Investigating the<i>in vitro</i>effect of taurine on the infant lymphocytes by sister chromatid exchange

Ergün, Mehmet Ali; Soysal, Yasemin; Kısmet, Erol; Akay, Cemal; Dündaröz, Ruşen; İlhan, Mustafa; İmirzalıoğlu, Necat

doi:10.1111/j.1442-200x.2006.02205.x

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that taurine exhibits a protective effect against cellular-stress induced oxidation [ 8 , 14 ]. Indeed, taurine behaves as a free radical scavenger in various cells and tissues [ 9 - 11 , 14 ]. The protective effects of taurine against cytotoxicity and oxidative stress have been observed in cells and tissues, both in vivo and in vitro [ 8 , 9 , 11 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, taurine behaves as a free radical scavenger in various cells and tissues [ 9 - 11 , 14 ]. The protective effects of taurine against cytotoxicity and oxidative stress have been observed in cells and tissues, both in vivo and in vitro [ 8 , 9 , 11 , 14 ]. Since we think that cytotoxic oxygen metabolites are important in the mechanism of RPE, we aimed to investigate the possible beneficial protective effects of taurine in RPE in rats.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective efficiacy of taurine against pulmonary edema progression: experimental study

Yücel

Kunak

Macit

et al. 2008

J Cardiothorac Surg

View full text Add to dashboard Cite

Re-expansion pulmonary edema (RPE) is an acute, rare and potentially lethal complication [1,2]. Its beginning is sudden and dramatic. The mechanism is not yet fully understood [1]. Some authors suggest that it may occur after rapid re-inflation of a collapsed lung [1]. It was reported by other authors that it may relate to surfactant depletion or may result from hypoxic capillary damage, leading to increased capillary permeability [1,3]. In RPE, unilateral lung injury is initiated by cytotoxic oxygen metabolites and temporally associated with an influx of polymorphonuclear neutrophils [1]. These toxic oxygen products are the results of re-oxygenation of a collapsed lung. Treatment of re-expansion pulmonary edema is basically preventive [4].

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective efficiacy of taurine against pulmonary edema progression: experimental study

Yücel

Kunak

Macit

et al. 2008

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?

et al. 2007

View full text Add to dashboard Cite

We examined the effects of beta-alanine (taurine analogue and taurine transport antagonist), taurine (regarding its role in neutrophil (PMN) immunonutrition) and taurine combined either with L-NAME (inhibitor of *NO-synthase), SNAP (*NO donor), DON (glutamine-analogue and inhibitor of glutamine-requiring enzymes), DFMO (inhibitor of ornithine-decarboxylase) and beta-alanine on neutrophil amino- and alpha-keto acid profiles or important PMN immune functions in order to establish whether taurine transport-, nitric oxide-, glutamine- or ornithine-dependent mechanisms are involved in any of the taurine-induced effects. According to the present findings, the taurine-mediated effect appears to be based primarily on a modulation of important transmembraneous transport mechanisms and only secondarily on directly or indirectly induced modifications in intragranulocytic amino- and alpha-keto acid homoeostasis or metabolism. Although a direct relation to the parallel observed immunological modifications can only be presumed, these results show very clearly that compositional modifications in the free intragranulocytic amino- and alpha keto-acid pools coinciding with changes in intragranulocytic taurine levels are relevant metabolic determinants that can significantly influence the magnitude and quality of the granulocytic immune response.

show abstract

Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice

Fuente

Hernánz

Viniegra

et al. 2011

International Immunopharmacology

View full text Add to dashboard Cite

Investigating thein vitroeffect of taurine on the infant lymphocytes by sister chromatid exchange

Abstract: The results indicated that taurine plays a protective role in MMC-induced sister chromatid exchange in human lymphocytes. The authors suggest that the high levels of taurine found in human milk may induce protecting effects from breast-feeding against DNA damage and malignancy.

Cited by 4 publications

References 15 publications

Protective efficiacy of taurine against pulmonary edema progression: experimental study

Protective efficiacy of taurine against pulmonary edema progression: experimental study

Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?

Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice

Contact Info

Product

Resources

About