Investigation of cortical and subcortical plasticity following short-term unilateral auditory deprivation in normal hearing adults

Maslin, Michael; Munro, Kevin J.; Lim, Vanessa K.; Purdy, Suzanne C.; Hall, Deborah A.

doi:10.1097/wnr.0b013e32835f66ea

Cited by 15 publications

(19 citation statements)

References 21 publications

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“…The changes in ART are consistent with a change in neural gain occurring at the level of the auditory brainstem. This was confirmed by Maslin et al [2013] who investigated cortical and subcortical activity using functional magnetic resonance imaging and the ART, respectively. After 7 days of unilateral earplug use, the authors found a reduction of 3-7 dB in the ART of the plugged ear but no change in cortical activity.…”

Section: Changes In Neural Gain In Humansmentioning

confidence: 72%

“…Studies have explored the physiological and perceptual effects of temporary augmented stimulation or deprivation in normalhearing listeners [Formby et al, 2003;Maslin et al, 2013;Munro and Blount, 2009;Munro and Merrett, 2013;Munro et al, 2007a, b;Munro et al, 2014]. Formby et al [2003] measured the change in loudness perception using the Contour Test of Loudness Perception, in which subjects were asked to rate the loudness of sounds using 7 loudness categories, ranging from very soft to uncomfortably loud [Cox et al, 1997].…”

Section: Changes In Neural Gain In Humansmentioning

confidence: 99%

“…Evidence of changes in neural gain has also been demonstrated using physiological measures following shortterm unilateral earplug or hearing aid use [Maslin et al, 2013;Munro and Blount, 2009;Munro and Merrett, 2013;Munro et al, 2014]. Munro and Blount [2009] and Munro and Merrett [2013] investigated the change in the acoustic reflex threshold (ART).…”

Section: Changes In Neural Gain In Humansmentioning

confidence: 99%

“…This suggests that sound therapy should be personalized and tailored to the hearing loss and/or tinnitus pitch of the individual. However, in the ART studies, significant differences were reported over a wide range of frequencies [Maslin et al, 2013;Munro et al, 2014], and perceptual data have also shown evidence of a frequency-invariant gain mechanism [Formby et al 2003;Munro et al 2014]. This suggests that broadband noise may be sufficient to reduce the neural gain in individuals with hyperacusis.…”

Section: Clinical Relevance Of Abnormal Neural Activitymentioning

confidence: 99%

See 3 more Smart Citations

Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis?

Brotherton

Plack²,

Maslin³

et al. 2015

Audiol Neurotol

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Naturally occurring stimuli can vary over several orders of magnitude and may exceed the dynamic range of sensory neurons. As a result, sensory systems adapt their sensitivity by changing their responsiveness or ‘gain'. While many peripheral adaptation processes are rapid, slow adaptation processes have been observed in response to sensory deprivation or elevated stimulation. This adaptation process alters neural gain in order to adjust the basic operating point of sensory processing. In the auditory system, abnormally high neural gain may result in higher spontaneous and/or stimulus-evoked neural firing rates, and this may have the unintended consequence of presenting as tinnitus and/or sound intolerance, respectively. Therefore, a better understanding of neural gain, in health and disease, may lead to more effective treatments for these aberrant auditory perceptions. This review provides a concise summary of (i) evidence for changes in neural gain in the auditory system of animals, (ii) physiological and perceptual changes in adult human listeners following an acute period of enhanced acoustic stimulation and/or deprivation, (iii) physiological evidence of excessive neural gain in tinnitus and hyperacusis patients, and (iv) the relevance of neural gain in the clinical treatment of tinnitus and hyperacusis.

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Section: Changes In Neural Gain In Humansmentioning

confidence: 72%

Section: Changes In Neural Gain In Humansmentioning

confidence: 99%

Section: Changes In Neural Gain In Humansmentioning

confidence: 99%

Section: Clinical Relevance Of Abnormal Neural Activitymentioning

confidence: 99%

See 2 more Smart Citations

Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis?

