Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate ‌ on HCT-116 cell line

Abdali, Maede Hasan; Afshar, Saeid; Pashaki, Abdolazim Sedighi; Dastan, Dara; Gholami, Mohammad Hadi; Mahmoudi, Roghayeh; Saidijam, Massoud

doi:10.1016/j.bmc.2019.115152

Cited by 24 publications

(2 citation statements)

References 38 publications

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“…The wavelength of 570 nm was used to measure the optical density (OD). All results in MTT assays were repeated three times, and IC 50 (inhibitory concentration 50%) was calculated according to our previous study (24).…”

Section: Mtt Assaymentioning

confidence: 99%

Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

Dastan

Mahmoudi

Saidijam

et al. 2021

Jentashapir J Cell Mol Biol

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: This study aimed to evaluate the chemical composition and anticancer activity of Hamadan propolis essential oil and methanolic extract on HCT116 cell line. The anticancer activity of propolis methanolic extract and essential oil was evaluated by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) test on the colorectal HCT116 cell line. The essential oil of Hamadan propolis was analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The total flavonoid and phenolic content of methanolic extract were assessed using the aluminum chloride colorimetric procedures and Folin-Ciocalteu (F-C) assay, respectively. The results of MTT assay confirmed the anticancer properties of Hamadan propolis essential oil and methanolic extract on the HCT116 cell line. Moreover, 30 compounds were characterized from Hamadan propolis essential oil, the main compounds of which included β-udesmol (25.7%), α-udesmol (20.4%), α-copaen-11-ol (13.7%), and γ-udesmol (10.1%). In addition, the total flavonoid content and total phenolic content of the methanolic extract were 14.12 mg/g and 32.01 mg/g dry weight, respectively. In summary, the most important constituents of Hamadan propolis essential oil were β-u desmol, α-eudesmol, α-copaen, and γ-u desmol. Despite the cytotoxic effects of Hamadan propolis methanolic extract and essential oil on HCT116, further evaluation of anticancer effects of the most important constituents of propolis methanolic extract and essential oil is recommended.

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Section: Mtt Assaymentioning

confidence: 99%

Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

Dastan

Mahmoudi

Saidijam

et al. 2021

Jentashapir J Cell Mol Biol

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“…In this case, patients can be kept hopeful about treatment, and even the side effects of treatment, which are another concern, can be reduced. In the field of treatment, the most important concerns have been increasing the bioavailability of therapeutic agents and reducing the side effects of therapies [ 1 , 2 ]. In most parts of the world, most conventional chemotherapies are prescribed systemically, and after a while, due to unpleasant side effects such as systemic manifestations or drug resistance, they are stopped, and in most cases, there are no suitable alternatives [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the role of peptides in effective therapies against cancer

2022

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Early diagnosis and effective treatment of cancer are challenging. To diagnose and treat cancer effectively and to overcome these challenges, fundamental innovations in traditional diagnosis and therapy are necessary. Peptides can be very helpful in this regard due to their potential and diversity. To enhance the therapeutic potential of peptides, their limitations must be properly identified and their structures engineered and modified for higher efficiency. Promoting the bioavailability and stability of peptides is one of the main concerns. Peptides can also be effective in different areas of targeting, alone or with the help of other therapeutic agents. There has been a lot of research in this area, and the potential for variability of peptides will continue to improve this process. Another promising area in which peptides can help treat cancer is peptide vaccines, which are undergoing promising research, and high throughput technologies can lead to fundamental changes in this area. Peptides have been effective in almost all areas of cancer treatment, and some have even gone through clinical phases. However, many barriers need to be overcome to reach the desired point. The purpose of this review is to evaluate the mechanisms associated with peptides in the diagnosis and treatment of cancer. Therefore, related studies in this area will be discussed.

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Curcumin inhibits the development of colorectal cancer via regulating the USP4/LAMP3 pathway

Wei,

Li,

Liu

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate ‌ on HCT-116 cell line

Cited by 24 publications

References 38 publications

Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

Investigating the role of peptides in effective therapies against cancer

Curcumin inhibits the development of colorectal cancer via regulating the USP4/LAMP3 pathway

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