Investigating the role of the growth hormone–insulin-like growth factor (GH–IGF) axis as a determinant of male bone mineral density (BMD)

Patel, Mayank; Arden, N K; Masterson, Liam; Phillips, David I. W.; Swaminathan, R.; Syddall, H E; Byrne, Christopher D.; Wood, P J; Cooper, Cyrus; Holt, Richard

doi:10.1016/j.bone.2005.06.016

Cited by 35 publications

(21 citation statements)

References 30 publications

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“…There also occurred suppression of the synthesis of IGF-1, which is an important regulator of growth and development in normal bone. Most studies have demonstrated that serum IGF-1 levels correlate positively with BMD in men [24][25][26] , and decreasing IGF-1 has been postulated as a primary contributing factor in male age-related bone loss [27,28] . In our experiment, decreased serum IGF-1 in orchidectomized rat was indicative of slowed bone formation.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

et al. 2012

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Aim: Our study aimed to investigate the effect of amlodipine on bone metabolism in orchidectomized rats. Methods: Eight-week-old rats were divided into three groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD). The experimental group after orchidectomy (ORX+AML) received SLD enriched with amlodipine for 12 weeks. Bone marker concentrations in serum of PINP, OPG and IGF-1, and the levels of CTX-I, BAP and BMP-2 in a bone homogenate were measured using enzyme-linked immunosorbent assay. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. The femurs were used for biomechanical testing. Results: Bone markers (CTX-I, BAP, BMP-2) in ORX were higher versus SHAM. In ORX+AML there was a decrease in PINP, CTX-I, BAP, BMP-2 and OPG versus ORX. IGF-1 was decreased in ORX versus SHAM. In ORX+AML it was increased versus ORX. In ORX, a decrease was demonstrated versus SHAM in BMD of the whole body, in the lumbar vertebrae and in both femurs. In ORX+AML there was an increase in BMD of the whole body versus ORX. Three-point bending test revealed a decrease in maximal load values in ORX versus SHAM. After amlodipine administration there was an increase in the left femur versus ORX. Conclusions: Amlodipine is capable of mitigating the negative effects of orchidectomy and could be a good prevention of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

et al. 2012

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“…Whatever its mechanism, the milk-dependent increase in IGF-1 levels has been suggested to have positive and negative impacts on health, even though the latter effects are still controversial [40][41][42][43][44]. IGF-1 has been proposed to be a link between milk intakes and growth in prepubertal children [36,45].…”

Section: Discussionmentioning

confidence: 99%

Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents

et al. 2008

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“…Recent work suggests that this impairment reflects osteoblast dysfunction (39). Potential etiologies of idiopathic osteoporosis include altered estrogen status, low IGF-1 concentration and LRP5 gene mutations (40)(41)(42). As of this writing, none of these potential etiologies is amenable to specific corrective therapy.…”

Section: Pathophysiologymentioning

confidence: 91%

Osteoporosis in men

Binkley¹

2006

Arq Bras Endocrinol Metab

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Osteoporosis is defined as "a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture". Approximately 40-50% of women sustain osteoporotic fractures in their lifetime; as such, it is appropriate that studies initially focused upon females. Despite an increased recognition of osteoporotic fractures in men, there continues to be neglect of this disease in males. This ongoing neglect is inappropriate as 25-33% of men in some populations will sustain osteoporotic fractures in their lifetime. Testosterone plays an important role in male skeletal health. However, recent data suggest that estrogen may in fact be the dominant hormone regulating skeletal status in both men and women. BMD measurement may be utilized for osteoporosis diagnosis and to assist with fracture risk prediction in men prior to their sustaining a fracture. Recognizing this need, the International Society for Clinical Densitometry (ISCD) recommended and recently reaffirmed use of a BMD T-score of -2.5 or below be utilized to diagnose osteoporosis in men. Androgen therapy of hypogonadal men may be considered with the caveat that data do not exist to document that this treatment reduces fracture risk. At this time, the data is inadequate to support use of androgen treatment in eugonadal men with osteoporosis. Parathyroid hormone treatment does increase BMD; existing studies have not been of adequate size or duration to document fracture reduction efficacy. Bisphosphonate therapy increases BMD, reduces vertebral fracture risk and is considered the standard of care for osteoporotic men at this point in time. RESUMO Osteoporose em Homens.A osteoporose é definida como "uma doença esquelética sistêmica caracterizada por baixa massa óssea e deterioração da microarquitetura do tecido ósseo com conseqüente aumento da susceptibilidade a fraturas". Aproximadamente 40-50% das mulheres apresentarão uma fratura osteoporótica durante suas vidas, e por isso os estudos iniciais focalizaram o sexo feminino. A despeito do reconhecimento cada vez mais freqüente da ocorrência de fraturas osteoporóticas em homens, a doença continua sendo negligenciada no sexo masculino. Isto não é apropriado na medida em que 25-33% dos homens em algumas populações apresentarão fraturas osteoporóticas durante suas vidas. A testosterona exerce um importante papel na integridade esquelética masculina, contudo dados recentes sugerem que os estrógenos são de fato os hormônios dominantes na regulação esquelética em ambos os sexos. A medida da densidade mineral óssea pode ser utilizada no diagnóstico e para avaliar o risco de fraturas, e a ISCD recomenda que o escore T de -2.5 ou menos seja usado como critério diagnóstico no homem. A terapia androgênica no hipogonadismo masculino deve ser original articleOsteoporosis in Men

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Investigating the role of the growth hormone–insulin-like growth factor (GH–IGF) axis as a determinant of male bone mineral density (BMD)

Cited by 35 publications

References 30 publications

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy

Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents

Osteoporosis in men

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