Investigating the relationship between the severity of coronary artery disease and inflammatory factors of ‎MHR, PHR, NHR, and IL-25

The neutrophil-to-high-density lipoprotein-cholesterol ratio (NHR) is thought to reflect inflammatory status and dyslipidaemia, both of which play significant roles in coronary artery disease (CAD). The objective of this narrative review is to summarise the results of studies that have explored the utility of NHR for the diagnosis and management of CAD. The PubMed, Google Scholar, Scopus, Embase and Web of Science databases were searched for articles related to NHR from their inception to October 2022. Seven relevant articles were obtained for review. There were unclear relationships of NHR with age, sex, smoking status, hypertension and diabetes. However, NHR had a sensitivity and specificity as high as 94.8% and 59%, respectively, for the identification of significant coronary stenosis. NHR was also a superior predictor of prognosis to conventional parameters. NHR had a sensitivity and specificity as high as 77.6% and 74.2%, respectively, for the prediction of adverse events, including mortality, associated with acute coronary syndrome. Thus, NHR could be used in clinical cardiovascular medicine for risk stratification and the prediction of the short-term and long-term outcomes of CAD. However, more studies are required before a quantitative assessment of the efficacy of NHR for use in patient management can be completed.

show abstract

“… 19 Despite this, three studies showed no significant differences between the two patient groups. 6 , 7 , 12 …”

Section: Patient Historymentioning

confidence: 99%

Utility of neutrophil-to-high-density lipoprotein-cholesterol ratio in patients with coronary artery disease: a narrative review

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Due to the inextricable interaction between platelet and HDL-C in the pathogenesis of atherosclerosis, we contemplated that their combination indices would have great clinical significance for improving cardiovascular risk prediction, and should be the subject of intensive investigations both in humans and in animal models. A recent study observes that PLT/HDL-C ratio (PHR) is considered an independent variable for the prediction of the Gensini score in patients with an initial diagnosis of CHD ( 19 ). Another study demonstrates that PHR is significantly increased in patients with nascent metabolic syndrome (MetS) and appears to be a valid biomarker of MetS.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification

Qiu

Luo

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundPlatelet-related parameters and HDL-C have been regarded as reliable and alternative markers of coronary heart disease (CHD) and the independent predictors of cardiovascular outcomes. PDW is a simple platelet index, which increases during platelet activation. Whether the PDW/HDL-C ratio predicts major adverse cardiovascular and cerebrovascular events (MACCEs) in patients who complained of chest pain and confirmed coronary artery calcification remains to be investigated. This study aimed to investigate the prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification.MethodsA total of 5,647 patients with chest pain who underwent coronary computer tomography angiography (CTA) were enrolled in this study. Patients were divided into two groups according to their PDW/HDL-C ratio or whether the MACCE occurs. The primary outcomes were new-onset MACCEs, defined as the composite of all-cause death, non-fatal MI, non-fatal stroke, revascularization, malignant arrhythmia, and severe heart failure.ResultsAll patients had varying degrees of coronary calcification, with a mean CACS of 97.60 (22.60, 942.75), and the level of CACS in the MACCEs group was significantly higher than that in non-MACCE (P<0.001). During the 89-month follow-up, 304 (5.38%) MACCEs were recorded. The incidence of MACCEs was significantly higher in patients with the PDW/HDL-C ratio > 13.33. The K–M survival curves showed that patients in the high PDW/HDL-C ratio group had significantly lower survival rates than patients in the low PDW/HDL-C ratio group (log-rank test: P < 0.001). Multivariate Cox hazard regression analysis reveals that the PDW/HDL ratio was an independent predictor of MACCEs (HR: 1.604, 95% CI: 1.263–2.035; P < 0.001). Cox regression analysis showed that participants with a lower PDW/HDL-C ratio had a higher risk of MACCEs than those in the higher ratio group. The incidence of MACCEs was also more common in the PDW/HDL-C ratio > 13.33 group among different severities of coronary artery calcification. Furthermore, adding the PDW/HDL-C ratio to the traditional prognostic model for MACCEs improved C-statistic (P < 0.001), the NRI value (11.3% improvement, 95% CI: 0.018–0.196, P = 0.01), and the IDI value (0.7% improvement, 95% CI: 0.003–0.010, P < 0.001).ConclusionThe higher PDW/HDL-C ratio was independently associated with the increasing risk of MACCEs in patients with chest pain symptoms and coronary artery calcification. In patients with moderate calcification, mild coronary artery stenosis, and CAD verified by CTA, the incidence of MACCEs increased significantly in the PDW/HDL-C ratio > 13.33 group. Adding the PDW/HDL-C ratio to the traditional model provided had an incremental prognostic value for MACCEs.