Brotherton

Plack²,

Maslin³

et al. 2015

Audiol Neurotol

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View full text Add to dashboard Cite

show abstract

“…Subcortical plasticity, on the other hand, has only been studied in human subjects with unilateral earplug induced auditory deprivation (Decker and Howe 1981;Maslin et al 2013;Munro and Blount 2009).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Brainstem Auditory Evoked Response in Healthy Ears of Unilaterally Deaf Dogs and Bilaterally Hearing Dogs

M¹

2015

J Veterinar Sci Technol

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Aims Auditory plasticity in response to unilateral deafness has been reported in various animal species. Subcortical changes occurring in unilaterally deaf young dogs using the brainstem auditory evoked response have not been evaluated yet. The aim of this study was to assess the brainstem auditory evoked response findings in dogs with unilateral hearing loss, and compare them with recordings obtained from healthy dogs. Methods Brainstem auditory evoked responses (amplitudes and latencies of waves I, II, III, V, the V/I wave amplitude ratio, wave I-V, I-III and III-V interpeak intervals) were studied retrospectively in forty-six privately owned dogs, which were either unilaterally deaf or had bilateral hearing. The data obtained from the hearing ears in unilaterally deaf dogs were compared to values obtained from their healthy littermates. Results Statistically significant differences in the amplitude of wave III and the V/I wave amplitude ratio at 75 dB nHL were found between the group of unilaterally deaf puppies and the control group. The recordings of dogs with single-sided deafness were compared, and the results showed no statistically significant differences in the latencies and amplitudes of the waves between left-(AL) and right-sided (AR) deafness. Conclusions The recordings of the brainstem auditory evoked response in canines with unilateral inborn deafness in this study varied compared to recordings from healthy dogs. Future studies looking into electrophysiological assessment of hearing in conjunction with imaging modalities to determine subcortical auditory plasticity and auditory lateralization in unilaterally deaf dogs are warranted.

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A comparison of the brainstem auditory evoked response in healthy ears of unilaterally deaf dogs and bilaterally hearing dogs

et al. 2016

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AimsAuditory plasticity in response to unilateral deafness has been reported in various animal species. Subcortical changes occurring in unilaterally deaf young dogs using the brainstem auditory evoked response have not been evaluated yet. The aim of this study was to assess the brainstem auditory evoked response findings in dogs with unilateral hearing loss, and compare them with recordings obtained from healthy dogs.MethodsBrainstem auditory evoked responses (amplitudes and latencies of waves I, II, III, V, the V/I wave amplitude ratio, wave I-V, I-III and III-V interpeak intervals) were studied retrospectively in forty-six privately owned dogs, which were either unilaterally deaf or had bilateral hearing. The data obtained from the hearing ears in unilaterally deaf dogs were compared to values obtained from their healthy littermates.ResultsStatistically significant differences in the amplitude of wave III and the V/I wave amplitude ratio at 75 dB nHL were found between the group of unilaterally deaf puppies and the control group. The recordings of dogs with single-sided deafness were compared, and the results showed no statistically significant differences in the latencies and amplitudes of the waves between left- (AL) and right-sided (AR) deafness.ConclusionsThe recordings of the brainstem auditory evoked response in canines with unilateral inborn deafness in this study varied compared to recordings from healthy dogs. Future studies looking into electrophysiological assessment of hearing in conjunction with imaging modalities to determine subcortical auditory plasticity and auditory lateralization in unilaterally deaf dogs are warranted.

show abstract

Investigation of cortical and subcortical plasticity following short-term unilateral auditory deprivation in normal hearing adults

Cited by 15 publications

References 21 publications

Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis?

Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis?

A Comparison of the Brainstem Auditory Evoked Response in Healthy Ears of Unilaterally Deaf Dogs and Bilaterally Hearing Dogs

A comparison of the brainstem auditory evoked response in healthy ears of unilaterally deaf dogs and bilaterally hearing dogs

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