Investigating the Role of Shape and Size of Gold Nanoparticles on Their Toxicities to Fungi

Liu, Kangze; He, Zhonglei; Byrne, Hugh J.; Curtin, James F.; Tian, Furong

doi:10.20944/preprints201802.0002.v1

2018

DOI: 10.20944/preprints201802.0002.v1

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Investigating the Role of Shape and Size of Gold Nanoparticles on Their Toxicities to Fungi

Kangze Liu¹,

Zhonglei He²,

Hugh J. Byrne³

et al.

Abstract: Abstract:The possibility of releasing gold nanoparticles (GNP) into the environment has been 9 rapidly increasing with the wide spread and flourishing application of gold nanoparticles (GNPs) 10 in a wide range of areas. Consequently, environmental effects of GNP, especially toxicities to 22results also showed that different species of fungus reacts differently to same GNPs, and 23Penicillium chrysogenum was relatively more sensitive under the exposure to GNPs. 24

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Cited by 5 publications

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Limits of Detection of Mycotoxins by Laminar Flow Strips: A Review

et al. 2022

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Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using different nanomaterials, nanoparticle size, and replicates was reviewed in an attempt to identify the most important determinants of the limit of detection (LOD). It is found that the particle size and type of materials contribute significantly to determining the LOD. The nanoparticle sizes used in most studies have been in the range 15–45 nm and gold nanoparticle-based ICSTs have been shown to exhibit the lowest LOD. Perspectives for potential future development to reduce the LODs of ICSTs are also discussed.

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Limits of Detection of Mycotoxins by Laminar Flow Strips: A Review

et al. 2022

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Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

et al. 2022

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Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and disposal, it may lead to the unmanaged release of toxic nanomaterials. Here we attempt to foster connections between the domains of biosensors development and human and environmental toxicology to encourage a holistic approach to the development and scale-up of biosensors. We begin by exploring the toxicity of nanomaterials commonly used in biosensor design. From our analysis, we introduce five factors with a role in nanotoxicity that should be considered at the biosensor development stages to better manage toxicity. Finally, we contextualize the discussion by presenting the relevant stages and routes of exposure in the biosensor life cycle. Our review found little consensus on how the factors presented govern nanomaterial toxicity, especially in composite and alloyed nanomaterials. To bridge the current gap in understanding and mitigate the risks of uncontrolled nanomaterial release, we advocate for greater collaboration through a precautionary One Health approach to future development and a movement towards a circular approach to biosensor use and disposal.

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Effects of PEG-Coated Silver and Gold Nanoparticles on Spirulina platensis Biomass during Its Growth in a Closed System

et al. 2020

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Silver and gold nanoparticles are promising tools for medical and industrial applications; therefore, their ecotoxicity should be carefully examined. There are many publications that discuss their effects at high concentrations on various organisms, while the effects of low doses have not been sufficiently investigated. In this paper, the effects of low concentrations of silver (12 nm) and gold (4.7 nm) nanoparticles coated with polyethylene glycol on Spirulina platensis biomass growth, biochemical composition, and antioxidant activity were investigated. The spirulina cultivation medium was supplemented with nanoparticles in the concentration range of 0.025–0.5 µM. The given concentrations stimulated spirulina biomass, but the content of proteins, carbohydrates, and auxiliary pigments was insignificantly affected by the presence of nanoparticles in the cultivation medium. Gold nanoparticles at a concentration of 0.5 µM produced a pronounced effect on the lipid content. Transmission electron microscope images demonstrated that the nanoparticles penetrate inside the cells and cause ultrastructural changes. The nanoparticles were characterized using several well-known techniques. The results confirmed a negative effect of low concentrations of metal nanoparticles on spirulina. This effect could be indiscernible when studying the biomass viability, but determination of the ultrastructure of the cell and the biochemical composition of the biomass could reveal it.

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Investigating the Role of Shape and Size of Gold Nanoparticles on Their Toxicities to Fungi

Cited by 5 publications

References 27 publications

Limits of Detection of Mycotoxins by Laminar Flow Strips: A Review

Limits of Detection of Mycotoxins by Laminar Flow Strips: A Review

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

Effects of PEG-Coated Silver and Gold Nanoparticles on Spirulina platensis Biomass during Its Growth in a Closed System

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