Investigation of chiral inversion and pharmacokinetics of laevo-ornidazole by high-performance liquid chromatography

Mu, Lingli; Zhang, Cheng; Guo, Xin; Luo, Xi; Yu, Ping

doi:10.1111/jcpt.12015

Cited by 10 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, levornidazole is used at a lower dose than tinidazole tablet in clinical settings. The PK parameters after a single oral dose of levornidazole tablets in the present study were comparable to those in a previous report [7]. High-fat diet delays the rate of absorption after Fig.…”

Section: Discussionsupporting

confidence: 91%

“…The PK profiles of levornidazole tablets have been examined after single ascending doses of 250-1000 mg and multiple doses of 500 mg q12h in healthy Chinese subjects. However, the safety and tolerability as well as accumulation of levornidazole have not been evaluated for levornidazole tablets after multiple oral doses [7]. Furthermore, it is required to further clarify the absolute oral bioavailability and the route of elimination of levornidazole tablets.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

Wu¹,

Wang²,

Yü³

et al. 2021

Infect Dis Ther

View full text Add to dashboard Cite

Introduction:Levornidazole is a novel nitroimidazole antimicrobial agent active against anaerobes. We aimed to investigate the pharmacokinetic (PK) profile of levornidazole and PTA [ 99% for B. fragilis (minimum inhibitory concentration B 1.0 mg/l) infections. Conclusion: Levornidazole tablets are absorbed rapidly and completely and distributed extensively with a long half-life and low urinary excretion after a single dose or multiple doses in healthy Chinese subjects. Levornidazole tablets can be taken with or without food. Levornidazole tablets 500 mg q12h and 750 mg q24h are expected to achieve the desired efficacy in B. fragilis infections. Clinical Trail Registration: Trial registration number CTR20160786 at http://www.china drugtrials.org.cn/.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

Wu¹,

Wang²,

Yü³

et al. 2021

Infect Dis Ther

View full text Add to dashboard Cite

show abstract

“…During the research and development of anticancer agent GLB, the pharmacokinetic profile is needed for understanding the absorption, distribution, metabolism and excretion (ADME) of GLB in vivo 22 . The high performance liquid chromatographic - ultraviolet detector (HPLC-UV) is a conventional quantitative analysis method 23 24 25 26 . In according to the ultraviolet absorption wavelength, elution retention time and chromatographic peak area, the content of compound can be accurately measured 27 28 29 30 .…”

mentioning

confidence: 99%

Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS

Wang

Li³

et al. 2015

Sci Rep

View full text Add to dashboard Cite

Fructose-based 3-acetyl-2,3-dihydro-1,3,4-oxadiazole (GLB) is a novel antitumor agent and belongs to glycosylated spiro-heterocyclic oxadiazole scaffold derivative. This research first reported a simple, specific, sensitive and stable high performance liquid chromatography -ultraviolet detector (HPLC-UV) method for the quantitative determination of GLB in plasma. In this method, the chromatographic separation was achieved with a reversed phase C18 column. The calibration curve for GLB was linear at 300 nm. The lower limit of quantification was 10 ng/mL. The precision, accuracy and stability of the method were validated adequately. This method was successfully applied to the pharmacokinetic study in rats for detection of GLB after oral administration. Moreover, the structures of parent compound GLB and its two major metabolites M1 and M2 were identified in plasma using an ultra performance liquid chromatography- electrospray ionization-quadrupole-time of flight- mass spectrometry (UPLC-ESI-QTOF-MS) method. Our results indicated that the di-hydroxylation (M1) and hydroxylation (M2) of GLB are the major metabolites. In conclusion, the present study provided valuable information on an analytical method for the determination of GLB and its metabolites in rats, can be used to support further developing of this antitumor agent.

show abstract

Chiral stationary phase optimized selectivity liquid chromatography: A strategy for the separation of chiral isomers

Hegade

Beer²,

Lynen

2017

Journal of Chromatography A

View full text Add to dashboard Cite

Investigation of chiral inversion and pharmacokinetics of laevo-ornidazole by high-performance liquid chromatography

Cited by 10 publications

References 10 publications

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis

Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS

Chiral stationary phase optimized selectivity liquid chromatography: A strategy for the separation of chiral isomers

Contact Info

Product

Resources

About