Investigation of DNA-damage and Chromosomal Aberrations in Blood Cells under the Influence of New Silver-based Antiviral Complex

Plotnikov, Evgeniy Vladimirovich; Silnikov, Vladimir; Gapeyev, A. B.; Plotnikov, V. M.

doi:10.15171/apb.2016.011

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Milionis et al (2018) evaluated the genotoxicity by the MN test of a new Ag compound (I) obtained by the reaction of AgNO3 with the antibiotic ciprofloxacin by the MN test, in addition to its antibacterial potential. The results showed low genotoxicity in cultures of normal human corneal epithelial cells (HCET) Plotnikov et al (2016). did not detect DNA damage by comet assay and chromosomal aberrations in blood cells of an Ag-based compound of general formula C6H19Ag2N4LiO6S2, even at the highest concentrations.…”

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confidence: 88%

Evaluation of the in vitro cytogenotoxic profile of the silver(I) metal complex with furosemide (Ag-FSE)

Gasparoti

Gomes

Aleixo

et al. 2022

RSD

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The aim of the present study was to evaluate the cytotoxic potential of a new complex of silver(I) with furosemide (Ag-FSE) over a panel of tumor and non-tumor human cells, as well as its genotoxicological safety. According to the results obtained, cell line derived from colorectal adenocarcinoma (Caco-2) was the most sensitive to the Ag-FSE complex, and among the non-tumor cells was the non-transforming fibroblasts known as GM07492A, which stimulated the characterization of cytotoxic properties against these cells. In addition to interfering with the cellular metabolic profile (evidenced by the resazurin method), Ag-FSE alters the integrity of cell membranes (results obtained by the Trypan blue assay) regardless of the cell line evaluated. However, interference with clonogenic capacity is dependent on the cell being tested; the cytotoxic activity evaluated by the clonogenic survival assay was evidenced against Caco-2 cells, but not against GM07492A cells. Furthermore, Ag-FSE did not induce an increase in the extent of DNA damage detectable by the comet assay, nor in the frequency of micronuclei compared to the negative control, demonstrating the absence of genotoxicity under the experimental conditions used. The data of the present study provide information on various biological aspects of the Ag-FSE complex and help in the generation of new drug candidates with potential to impact the health area, targeting cancer treatment.

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confidence: 88%

Evaluation of the in vitro cytogenotoxic profile of the silver(I) metal complex with furosemide (Ag-FSE)

Gasparoti

Gomes

Aleixo

et al. 2022

RSD

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“…It was originally due to their bacterial and antiviral activity [1][2][3]. Nowadays AgNPs have used as a signal enhancer in the spectroscopy, material for creating optical devices, sensors [4].…”

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confidence: 99%

Influence of silver nanoparticles conditions synthesis on their electrochemical properties

Перевезенцева¹,

Gorchakov²,

Petrushin³

et al. 2016

AIP Conference Proceedings

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Influence of stabilizing agent and synthesis temperature on the optical properties of silver nanoparticles as active materials in surface plasmon resonance (SPR) vbimatov@mail.ru Abstract. The shape, size, optical properties and electrochemical activity of silver nanoparticles (AgNPs) obtained by chemical reduction methods depending on the preparation conditions were investigated. Silver sols consist of AgNPs of different shapes. They are as follows spherical -30 nm, polyhedral -35 nm, 50 nm nanorods. It was shown that the position of the absorption spectrum peak in AgNPs depend on the molar ratio of mixture AgNO 3 :Na 3 C 6 H 5 O 7 . The maximum of the absorption spectrum peak of AgNPs is shifted by 10 nm to longer wavelengths area in presence excess of a reducing agent or the increasing of boiling time. After storage for one week the spectrum intensity of AgNPs obtained in the mixture AgNO 3 :Na 3 C 6 H 5 O 7 = 1:1 is increased in comparison with freshly prepared AgNPs, which is caused by the increase of AgNPs quantity of a given size. The AgNPS obtained in the mixture AgNO 3 :Na 3 C 6 H 5 O 7 = 1:3 have the most electrochemical activity. The conditions that the AgNPs have the most electrochemical activity were found.

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“…Different microorganisms can cause a lot of negative consequences both in industrial and home use, and it take a lot of effort to treat consequences of that including health loss, necessity of antibacterial drugs development, etc [1][2][3][4]. Obviously, it is an important task to eliminate bacteria from water.…”

Section: Introductionmentioning

confidence: 99%

Application of Combined Sorbent For Process of Water Purification From Microbial Contamination

et al. 2016

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Investigation of DNA-damage and Chromosomal Aberrations in Blood Cells under the Influence of New Silver-based Antiviral Complex

Cited by 9 publications

References 12 publications

Evaluation of the in vitro cytogenotoxic profile of the silver(I) metal complex with furosemide (Ag-FSE)

Evaluation of the in vitro cytogenotoxic profile of the silver(I) metal complex with furosemide (Ag-FSE)

Influence of silver nanoparticles conditions synthesis on their electrochemical properties

Application of Combined Sorbent For Process of Water Purification From Microbial Contamination

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