Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices III

Desai, Saurabh J.; Singh, Praveen; Simonelli, Anthony P.; Higuchi, William I.

doi:10.1002/jps.2600551113

Cited by 158 publications

(32 citation statements)

References 3 publications

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“…Where, Q t is the amount of drug released at time t, k 0 is release rate constants for zero-order. The first-order equation [19] (Equation 2) describes systems in which the release is dependent on its concentration (generally seen for water-soluble drugs in the porous matrix).…”

Section: Kinetics Of Drug Releasementioning

confidence: 99%

Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate

Bhardwaj¹,

Gupta²,

Chaurasia³

et al. 2017

IJRDPL

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Purpose of present study involves the development of floating microspheres of metronidazole as a model drug, using the modified solvent diffusion evaporation technique. Eudragit S100 and Eudragis RS100 were used in the different ratio as polymers for development of microspheres. The microspheres were characterized for surface morphology by SEM, yield, buoyancy, incorporation efficiency and micromeritic properties. The in-vitro drug release studies were performed in simulated gastric fluid at pH 1.2. Different kinetic models were also applied on drug release from selected formulations. Stability studies were additionally subjected for optimized formulations. The yield of microspheres was good. Microspheres showed satisfactory flow properties. SEM confirmed the spherical size, perforated smooth surface and a hollow cavity in them. Microspheres exhibited floating properties for more than 10 hours. Stability studies showed no significant change in residual drug content of floating Microspheres.

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Section: Kinetics Of Drug Releasementioning

confidence: 99%

Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate

Bhardwaj¹,

Gupta²,

Chaurasia³

et al. 2017

IJRDPL

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“…17,18 This relation can be used to describe drug dissolution from several types of modified release pharmaceutical dosage forms, as of some transdermal systems 19 and from matrix tablets of water soluble drugs. 20,21 Korsmeyer and Peppas (1984) developed an empirical equation to analyze both Fickian and non-Fickian release of drug from swelling as well as non-swelling polymeric delivery systems. 22 The Hixson-Crowell cube root law (1931) describes the release from systems where there is a change in surface area and diameter of particles or tablets.…”

Section: Drug Release Data Analysismentioning

confidence: 99%

Optimization and in-vitro Evaluation of Poly (lactic acid) /Mesalazine Microspheres as Drug Carriers

Banabid¹,

Ferhat²,

Maiza³

et al. 2017

IJPER

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Purpose: The present study is intended to the preparation and optimization of controlled drug release microparticles based on polylactic acid and Mesalazine. This active ingredient is usually used in the therapy of intestine inflammatory diseases, particularly the Crohn's disease and hemorrhagic recto colitis. Methods: Microencapsulation by simple O/W emulsion solvent evaporation method was used to prepare these formulations. Some of the process variables such as the emulsifier concentration, the polymer concentration, the drug: polymer ratio and stirring speed were varied and the obtained biodegradable microparticles were characterized by FTIR spectroscopy, X-ray diffraction, DSC method and optical microscopy. The drug release was established both in simulated intestinal fluid and distilled water and the data analysis and the release mechanism were investigated on the basis of Higuchi and Korsmeyer-Peppas models. Results: The microparticles' size i.e. the number mean diameter (d10) ranged from 127 to 744 µm and the drug content varied from 12 to 27%. The effect of the selected variables on the microparticles' characteristics (size, morphology and drug release) were exhaustively discussed for the PLA/mesalazine microparticles' optimization. Conclusion: This study showed that the microparticles' morphology depended strongly on the emulsifier concentration and the drug entrapment is related to the initial drug:polymer ratio and polymer concentration.

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“…[26] The first order equation describes the release from systems, where release rate is concentration dependent. [27] According to Higuchi model, the drug release from the insoluble matrix is directly proportional to square root of time and is based on Fickian diffusion. [28] Drug release data obtained were applied to different drug release models to establish the drug release mechanism and kinetics.…”

Section: Release Models and Kineticsmentioning

confidence: 99%

Untitled

Kumaravelrajan¹

2016

AJP

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Introduction: A system that can deliver multidrugs at a controlled rate is very important to the treatment of various chronic diseases such as diabetes, asthma, and hypertension. In general, both highly and poorly water-soluble drugs are not good candidates for elementary osmotic delivery, so in the present investigation nifedipine-hydroxyproyl-β-cyclodextrin (1:1) inclusion complex was used to modulate the solubility of nifedipine (NP) within the core and metoprolol was used not only as the active ingredient but also as osmotic agent. Materials and Methods: NP-cyclodextrin complex was prepared by coprecipitation method. The tablets were prepared and coated with cellulose acetate phthalate-containing dibutyl phthalate as plasticizer at various concentrations. The coated tablets drilled for orifice. The orifice size, level of plasticizer, and coating thickness were used as formulation variables. Finally, the optimized formulation was studied for different pH, agitational speed, and release mechanism. The optimized formulation was also subjected to in vivo prediction for the desired C max and C min using superposition method. Results: Formulation variables such as orifice size, level of plasticizer, and coat thickness of semipermeable membrane were found to affect the drug release from the developed formulations. The optimal elementary osmotic pump was found to deliver both drugs at a rate of approximately zero order for up to 10 h independent of pH and agitational intensity but dependent on the osmotic pressure of the release media. Conclusion: Hence, the prototype design of the system could be applied to other combinations of drugs used for cardiovascular diseases, diabetes, etc.

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Investigation of Factors Influencing Release of Solid Drug Dispersed in Inert Matrices III

Cited by 158 publications

References 3 publications

Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate

Modified solvent evaporation technique for purpose and categorization of Novel Floating Microspheres of Metronidazole: Optimization of pharmacokinetics, in-vitro and stability study using special process capricious like Emulsifier concentration, stirring rate

Optimization and in-vitro Evaluation of Poly (lactic acid) /Mesalazine Microspheres as Drug Carriers

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