show abstract

“… 19 Standard laboratory procedures for quality control were strictly followed. 9–11 , 13 Leukocyte-derived ratios were defined as follows: NLR= NE/LYM, dNLR= NE /[WBC-NE], MLR= MO/LYM, PLR= PLT/LYM, WMR= leukocyte/mean PLT volume, MNM= LYM × NE/10 4 , SIRI= NE × MO/LYM, and SII = PLT/NE/LYM.…”

Section: Methodsmentioning

confidence: 99%

“…19 Standard laboratory procedures for quality control were strictly followed. [9][10][11]13 Leukocyte-derived ratios were defined Hospital professionals also measured the color Doppler ultrasound of the carotid artery after the patient was rested in a supine position for approximately 15 min. Bilateral common carotid arteries, bifurcation, and the internal and external carotid arteries were scanned along the direction of the blood vessels to determine the intima-media thickness (IMT).…”

Section: Data Collectionmentioning

confidence: 99%

“…7,8 Coronary AS causes coronary heart disease (CHD) and is accompanied by carotid artery stenosis. [9][10][11] In recent years, several leukocyte-derived ratios, including neutrophil (NE)-to-LYM ratio (NLR), derived NLR (dNLR), MO-to-LYM ratio (MLR), platelet (PLT)-to-LYM ratio (PLR), white blood cell (WBC)-to-mean PLT volume ratio (WMR), LYM × NE/10 4 ratio (MNM), systemic immune inflammation index (SII), and system inflammation response index (SIRI) have attracted the attention of scholars. 12 Hematological indices NLR and MLR can be regarded as significant predictors of all-cause long-term mortality after Off-Pump Coronary Artery Bypass Grafting (OPCAB) revascularization, which may be applied into clinical practice for meticulous postoperative monitoring of patients in higher risk of worse prognosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

Ma¹,

Liu²,

Wang³

et al. 2022

JIR

View full text Add to dashboard Cite

Purpose This study explored the relationship between monocyte-to-lymphocyte ratio (MLR) as well as other leukocyte-derived ratios and carotid plaques in patients with coronary heart disease (CHD). Patients and Methods A total of 12,093 patients with CHD were selected as research participants. Leukocyte-derived ratios assessed in this study included neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), MLR, platelet-to-lymphocyte ratio (PLR), white blood cell-to-mean platelet volume ratio (WMR), lymphocyte×neutrophil/10 4 ratio (MNM), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI). Leukocyte-derived ratios were divided into four groups according to quarters. Logistic regression analysis was performed to evaluate the relationship between leukocyte-derived ratios and the incidence, number, and echo characteristics of carotid plaques in patients with CHD. Further analysis was performed after adjusting for confounding factors. Results Among the 12,093 participants, 71.7% had carotid plaques. After adjusting for confounding factors, MLR, NLR, dNLR, PLR, SII, SIRI, and WMR were found to be associated with carotid plaque formation. Among them, MLR had the strongest association with the incidence of carotid plaques (odd ratio[OR]:1.889; 95% confidence interval[CI]:1.406–2.539) and hyperechoic plaques (OR:2.024; 95% CI:1.481–2.767). When MLR was viewed as a categorical variable, the risk of carotid plaque formation in Q4 was 1.4 times higher than that in Q1. The relationship between MLR and carotid plaques in females (OR:2.250; 95% CI:1.458–3.473) was stronger than that in males (OR: 1.638; 95% CI:1.102–-2.436). The relationship between MLR and carotid plaques in patients younger than 65 years (OR:3.597; 95% CI:2.379–5.439) was stronger than that in those older than 65 years (OR:1.577; 95% CI:1.046–2.378). Conclusion Leukocyte-derived ratios were related to the incidence, number, and echo characteristics of carotid plaques. In particular, MLR, an inflammatory biomarker that encompasses innate and adaptive immunity, may be of great value in revealing the incidence and echo characteristics of plaques.

show abstract

Investigating the relationship between the severity of coronary artery disease and inflammatory factors of ‎MHR, PHR, NHR, and IL-25

Abstract: Background role of inflamm disease and inf (NHR), and IL Methods: In Farshchian hea 25 were measu history of hype Statistical anal multiple linear Results: The Gensini score ( hypertension, h Conclusion: coronary artery profiles, predic patients prone t

Cited by 14 publications

References 29 publications

Utility of neutrophil-to-high-density lipoprotein-cholesterol ratio in patients with coronary artery disease: a narrative review

Utility of neutrophil-to-high-density lipoprotein-cholesterol ratio in patients with coronary artery disease: a narrative review

Prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification

Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study

Contact Info

Product

Resources

About