Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices II

Desai, Saurabh J.; Singh, Praveen; Simonelli, Anthony P.; Higuchi, William I.

doi:10.1002/jps.2600551112

Cited by 117 publications

(29 citation statements)

References 6 publications

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“…The Higuchi model is an empirical model commonly used to describe the release kinetics of drugs from insoluble porous materials [80,81]. It is well established and commonly used for modeling drug release from matrix systems [81,85,86]. The model is based on a square root of a time-dependent process of Fickian diffusion.…”

Section: Resultsmentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

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Aims: Porous silicon (pSi) and poly(L-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug delivery into the human body. The combination of a pliable and soft polymeric material with a hard inorganic porous material of high drug loading capacity may engender improved control over degradation and drug release profiles and be beneficial for the preparation of advanced drug delivery devices and biodegradable implants or scaffolds. Materials & methods: In this work, three different pSi and PLLA composite formats were prepared. The first format involved grafting PLLA from pSi films via surface-initiated ring-opening polymerization (pSi–PLLA [grafted]). The second format involved spin coating a PLLA solution onto oxidized pSi films (pSi–PLLA [spin-coated]) and the third format consisted of a melt-cast PLLA monolith containing dispersed pSi microparticles (pSi–PLLA [monoliths]). The surface characterization of these composites was performed via infrared spectroscopy, scanning electron microscopy, atomic force microscopy and water contact angle measurements. The composite materials were loaded with a model cytotoxic drug, camptothecin (CPT). Drug release from the composites was monitored via fluorimetry and the release profiles of CPT showed distinct characteristics for each of the composites studied. Results: In some cases, controlled CPT release was observed for more than 5 days. The PLLA spin coat on pSi and the PLLA monolith containing pSi microparticles both released a CPT payload in accordance with the Higuchi and Ritger–Peppas release models. Composite materials were also brought into contact with human lens epithelial cells to determine the extent of cytotoxicity. Conclusion: We observed that all the CPT containing materials were highly efficient at releasing bioactive CPT, based on the cytotoxicity data. Original submitted 16 December 2010; Revised submitted 29 September 2011; Published online 6 March 2012

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Section: Resultsmentioning

confidence: 99%

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

et al. 2012

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“…A common method to calculate tortuosity is via the results from dissolution measurements. In this method, the tortuosity is calculated from several parameters related to the dissolution of a molecules from a matrix (Desai et al, 1966;Foster & Parrott, 1990). This approach can result in unrealistic values of more than one thousand (Papadokostaki et al, 1998) or below one (Foster & Parrott, 1990).…”

Section: Connectivity and Tortuosity Of Tissue Engineering Scaffoldmentioning

confidence: 99%

Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds

Chang¹,

Wang²

2011

Regenerative Medicine and Tissue Engineering - Cells and Biomaterials

331

305

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“…The release behavior of VS in the Higuchi model may be square root time dependent, which is often exhibited for some types of formulations, such as plastic, wax matrices, and matrix tablets. 35,45,46 The zero-order model did not seem to adequately fit each preparation. The Weibull model was able to fit the dissolution data of the PEG-DSPE and Chitosan formulation.…”

mentioning

confidence: 88%

The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

Zhang

Chen

Li³

et al. 2016

IJN

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Purpose This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, poly(ethylene glycol)-1,2-distearoyl sn-glycero-3-phosphatidylethanolamine (PEG-DSPE), and poly(ethylene glycol)-poly-lactide- co -glycolide (PEG-PLGA), were evaluated at the same coating molar ratio with the commercial product Marqibo ® (vincristine sulfate liposome injection [VSLI]). Materials and methods VS-loaded liposomes were prepared by a pH gradient method and were then coated with chitosan, PEG-DSPE, or PEG-PLGA. Physicochemical properties, including the morphology, particle size, zeta potential, encapsulation efficiency (EE%), pH, drug loading, and in vitro release, were determined. Preservation stability and pharmacokinetic studies were performed to compare the membrane-coated liposomes with either commercially available liposomes or the VS solution. Results The sphere-like morphology of the vesicles was confirmed by transmission electron microscope. Increased particle size, especially for the chitosan formulation, was observed after the coating process. However, the EE% was ~99.0% with drug loading at 2.0 mg/mL, which did not change after the coating process. The coating of long-circulation materials, except for chitosan, resulted in negatively charged and stable vesicles at physiological pH. The near-zero zeta potential exhibited by the PEG-DSPE formulation leads to a longer circulation lifetime and improved absorption for VS, when compared with the PEG-PLGA formulation. Compared with the commercial product, PEG was responsible for a higher plasma VS concentration and a longer half-life. Conclusion PEG-DSPE coating may be related to better absorption, based on the stability and a pharmacokinetic improvement in the blood circulation time.

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Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices II

Cited by 117 publications

References 6 publications

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Controlled Drug Delivery From Composites of Nanostructured Porous Silicon and Poly( L -Lactide)

Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds

The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate

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