Investigation of excitation functions of proton-induced reactions on $^{94,\, 96,\, 98,\, 100}$Mo targets for production of radioisotopes $^{94m,\, 94g,\, 96m,\, 96g,\, 96,\, 99m}$Tc

Artun, Ozan; Aytekin, Hüseyin

doi:10.3906/fiz-1612-2

Cited by 2 publications

(1 citation statement)

References 30 publications

(69 reference statements)

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“…[5][6][7][8] The alternative accelerator-based production methods 9 of both 99 Mo and 99m Tc include 238 U photofission, 10 phototransmutation of 100 Mo via the 100 Mo(,n) 99 Mo channel 11 or the direct production of 99m Tc via the 100 Mo(p,2n) transformation. 12 99m Tc can be produced in small medical cyclotrons, as reveals from the theoretical studies, 13 and the IAEA recommendations. 14 IAEA recommends using medical cyclotrons with proton energy of 18 MeV close the maximum cross section for production of 99m Tc in the 100 Mo(p,2n) 99m Tc reaction on the highly 100 Mo-enriched target material.…”

Section: Introductionmentioning

confidence: 98%

Application of therapeutic linear accelerators for the production of radioisotopes used in nuclear medicine

Konefał

Orlef

Sokół

2022

Polish Journal of Medical Physics and Engineering

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This review paper summarizes the possibilities of the use of therapeutic linear electron accelerators for the production of radioisotopes for nuclear medicine. This work is based on our published results and the thematically similar papers by other authors, directly related to five medical radioisotopes as 99Mo/99mTc, 198Au, 186Re, 188Re, 117mSn, produced using therapeutic linacs. Our unpublished data relating to the issues discussed have also been used here. In the experiments, two types of radiation were included in the analysis of the radioisotope production process, i.e. the therapeutic twenty-megavolt (20 MV) X-rays generated by Varian linacs and neutron radiation contaminating the therapeutic beam. Thus, the debated radioisotopes are produced in the photonuclear reactions and in the neutron ones. Linear therapeutic accelerators do not allow the production of radioisotopes with high specific activities, but the massive targets can be used instead. Thus, the amount of the produced radioisotopes may be increased. Apart from linear accelerators, more and more often, the production of radioisotopes is carried out in small medical cyclotrons. More such cyclotrons are developed, built, and sold commercially than for scientific research. The radioisotopes produced with the use of therapeutic linacs or cyclotrons can be successfully applied in various laboratory tests and in research.

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