Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (&lt;i&gt;Oreochromis niloticus&lt;/i&gt;)

Sassa-deepaeng, Tanongsak; Chaisri, Wasana; Pikulkaew, Surachai; Okonogi, Siriporn

doi:10.5582/ddt.2017.01006

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…The single bond between C2 and C3 in naringenin, by reducing the electronegativity of the 4-keto group, prohibited the interplay of this group with the prosthetic group [20,23]. Quercitin, quercetin, and chrysin aromatase inhibitory potency increased, respectively [15,41]. The core structure of the three compounds was the same but quercetin had two hydroxyl groups at the C3 0 and C4 0 positions [42], and adding the glycoside formed from deoxyrhamnose substitution at C3 to quercetin yielded quercitrin [38].…”

Section: Discussionmentioning

confidence: 99%

“…The core structure of the three compounds was the same but quercetin had two hydroxyl groups at the C3 0 and C4 0 positions [42], and adding the glycoside formed from deoxyrhamnose substitution at C3 to quercetin yielded quercitrin [38]. Therefore, the structure of the compounds was related to the activity of aromatase with regard to the hydrophobic of the active site of aromatase, the substitution of the OH group or sugar led to decreased hydrophobicity of chrysin and lowered its potential anti-aromatase activity [41]. The 4 0 , 5, 7-trihydroxy-8-prenylnaringenin (8-PN) is a prenylflavonoid where the prenyl group is located on C8 and its potential anti-aromatase is higher than that of chrysin [31,43].…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review

Balam

Ahmadi

Ghorbani

2020

Heliyon

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The cytochrome P450 enzyme functions as the rate-limiting enzyme in changing androgens to estrogens. Inhibition of aromatase is one of the significant objectives of treatment of hormone-dependent diseases such as breast cancer, especially in post-menopausal women. Natural compounds like chrysin, as a flavor that has a high concentration in honey and propolis, are rich sources of them can be useful in inhibiting aromatase for chemoprevention following treatment or in women at risk of acquiring breast cancer. This study intended to summarize the existing evidence on the effect of chrysin on aromatase activity. We systematically searched Science Direct, PubMed and Google Scholar and hand searched the reference lists of identified relevant articles, up to 5 February, 2019. Articles with English abstracts that reported the effect of chrysin on aromatase inhibition and without publication date restriction were investigated. Twenty relevant articles were chosen from a total of 1721 articles. Only one study was performed on humans and two studies were assayed on rats, while other studies were evaluated in vitro. All the studies except one showed that chrysin had the potency of aromatase inhibition; however, only one study performed on endometrial stromal cells showed that chrysin and naringenin did not indicate aromatase inhibitory properties. Various assay methods and experimental conditions were the important aspects leading to different results between the studies. Chrysin has potency in inhibition of the aromatase enzyme and thus can be useful in preventing and treating the hormone-dependent breast cancer and as an adjuvant therapy for estrogen-dependent diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review

Balam

Ahmadi

Ghorbani

2020

Heliyon

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PEGylation of Chrysin Improves Its Water Solubility while Preserving the In Vitro Biological Activity

Oggero,

Gasser,

Zacarías

et al. 2023

J. Agric. Food Chem.

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Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Talebi

Farkhondeh

et al. 2021

Cancer Cell Int

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Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract

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Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (<i>Oreochromis niloticus</i>)

Cited by 3 publications

References 40 publications

Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review

Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review

PEGylation of Chrysin Improves Its Water Solubility while Preserving the In Vitro Biological Activity

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

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