Investigation of Aryl Hydrocarbon Receptor, Zinc, and Vitamin B12 Levels in Chronic Gastritis with Helicobacter pylori Infection

Soyocak, Ahu; Ergün, Dilek Düzgün; Koç, Gülşah; Ergün, Sefa; Özsobacı, Nural Pastacı

doi:10.1007/s12011-021-02667-5

Cited by 10 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phull et al ( 31 ), Zhang et al ( 32 ) and Toyonaga et al ( 33 ) found that H. pylori infection was not associated with serum vitamin A and E levels. The vitamin B 12 results from Trimarchi et al ( 37 ), Sarari et al ( 11 ) and Ulasoglu et al ( 42 ) indicated that H. pylori had an adverse effect on serum vitamin B 12 levels, whereas other observational studies ( 35 , 36 , 40 , 44 ) presented a null association between H. pylori and vitamin B 12 . The findings of Tamura et al ( 34 ), Shuval-Sudai et al ( 36 ) and Ulasoglu et al ( 42 ) showed that H. pylori -negative patients had higher serum folate levels than H. pylori -positive patients; however, some studies ( 35 , 39 , 41 , 43 , 44 ) did not present similar results.…”

Section: Discussionmentioning

confidence: 98%

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai

Jin

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

BackgroundOver recent decades, epidemiological studies have shown relationships between vitamins and Helicobacter pylori (H. pylori) infection and eradication, but the results are controversial.MethodsA comprehensive meta-analysis and systematic review were conducted to clarify the relationships between common types of vitamins and H. pylori. We applied meta-regression, subgroup analysis and sensitivity analysis to obtain available evidence. Articles published from January 1991 to June 2021 in PubMed, EMBASE, and the Cochrane Library were searched.ResultsIn total, we identified 48 studies. The results indicate that H. pylori -positive patients had lower serum vitamin B12 [standardized mean difference (SMD) = −0.30; 95% confidence interval (CI): −0.53 – −0.08], folate (SMD = −0.69; 95% CI: −1.34 – −0.04), vitamin C (SMD = −0.37; 95%CI: −0.57 – −0.18) and vitamin D (SMD = −0.34; 95% CI: −0.49 – −0.18) levels than H. pylori-negative patients. Patients in which H. pylori had been successfully eradicated had higher serum vitamin D levels (SMD = 1.37; 95% CI: 0.37–2.38) than in patients in which eradication had been unsuccessful. The serum vitamin B12 levels of H. pylori-positive patients improved after successful H. pylori eradication therapy (SMD = 1.85; 95% CI: 0.81–2.90), and antioxidant vitamin supplementation to an H. pylori eradication regimen improved the eradication rate (risk ratio = 1.22; 95% CI: 1.02–1.44 for per-protocol analysis; risk ratio = 1.25; 95% CI: 1.06–1.47 for intention-to-treat analysis).ConclusionsH. pylori infections decrease the serum levels of several types of vitamins, eradication of H. pylori could rescue its adverse effects, and antioxidant vitamin supplementation may improve the H. pylori eradication rate.Systematic Review Registrationidentifier: CRD42021268127.

show abstract

Section: Discussionmentioning

confidence: 98%

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Cai

Jin

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…While body function decreases with age and gastrointestinal function in CG patients reduces physiological function and everyday activities, thus affecting their quality of life, retired and elderly individuals had lower PCS scores. This is because, at the same time that body function declines with age, both factors contribute to the body's tendency to become less functional (22). Higher MCS scores have been found among individuals with a history of smoking and drinking, and we hypothesized that these behaviors would in some situations be beneficial for emotional release.…”

