Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis

Tammam, Mohamed A.; Pereira, Florbela; Aly, Omnia; Sebak, Mohamed; Diab, Yasser M.; Mahdy, Aldoushy; El-Demerdash, Amr

doi:10.1039/d3ra04843h

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…The effects were assessed by detecting liver function parameters, tumor markers and gene expression in liver tissues, as well as by observing pathological changes in liver tissues. Moreover, the interaction of marine steroids with the detoxification enzymes glutathione S-transferase (GST) and SOD were investigated computationally, and two promising steroid modulators were identified, dissesterol (23) and glaucasterol (24), that have good binding ability to GST and SOD, in addition to the double bond on the B ring of the tetracyclic steroid system in the structure and the cyclopropane ring on the side chain, which seem to be the key structural elements for the enhancement of hepatic protective activity of the tetracyclic steroid system [76].…”

Section: Liver Fibrosismentioning

confidence: 99%

Effects of Marine Natural Products on Liver Diseases

Sun,

Dong,

Cui

et al. 2024

Marine Drugs

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The prevention and treatment of liver disease, a class of disease that seriously threatens human health, has always been a hot topic of medical research. In recent years, with the in-depth exploration of marine resources, marine natural products have shown great potential and value in the field of liver disease treatment. Compounds extracted and isolated from marine natural products have a variety of biological activities such as significant antiviral properties, showing potential in the management of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), protection of the liver from fibrosis, protection from liver injury and inhibition of the growth of hepatocellular carcinoma (HCC). This paper summarizes the progress of research on marine natural products for the treatment of liver diseases in the past decade, including the structural types of active substances from different natural products and the mechanisms underlying the modulation of different liver diseases and reviews their future prospects.

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Section: Liver Fibrosismentioning

confidence: 99%

Effects of Marine Natural Products on Liver Diseases

Sun,

Dong,

Cui

et al. 2024

Marine Drugs

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Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats

Mekawy,

Sabry,

Sabry

et al. 2024

Mol Biol Rep

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Background TGF-β1 and SMAD3 are particularly pathogenic in the progression of renal fibrosis. Aim This study aimed to evaluate the kidney protective potentials of silymarin (SM) and exosomes of mesenchymal stem cells against the nephrotoxin thioacetamide (TAA) in rats. Methods 32 female rats were randomly assigned into four groups: the control group, the TAA group, the TAA + SM group, and the TAA + Exosomes group. The kidney homogenates from all groups were examined for expression levels of TGF-β receptors I and II using real-time PCR, expression levels of collagen type I and CTGF proteins using ELISA, and the expression levels of nuclear SMAD2/3/4, cytoplasmic SMAD2/3, and cytoplasmic SMAD4 proteins using the western blot technique. Results Compared to the control group, the injection of TAA resulted in a significant increase in serum levels of urea and creatinine, gene expression levels of TβRI and TβRII, protein expression levels of both collagen I and CTGF proteins, cytoplasmic SMAD2/3 complex, and nuclear SMAD2/3/4 (p-value < 0.0001), with significantly decreased levels of the co-SMAD partner, SMAD4 (p-value < 0.0001). Those effects were reversed considerably in both treatment groups, with the superiority of the exosomal treatment regarding the SMAD proteins and the expression levels of the TβRI gene, collagen I, and CTGF proteins returning to near-control values (p-value > 0.05). Conclusion Using in vitro and in vivo experimental approaches, the research discovered a reno-protective role of silymarin and exosomes of BM-MSCs after thioacetamide-induced renal fibrosis in rats, with the advantage of exosomes.

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Cephalostatins and ritterazines: Distinctive dimeric marine-derived steroidal pyrazine alkaloids with intriguing anticancer activities

Tammam,

Gamal El-Din,

Aouidate

et al. 2024

Bioorganic Chemistry

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Investigating the hepatoprotective potentiality of marine-derived steroids as promising inhibitors of liver fibrosis

Abstract: The present study investigates multiple interactions of a series of marine steroids with glutathione-S-transferase (GST) and Cu–Zn human superoxide dismutase (Cu–ZnSOD) enzymes, in order to reveal insights into the process of hepatoprotection.

Cited by 4 publications

References 58 publications

Effects of Marine Natural Products on Liver Diseases

Effects of Marine Natural Products on Liver Diseases

Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats

Cephalostatins and ritterazines: Distinctive dimeric marine-derived steroidal pyrazine alkaloids with intriguing anticancer activities

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