Investigating Effects of Superparamagnetic Iron Oxide Nanoparticles on Candida albicans Biofilm Formation

Golipour, Fateme; Habibipour, Reza; Moradihaghgou, Leila

doi:10.29252/mlj.13.6.44

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…In addition, zinc oxide nanoparticles (ZnO-NPs) used on Candida biofilm showed a decrease in the biofilm formation by abot 62%-85% at varied concentration of 125 ppm to 250 ppm respectively. The ZnO-NPs suggested to inhibit hyphae formation in C. albicans by production of reactive oxygen species in a dose-dependent manner (Hosseini et al, 2018;Golipour et al, 2019;Mahamuni-Badiger et al, 2020). Additionally, another study involving copper oxide nanoparticles (Cu 2 ONP and CuONP) showed potent inhibitory action against biofilm formation by C. albicans.…”

Section: Recent Advances To Inhibit C Albicans Biofilm Formationmentioning

confidence: 99%

Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition

et al. 2021

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In recent years, the demand for novel antifungal therapies has increased several- folds due to its potential to treat severe biofilm-associated infections. Biofilms are made by the sessile microorganisms attached to the abiotic or biotic surfaces, enclosed in a matrix of exopolymeric substances. This results in new phenotypic characteristics and intrinsic resistance from both host immune response and antimicrobial drugs. Candida albicans biofilm is a complex association of hyphal cells that are associated with both abiotic and animal tissues. It is an invasive fungal infection and acts as an important virulent factor. The challenges linked with biofilm-associated diseases have urged scientists to uncover the factors responsible for the formation and maturation of biofilm. Several strategies have been developed that could be adopted to eradicate biofilm-associated infections. This article presents an overview of the role of C. albicans biofilm in its pathogenicity, challenges it poses and threats associated with its formation. Further, it discusses strategies that are currently available or under development targeting prostaglandins, quorum-sensing, changing surface properties of biomedical devices, natural scaffolds, and small molecule-based chemical approaches to combat the threat of C. albicans biofilm. This review also highlights the recent developments in finding ways to increase the penetration of drugs into the extracellular matrix of biofilm using different nanomaterials against C. albicans.

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Section: Recent Advances To Inhibit C Albicans Biofilm Formationmentioning

confidence: 99%

Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition

et al. 2021

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“…The antimicrobial activity of IONPs has also been proven against fungal species, such as C. albicans [ 33 , 88 , 89 ]. While there are concerns related to biocompatibility and toxicity, these characteristics can be modified by altering their size, shape, stability, and coating [ 90 ].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

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Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10–100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.

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“…Multiple antifungal agents have been developed to date on the basis of metal nanoparticles (NPs) and/or metal-organic frameworks (MOFs) (Table 1, [11,12,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Figure 1).…”

Section: Antifungal Agents Based On Metal Nanoparticles Metal-organic...mentioning

confidence: 99%

“…Relatively easily accessible metals, like Zn [24,[26][27][28][29] and Fe [30,31] and their oxides, are dominantly used to produce antifungal NPs (Figure 1). Such metals are also a little bit more tolerable to non-target organisms.…”

Section: Metal Npsmentioning

confidence: 99%

Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity

Lyagin

Aslanli

Domnin

et al. 2023

IJMS

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Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized and naturally obtained variants as a result of the so-called “green synthesis”. The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. Various hydrolytic enzymes (glucanases and proteases), in turn, exhibit antifungal properties by affecting the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal own protective agents (mycotoxins and antibiotics), and proteins responsible for the adhesion and formation of stable, highly concentrated populations in the form of biofilms. A wide substrate range of enzymes allows the use of various mechanisms of their antifungal actions. In this review, we discuss the prospects of combining two different types of antifungal agents (metals and enzymes) against mycelial fungi and yeast cells. Special attention is paid to the possible influence of metals on the activity of the enzymes and the possible effects of proteins on the antifungal activity of metal-containing compounds.

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Investigating Effects of Superparamagnetic Iron Oxide Nanoparticles on Candida albicans Biofilm Formation

Cited by 11 publications

References 34 publications

Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition

Mechanistic Understanding of Candida albicans Biofilm Formation and Approaches for Its Inhibition

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity

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