Section: Discussionmentioning

confidence: 98%

Mediating effect of gastrointestinal symptoms on dietary behavior and quality of life in Chinese adults with chronic gastritis—a cross-sectional study

et al. 2023

View full text Add to dashboard Cite

BackgroundChronic gastritis is accompanied by varying degrees of gastrointestinal symptoms, which affect people’s quality of life. The association between dietary behaviors and gastrointestinal symptoms of patients with chronic gastritis has been proved recently. However, no studies have been conducted to investigate the relationship between dietary behaviors, gastrointestinal symptoms, and quality of life.MethodsA cross-sectional survey of 176 patients diagnosed with chronic gastritis aged 18 to 65 years, comprising their information on demographic characteristics, dietary behaviors, gastrointestinal symptoms, and quality of life, was collected. A descriptive analysis and a correlation matrix were used to illuminate the characteristics of the subjects and bivariate correlation, respectively. The mediation model was analyzed using the PROCESS macros for SPSS.ResultsDemographic characteristics were found to influence the symptoms, dietary behaviors, and quality of life of chronic gastritis patients; in particular, students categorized by occupation had higher levels of gastrointestinal symptoms and lower levels of quality of life and dietary behavior. The study variables were all pound related. We found that gastrointestinal symptoms played a partial mediating role between dietary behavior and both the physical components summary and mental components summary, and the ratios of mediating effects to the total effect on the physical components summary and mental components summary were 23.5% and 21.5%, respectively.ConclusionOur survey discovered that dietary behavior, gastrointestinal symptoms, and quality of life were all pairwise related. The effect of dietary behavior on quality of life was partially mediated by gastrointestinal symptoms. These results may provide a novel perspective for medical staff in improving the quality of life of patients with chronic gastritis.

show abstract

“…[91] It is considered to be a main etiological element that leads to severe gastritis. [92] The intrusion of the sub-epithelial lamina propria by phagocytes, particularly neutrophils and macrophages, which produce a large amount of ROS as part of the host defense response, is one distinctive hallmark of gastritis. [7,93] The amount of oxygen produced by the xanthine oxidase-stimulated NADPH oxidase in gastric cells is increased by H. pylori infection.…”

Section: Chemistryselectmentioning

confidence: 99%

“…A crucial component of the pathogenesis of H. pylori infection is its persistence in the inflamed gastric mucosa, leading to peptic ulceration and gastric cancer [91] . It is considered to be a main etiological element that leads to severe gastritis [92] . The intrusion of the sub‐epithelial lamina propria by phagocytes, particularly neutrophils and macrophages, which produce a large amount of ROS as part of the host defense response, is one distinctive hallmark of gastritis [7,93] .…”

Section: Gastro‐protective Activities Of a Marmaelosmentioning

confidence: 99%

Evaluating the Anti‐Gastric Ulcer Activity of Aegle marmelos: A Brief Review

et al. 2023

View full text Add to dashboard Cite

Gastric ulcer is a deep hole in the stomach wall that penetrates the entire mucosa. About 10 % of the world population suffers from gastrointestinal tract disorders frequently known as gastric ulcers. Synthetic drugs are used to prevent gastric ulcers by suppressing the formation of gastric acid or stopping bacterial infections, however, these synthetic drugs have a number of harmful effects. Therefore, drug candidates with improved potency and minimal toxicity are crucial for the treatment and management of gastric ulcers. Recently, there has been a lot of interest in the medicinal potential of plants and their ability to treat gastric ulcers. There is an urgent need for herbal remedies to treat ulcers, and Aegle marmelos presents a better option due to scientifically proven antibacterial and antiulcer properties. In this context, A. marmelos highlights various benefits including anti-inflammatory and antioxidant properties. It is well known that every component of A. marmelos has therapeutic and medical use. The two main causes of stomach ulcers are Helicobacter pylori and NSAIDs. A. marmelos shows strong antioxidant and antiulcer effects and guard against H. pylori-caused ulcers on the stomach mucosa by inhibiting secretory factors and activating antioxidant processes.

show abstract

Investigation of Aryl Hydrocarbon Receptor, Zinc, and Vitamin B12 Levels in Chronic Gastritis with Helicobacter pylori Infection

Cited by 10 publications

References 26 publications

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Vitamins and Helicobacter pylori: An Updated Comprehensive Meta-Analysis and Systematic Review

Mediating effect of gastrointestinal symptoms on dietary behavior and quality of life in Chinese adults with chronic gastritis—a cross-sectional study

Evaluating the Anti‐Gastric Ulcer Activity of Aegle marmelos: A Brief Review

Contact Info

Product

Resources

About