2018
DOI: 10.1155/2018/8635329
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: The prevalence of hepatocellular carcinoma (HCC) is still high worldwide because liver diseases could develop into HCC. Recent reports indicate nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NAFLD&NASH) and primary biliary cirrhosis and primary sclerosing cholangitis (PBC&PSC) are significant of HCC. Therefore, understanding the cellular mechanisms of the pathogenesis and hepatocarcinogenesis from normal liver cells to HCC through NAFLD&NASH or PBC&PSC is a priority to prevent the progressi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
7
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 11 publications
(7 citation statements)
references
References 55 publications
0
7
0
Order By: Relevance
“…Finally, co-expression analysis showed that HIST1H2BK was positively associated with HIST1H2AG, HIST2H2AA4, HIST1H2BJ, HIST2H2BE, and HIST1H2AC, and was negatively associated with PDZD4, CRY2, GABBR1, RP5-1119A7.17, and KCNJ11. As previously reported, HIST2H2BE may be a promising drug target that could mitigate autoimmune deficiency (40). Moreover, co-immunoprecipitation of HNRNP-K with SERPINA3 correlated with levels of HIST2H2BE transcripts and telomere length in hepatocellular carcinoma (HCC) tissues (41).…”
Section: Discussionmentioning
confidence: 65%
“…Finally, co-expression analysis showed that HIST1H2BK was positively associated with HIST1H2AG, HIST2H2AA4, HIST1H2BJ, HIST2H2BE, and HIST1H2AC, and was negatively associated with PDZD4, CRY2, GABBR1, RP5-1119A7.17, and KCNJ11. As previously reported, HIST2H2BE may be a promising drug target that could mitigate autoimmune deficiency (40). Moreover, co-immunoprecipitation of HNRNP-K with SERPINA3 correlated with levels of HIST2H2BE transcripts and telomere length in hepatocellular carcinoma (HCC) tissues (41).…”
Section: Discussionmentioning
confidence: 65%
“… 47 Moreover, methylation of RPL30 downregulated the dysfunction of anti-apoptosis that is involved in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pathways, which could lead to hepatocarcinogenesis. 48 In head and neck squamous cell carcinoma, RPL30 and other genes 49 were determined as the internal core genes with stable expression. SEC61A1 , as a hallmark DNA repair gene, was identified as a potential independent indicator of prognosis in hepatocellular carcinoma in a gene-wide association study.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the 5-year survival rates of HCC ranges from 3 to 28%. (Li et al, 2018). Most patients with HCC are at intermediate or advanced stages when diagnosed and are not suitable for surgical treatment (Wu et al, 2020a).…”
Section: Introductionmentioning
confidence: 99%