Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases (Mpro)

Catecholamine Derivatives: Natural Occurrence, Structural Diversity, and Biological Activity

“…Pereira et al, with the aid of in silico virtual screening, found that lamellarin Z (225) and three other lamellarins were promising potential Mpro inhibitors. 155 Further, it was also proposed that rigid fused polycyclic ring systems, particularly aromatic F-and A-rings, and phenols are essential structural features for protein−ligand interaction (Figure 23). Considering recent success in synthetic lamellarins, 156 these motivating results need further in vitro and in vivo antiviral examinations.…”

“…Viral main proteases (Mpro) are important drug targets due to their important roles in viral replication processes. Pereira et al, with the aid of in silico virtual screening, found that lamellarin Z ( 225 ) and three other lamellarins were promising potential Mpro inhibitors . Further, it was also proposed that rigid fused polycyclic ring systems, particularly aromatic F- and A- rings, and phenols are essential structural features for protein–ligand interaction (Figure ).…”

“…Figure 23. Structure−activity relationships of marine lamellarins pyrrole alkaloids targeting SARS-CoV-2 and Zika Mpro via computeraided virtual screening 155. …”

Recent advances in the synthesis of chromenone fused pyrrolo[2,1-a]isoquinoline derivatives

“…In a recent study, it was reported that marine polycyclic lamellarin pyrrole alkaloids exhibit promising inhibitory activities for SARS-CoV-2 and Zika main proteases (Mpro). 44 Owing to their wide array of biological properties and the quite limited supply from natural sources, the syntheses of such analogues have become an interesting research topic in the field of medicinal chemistry and organic chemistry. With the recent development of new reagents and reaction systems, organic chemists have established numerous powerful methods for the total synthesis of such natural products and their isomers.…”

Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis

“…21,22 The high diversity of the secondary metabolites produced by the genus of Sarcophyton resulted in displaying wide spectrum of intriguing pharmacological activities including anti-inammatory, cytotoxicity, antimicrobial, anti-angiogenic, neuroprotective, immunomodulatory, ichthyotoxic, antitumor and antifouling. 13,20,24 As a part of our continuing research program to identify pharmacologically active natural products, 4,15,[28][29][30][31] here, we detail the isolation and structural elucidation of three steroidcontaining metabolites from the Red Sea so coral organic extract Sarcophyton glaucum, which was collected from the reefs of Hurghada, Egypt. Additionally, to provide valuable insights into nding the most promising marine steroids obtained from the Red Sea so coral S. glaucum organic extract as hepatoprotective agents for liver disorder, a computational approach was employed, including molecular docking (MDock) and analysis of structure-activity relationship (SAR) against glutathione-S-tranferase (PDB ID 18GS) and Cu-Zn human superoxide dismutase (PDB ID 2C9V).…”