single intratracheal instillation of 5 nm TiO 2 NPs caused infl ammatory responses in rats, these NPs did not enhance DNA damage neither after single, nor after repeated exposure.…”

Section: Genotoxic Potential Of Titanium Dioxide Npsmentioning

confidence: 90%

Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Klien

Godnič‐Cvar

2012

Archives of Industrial Hygiene and Toxicology

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With increasing production and application of a variety of nanomaterials (NMs), research on their cytotoxic and genotoxic potential grows, as the exposure to these nano-sized materials may potentially result in adverse health effects. In large part, indications for potential DNA damaging effects of nanoparticles (NPs) originate from inconsistent in vitro studies. To clarify these effects, the implementation of in vivo studies has been emphasised. This paper summarises study results of genotoxic effects of NPs, which are available in the recent literature. They provide indications that some NP types cause both DNA strand breaks and chromosomal damages in experimental animals. Their genotoxic effects, however, do not depend only on particle size, surface modifi cation (particle coating), and exposure route, but also on exposure duration. Currently available animal studies may suggest differing mechanisms (depending on the duration of exposure) by which living organisms react to NP contact. Nevertheless, due to considerable inconsistencies in the recent literature and the lack of standardised test methods -a reliable hazard assessment of NMs is still limited. Therefore, international organisations (e.g. NIOSH) suggest utmost caution when potential exposure of humans to NMs occurs, as long as evidence of their toxicological and genotoxic effect(s) is limited.

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Section: Genotoxic Potential Of Titanium Dioxide Npsmentioning

confidence: 90%

Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Klien

Godnič‐Cvar

2012

Archives of Industrial Hygiene and Toxicology

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“…Bone-marrow cells Genotoxicity, induction of oxidative stress, cytotoxicity [89] Hepatocytes Atrophy and necrosis [90] Myocardium cells Cytotoxicity [91] Renal cells Cytotoxicity [92] Lung fibroblast Genotoxicity, autophagy [12,93] Gold nanoparticles (AuNPs) [49,110] components leading to cytotoxicity or genotoxicity depends on its size. Large particles can induce permanent damage to cell membrane via binding with cellular membrane proteins, whilst small particles can pass through membrane and harm organelles [34] and then, bigger ones can occur in the cytoplasm (mainly in vacuoles) and smaller ones in mitochondria.…”

Section: Hepatocytesmentioning

confidence: 99%

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Jennifer¹,

Wnuk²

2013

JBNB

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Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.

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“…The inflammatory cytokines cascade may cause inflammatory cell chemotaxis and apoptosis, resulting in serious spleen injury (Linglan et al, 2009). The cellular damage and oxidative stress of nanoparticles in the spleenocytes were related to the particle size and chemical compositions of nanoparticles Sycheva et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of N-Acetylcystiene Against Titanium Dioxide Nanoparticles Modulated Immune Responses in Male Albino Rats

Soliman¹

2013

American Journal of Immunology

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The protective effects of N-acetylcysteine (NAC) against orally administered titanium dioxide nanoparticles (TiO2) for 3 months on male albino rats were examined. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg −1 BW), NAC (100 mg kg −1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Blood was assayed for serum changes in GPT, GOT, lipid profiles, cytokines and immunoglobulins profiles. Moreover, spleen was examined for alterations in cytokines expression and histopathology. Administration of TiO2 significantly increased serum levels of GPT, GOT and increased lipid profiles. Administration of NAC to TiO2 rats improved significant changes induced by Tio2 alone. There were an increase in IL-1β and IL-6 secretion in TiO2 administered rats which is normalized by NAC administration. Tio2 administration down regulated IL-8 and IL-10 secretion, while co-administration of rats by NAC together with TiO2 normalized that down regulation. Moreover, TiO2 induced toxicity in spleen that accompanied by a decrease in IgA, IgG and IgM that are normalized by NAC administration. Finally, Tio2 up-regulated IL-1β, IL-6 and TNF-β expression in spleen and NAC administration together with TiO2 normalized cytokines expression. In conclusion, present findings confirmed the protective effect of NAC on TiO2 induced alteration in immune responses in male albino rats.

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Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo

Cited by 137 publications

References 31 publications

Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Genotoxicity of Metal Nanoparticles: Focus on In Vivo Studies

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Protective Effect of N-Acetylcystiene Against Titanium Dioxide Nanoparticles Modulated Immune Responses in Male Albino Rats

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