Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100

Гайнутдинов, Х. Л.; Андрианов, В. В.; Gainutdinova, T. Kh.; Муранова, Л. Н.; Obynochny, A.A.; Timoshenko, A. Kh.; Штарк, М. Б.; Epstein, O. I.; Yurtaeva, S. V.; Jafarova, G. G.

doi:10.1007/s10517-009-0367-8

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…The EPR signals of cytochrome P-450 (g y = 1.92, g x = 2.25, g z = 2.42). iron-sulfur (FeS) containing centers of adrenodoxin (g ‖ = 1.94, g ┴ = 2.02), nitrosyl complexes of heme (HbNO) (g c = 2.01), and nonheme iron (FeSNO) (g = 2.03) were identified by their g-factors (Simpson & Miller, 1978;Pulatova et al, 1989;Tuckey et al, 2001) (calculated according to the signal's position relative to the spectral lines of the standard sample (Mn 2 in MgO powder)) (Kirima et al, 2003;Gainutdinov et al, 2009).…”

Section: Experimental Studiesmentioning

confidence: 99%

Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)

Sanikidze

Cheishvili

Shekiladze

et al. 2019

Current Topics in Biophysics

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The aim of the study was to establish the role of nitric oxide (NO) in the regulation of steroidogenesis in the placenta during physiological pregnancy and experimental preeclampsia (PE) in rats. EPR centers of the placenta, free NO and its metabolites were determined by the Electron Paramagnetic Resonance (EPR) method. At the last stage of pregnancy in the EPR spectra of the rats’ placenta with PE alterations of the signals intensity of mitochondrial steroidogenic electron transport proteins were detected: the FeS-centers of adrenodoxin decreased, the ferricytochrome P-450 increased, the free NO content decreased, and the complexes of NO with heme (HbNO) and non-heme iron (FeSNO) were detected. These data indicate the violation of placental steroidogenesis, which is confirmed by a decrease in the level of progesterone in blood. Therefore, the nitrosylation of mitochondrial proteins is an important redox-dependent mechanism of regulation of the intensity of steroidogenesis.

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Section: Experimental Studiesmentioning

confidence: 99%

Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)

Sanikidze

Cheishvili

Shekiladze

et al. 2019

Current Topics in Biophysics

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“…Concentration of NO in both heart and ganglia fluctuates around 1 nM, which is decreased by NO synthase (NOS) inhibitor Nω-nitro-L-arginine methyl ester (Mantione and Stefano, 2004). In the heart and CNS of Helix the NO release was also suppressed by a paradigm that mimics depression and fear (Gainutdinov et al, 2008). The endogenous sources of NO in Aplysia are L29 interneurons of left abdominal ganglion, since an in situ hybridization revealed expression of NOS (Antonov et al, 2007).…”

Section: Molluscan Heartsmentioning

confidence: 99%

The neuronal control of cardiac functions in Molluscs

Kodirov

2011

Comparative Biochemistry and Physiology Part A: Molecular &

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In this manuscript, I review the current and relevant classical studies on properties of the Mollusca heart and their central nervous system including ganglia, neurons, and nerves involved in cardiomodulation. Similar to mammalian brain hemispheres, these invertebrates possess symmetrical pairs of ganglia albeit visceral (only one) ganglion and the parietal ganglia (the right ganglion is bigger than the left one). Furthermore, there are two major regulatory drives into the compartments (pericard, auricle, and ventricle) and cardiomyocytes of the heart. These are the excitatory and inhibitory signals that originate from a few designated neurons and their putative neurotransmitters. Many of these neurons are well-identified, their specific locations within the corresponding ganglion are mapped, and some are termed as either heart excitatory (HE) or inhibitory (HI) cells. The remaining neurons are classified as cardio-regulatory, and their direct and indirect actions on the heart’s function have been documented. The cardiovascular anatomy of frequently used experimental animals, Achatina, Aplysia, Helix, and Lymnaea is relatively simple. However, as in humans, it possesses all major components including even trabeculae and atrio-ventricular valves. Since the myocardial cells are enzymatically dispersible, multiple voltage dependent cationic currents in isolated cardiomyocytes are described. The latter include at least the A-type K+, delayed rectifier K+, TTX-sensitive Na+, and L-type Ca2+ channels.

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Диваза В Терапии Цереброваскулярной Болезни: Механизм Действия И Показания К Назначению Препарата

Воробьева,

Фатеева

2015

Psychiatry

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Диваза, комбинированный препарат c оригинальным механизмом действия, оказывает модифицирующее воздействие на функциональную активность белка S-100 и эндотелиальную NO-синтазу, показан для лечения пациентов с хронической цереброваскулярной болезнью. Приведен обзор экспериментальных и клинических исследований механизмов действия и терапевтической эффективности комбинированного препарата Диваза на различных экспериментальных моделях ишемии головного мозга и нейродегенеративных заболеваний и в клинической практике.

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Investigation of Changes in NO Content during Long-Term Sensitization in Edible Snail Using EPR-Spectroscopy: Effects of Antibodies to Calcium-Binding Protein S-100

Cited by 3 publications

References 8 publications

Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)

Role of the Nitric Oxide (NO) in the Regulation of Steroidogenesis in Placenta During Physiological Pregnancy and Preeclampsia (Experimental Study)

The neuronal control of cardiac functions in Molluscs

Диваза В Терапии Цереброваскулярной Болезни: Механизм Действия И Показания К Назначению Препарата

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