Investigation of Biological Activities of Enzymatic Hydrolysate of Spirulina

손민희,; 박근형,; 최아름,; 유귀재,; In, Man-Jin; 김동호,; 채희정,

doi:10.3746/jkfn.2009.38.2.136

Cited by 10 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spirulina is already being used as a harmless pharmacological additive and the clinical trials have showed that substances present in Spirulina have diverse curative and healing effects. As a result, these findings have led many groups to actively study Spirulina for its applicability in the greater context of medicine …”

Section: Introductionmentioning

confidence: 99%

Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract

et al. 2014

View full text Add to dashboard Cite

Silk fibroin (SF) nanofiber scaffold containing microalgae Spirulina extract were prepared by electrospinning and the performance and functionality of the scaffold were evaluated. The viscosity and conductivity of the dope solution of Spirulina containing SF were examined for electrospinability and we found that the morphological structure of SF nanofiber is affected by the concentration of Spirulina extract added. The platelet adhesion and coagulation time test confirmed that the Spirulina containing SF nanofiber scaffold had excellent ability to prevent blood clotting or antithrombogenicity that is comparable to heparin. Low cytotoxicity and excellent cell adhesion and proliferation were also observed for Sprulina containing SF nanofiber scaffold by methylthiazolyldiphenyl-tetrazolium bromide assay and confocal fluorescence microscope using fibroblast and human umbilical vein endothelial cells. Based on these results, we believe SF nanofiber scaffold containing Spirulina extract has the potential to be used as tissue engineering scaffold that requires high hemocompatibility.

show abstract

Section: Introductionmentioning

confidence: 99%

Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Spirulina has been consumed by humans for thousands of years without side effects and has been selected as space food by the US National Aeronautics and Space Administration (NASA). Since Spirulina has diverse active substances, such as C-phycocyanin, beta-carotene, chlorophyll, and functional fatty acids, it has been reported to have excellent anti-cancer, immunity enhancing, skin improving, and anti-inflammatory effects and to be useful in treating hypertension, diabetes, and diseases related to metabolism, such as liver dysfunctions [27][28][29]. In particular, Spirulina contains at least 50-100% more beta-carotene and chlorophyll, which are highly antioxidative, than other natural products [27,30].…”

Section: Introductionmentioning

confidence: 99%

Increased Anti-Inflammatory Effects on LPS-Induced Microglia Cells by Spirulina maxima Extract from Ultrasonic Process

et al. 2019

View full text Add to dashboard Cite

The Spirulina maxima exact from a non-thermal ultrasonic process (UE) contains 17.5 mg/g of total chlorophyll, compared to 6.24 mg/g of chlorophyll derived from the conventional 70% ethanol extraction at 80 °C for 12 h (EE). The UE also showed relatively low cytotoxicity against murine microglial cells (BV-2) and inhibited the production of the inflammatory mediators, NO and PGE2. The UE also effectively suppresses both mRNA expression and the production of pro-inflammatory cytokines, such as TNF-α, IL-6 and IL-1β, in a concentration-dependent manner. Notably, TNF-α gene and protein production were most strongly down-regulated, while IL-6 was the least affected by all ranges of treatment concentrations. This work first demonstrated a quantitative correlation between mRNA expression and the production of cytokines, showing that suppression of TNF-α gene expression was most significantly correlated with its secretion. These results clearly proved that the anti-inflammatory effects of Spirulina extract from a nonthermal ultrasonic process, which yielded high concentrations of intact forms of chlorophylls, were increased two-fold compared to those of conventional extracts processed at high temperature.

show abstract

The Application of 4-Hexylresorcinol in Tissue Engineering

Kim

2024

Biomedical Application of 4-Hexylresorcinol

View full text Add to dashboard Cite

Investigation of Biological Activities of Enzymatic Hydrolysate of Spirulina

Cited by 10 publications

References 14 publications

Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract

Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract

Increased Anti-Inflammatory Effects on LPS-Induced Microglia Cells by Spirulina maxima Extract from Ultrasonic Process

The Application of 4-Hexylresorcinol in Tissue Engineering

Contact Info

Product

Resources

About