This paper reports, for the first time, on waveguide-based resonators implemented in scandium-doped aluminum nitride-onsilicon (ScAlN-on-Si) stack to simultaneously benefit from large piezoelectric constants of ScAlN and low acoustic dissipation in single crystal silicon. 1m-thick ScAlN film with Sc content of 7% is reactively sputtered on silicon substrates using ac-powered dualtarget S-gun magnetron with Al targets containing embedded pure Sc pellets. A Cl2/H2 based low-power plasma etching recipe is developed to pattern resonators with smooth vertical sidewalls. Inand out-of-plane waveguide-based resonator prototypes with large electromechanical coupling coefficient (kt 2 ) and high quality-factor (Q) are implemented over 80 MHz -3.5 GHz demonstrating kt 2 of 0.7%-2.9% and Q of 2000-6400. Specifically, a high 0 × of 4.3 × 10 12 is measured for a resonator at 3.5 GHz, and a high 2 × of 51 is measured at 108 MHz. The large 2 × of ScAlNon-Si waveguide-based resonators along with lithographical frequency tailorability demonstrate their potential for realization of highly integrated front-end filters for multi-band 5G systems.