Investigation of Antidiabetic, Antihyperlipidemic, and <i>In Vivo</i> Antioxidant Properties of <i>Sphaeranthus indicus</i> Linn. in Type 1 Diabetic Rats: An Identification of Possible Biomarkers

Ramachandran, Subramaniam; Asokkumar, Kuppusamy; Maheswari, M.; Ravi, T. K.; Sivashanmugam, A.T.; Saravanan, S.; Rajasekaran, A.; Dharman, J.

doi:10.1155/2011/571721

Cited by 43 publications

(38 citation statements)

References 39 publications

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“…Our results revealed that liver and kidney MDA levels significantly increased in rats with experimental diabetes in comparison with the non-diabetic control group. In agreement with our study, Kakkar et al (1997), , Punitha et al (2006), Selvan et al (2008), Chakraborty and Das (2010), Kamel et al (2011), andRamachandran et al (2011) reported that STZ administration increased hepatic and renal MDA levels. The rise in hepatic MDA levels may be due to the high concentration of FFAs in diabetic animals compared with the non-diabetic control group as a consequence of the decrease in plasma insulin levels.…”

Section: Discussionsupporting

confidence: 92%

Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats

Habib

Serra-Barcellona

Honoré

et al. 2015

Pharmaceutical Biology

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Context: Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson, Asteraceae (yacon) roots are a natural product recognized by the traditional medicine to treat diabetes-related problems. There are no reports concerning the potential of yacon roots to reduce oxidative stress and ameliorate diabetes complications in diabetic animals. Objective: This work analyzes the in vivo antioxidant activity and beneficial effects of yacon roots, using a model of streptozotocin-induced diabetes in rats. Materials and methods: Lipid peroxidation and other indicators of oxidative stress were determined in liver and kidney homogenates from non-diabetic rats, untreated diabetic rats, and diabetic rats treated orally with yacon flour (340 mg fructooligosaccharide/kg/d) as a diet supplement for 90 d. Biochemical parameters were determined in liver, kidney, and blood at the end of the experimental period. Results: Yacon supplementation to diabetic rats produced a significant decrease in malondialdehyde levels in both liver (À30.97%) and kidney (À19.15%). Hepatic superoxide dismutase and catalase activities were significantly lower in diabetic-treated rats (À13.46 and À64.33%, respectively) compared with diabetic controls. Similar results were observed in kidney. The treatment of diabetic rats produced an increase of glutathione peroxidase and glutathione levels in liver (172.50 and 35.91%, respectively) and kidney (177.78 and 57.76%, respectively). Plasma cholesterol and triacylglycerol levels and liver fatty acid composition, which were altered in diabetic rats, reverted back to nearly normal with yacon treatment. Conclusions: These results indicate that yacon root flour is a potential diet supplement with high in vivo antioxidant activity.

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Section: Discussionsupporting

confidence: 92%

Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats

Habib

Serra-Barcellona

Honoré

et al. 2015

Pharmaceutical Biology

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“…STZ was dissolved in freshly prepared 0.1 M cold citrate buffer (pH 4.5) and administered by intraperitoneal route (60 mg/kg) to the overnight fasted rats [9] . After 6 h of STZ injection, rats were received 5% dextrose solution for the next 24 h to prevent STZ induced fatal hypoglycemia as a result of massive pancreatic insulin release after its administration [10] .…”

Section: Induction Of Experimental Diabetes In Ratsmentioning

confidence: 99%

“…Diabetes was confirmed 72 h after induction by measurement of tail vein blood glucose levels using glucose meter (Glucocard™ 01-mini, Arkray Factory, Inc., Japan) by glucose oxidase-peroxidase method using strips. Diabetic rats were kept 14 days under standard laboratory condition for the stabilization of blood glucose levels [9] . After 14 days induction of diabetes, blood glucose was again determined and animals with a blood glucose level greater than 250 mg/dL were selected for the study.…”

Section: Induction Of Experimental Diabetes In Ratsmentioning

confidence: 99%

Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats

Ramachandran¹,

Rajasekaran²,

Manisenthilkumar³

2012

Asian Pacific Journal of Tropical Biomedicine

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“…This possible mechanism was observed in several studies, which reported the hypoglycemic activity of plant extracts that have high content of polyphenolic compounds, such as: Cinnamomum parthenoxylon (Jia et al, 2009), Lactuca indicates (Hou et al, 2007), Dimocarpus longan (Li et al, 2015), Bauhinia monandra (Alade et al, 2012) and Sphaeranthus indicus (Ramachandran et al, 2011).…”

Section: Resultsmentioning

confidence: 81%

Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

Carvalho¹,

Lacerda²,

Ferreira³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Calophyllum brasiliense (Cb) belongs to the Clusiaceae family and it is generally used for diabetes treatment. The aim of this study was to evaluate the anti-diabetic effect of Cb's hydroethanolic extract (CBE) on diabetic induced rats by streptozotocin and evaluate the content of polyphenols and tannins of the extract. The polyphenols and tannins evaluation in the extract were determinated by a spectrophotometer in 760 nm and isocratic HPLC system and reverse phase column (C18). The induction of diabetes was performed by intraperitoneal injection of streptozotocin (55 mg/kg) and was confirmed by a histopathological analysis. The total content of polyphenols and tannins (gallic acid) in CBE was 0.025 ± 0.0028 mg/mL (4.77%) and 8.262 ± 0.417 µg/mL, respectively. According to the oral glucose tolerance test that was performed both in normal and diabetic mice, the treatment with 500 mg/kg of CBE appeared to significantly reduce the blood glucose levels compared to the untreated group (P < 0.001). The treatment of diabetic mice with 500 mg/kg of CBE for 30 days significantly improved diabetes clinical symptoms (polydipsia, polyuria, polyphagia and weight loss) (P < 0.001). After the urinary glucose analysis, it was found that the treatment with 500 mg/kg of CBE significantly decreased the urinary glucose levels at an average of 177.55 ± 17.8 mg/dL (32.40%) (P < 0.001). In relation to the blood glucosemeasurements, it was shown that the groups treated with 500 mg/kg CBE and 3 mg/kg of Glibenclamide had significantly lower levels of blood glucose when compared to nontreated group (P < 0.001) 24.09% (143.36 ± 19.6 mg/dL) and 36.04% (200.08 ± 14.9 mg/dL), respectively). The histopathological analysis revealed an increase in the number of endocrine cells in the islets of Langerhans in the groups treated with CBE500 and insulin. Therefore, it was concluded that the treatment with 500 mg/kg of CBE exhibited anti-diabetic activity.

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Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats: An Identification of Possible Biomarkers

Cited by 43 publications

References 39 publications

Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats

Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats

Investigation of hypoglycemic, hypolipidemic and antioxidant activities of aqueous extract of Terminalia paniculata bark in diabetic rats

Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

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