Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity

Lyagin, Ilya; Aslanli, Aysel; Domnin, Maksim; Stepanov, Nikolay; Senko, Olga; Maslova, Olga; Ефременко, Елена

doi:10.3390/ijms241411359

Cited by 8 publications

(4 citation statements)

References 164 publications

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“…Among the antifungals that can be used in effective combination with AFPs, metalcontaining compounds and enzymes are discussed [146,147]. The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of ROS.…”

Section: Combination Of Antifungal Peptides With Each Other And/or Wi...mentioning

confidence: 99%

Various Biomimetics, Including Peptides as Antifungals

Efremenko,

Aslanli,

Stepanov

et al. 2023

Biomimetics

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Biomimetics, which are similar to natural compounds that play an important role in the metabolism, manifestation of functional activity and reproduction of various fungi, have a pronounced attraction in the current search for new effective antifungals. Actual trends in the development of this area of research indicate that unnatural amino acids can be used as such biomimetics, including those containing halogen atoms; compounds similar to nitrogenous bases embedded in the nucleic acids synthesized by fungi; peptides imitating fungal analogs; molecules similar to natural substrates of numerous fungal enzymes and quorum-sensing signaling molecules of fungi and yeast, etc. Most parts of this review are devoted to the analysis of semi-synthetic and synthetic antifungal peptides and their targets of action. This review is aimed at combining and systematizing the current scientific information accumulating in this area of research, developing various antifungals with an assessment of the effectiveness of the created biomimetics and the possibility of combining them with other antimicrobial substances to reduce cell resistance and improve antifungal effects.

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Section: Combination Of Antifungal Peptides With Each Other And/or Wi...mentioning

confidence: 99%

Various Biomimetics, Including Peptides as Antifungals

Efremenko,

Aslanli,

Stepanov

et al. 2023

Biomimetics

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“…It can be expected that future developments in this field may be based on using combinations of enzymes with metal-containing catalysts for HF. This approach can simultaneously lead to improvements in the decomposition of AW and the detoxification of treated media contaminated with mycotoxins [83].…”

Section: Compostingmentioning

confidence: 99%

Artificial Humic Substances as Biomimetics of Natural Analogues: Production, Characteristics and Preferences Regarding Their Use

Efremenko,

Stepanov,

Senko

et al. 2023

Biomimetics

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Various processes designed for the humification (HF) of animal husbandry wastes, primarily bird droppings, reduce their volumes, solve environmental problems, and make it possible to obtain products with artificially formed humic substances (HSs) as analogues of natural HSs, usually extracted from fossil sources (coal and peat). This review studies the main characteristics of various biological and physicochemical methods of the HF of animal wastes (composting, anaerobic digestion, pyrolysis, hydrothermal carbonation, acid or alkaline hydrolysis, and subcritical water extraction). A comparative analysis of the HF rates and HS yields in these processes, the characteristics of the resulting artificial HSs (humification index, polymerization index, degree of aromaticity, etc.) was carried out. The main factors (additives, process conditions, waste pretreatment, etc.) that can increase the efficiency of HF and affect the properties of HSs are highlighted. Based on the results of chemical composition analysis, the main trends and preferences with regard to the use of HF products as complex biomimetics are discussed.

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“…Among antifungals that can be used in effective combination with AFPs, metal-containing compounds and enzymes are discussed [141,142]. The main mechanism of the antifungal action of metals is the triggering of generation and accumulation of ROS.…”

Section: Combination Of Antifungal Peptides With Each Other And/or Wi...mentioning

confidence: 99%

Various Biomimetics as Antifungals

Efremenko,

Aslanli,

Stepanov

et al. 2023

Preprint

View full text Add to dashboard Cite

Biomimetics, which are similar to natural compounds that play an important role in the metabolism, manifestation of functional activity and reproduction of various fungi, have a pronounced attrac-tion in the current search for new effective antifungals. Actual trends in the development of this area of research indicate that unnatural amino acids can be used as such biomimetics, including those containing halogen atoms; compounds similar to nitrogenous bases embedded in the nucleic acids synthesized by fungi; peptides imitating fungal analogues; molecules similar to natural sub-strates of numerous fungal enzymes and Quorum Sensing signaling molecules of fungi and yeast; etc. Most part of the review is devoted to the analysis of semi-synthetic and synthetic antifungal peptides and their targets of action. This review is aimed at combining and systematizing the cur-rent scientific information accumulating in this area of research, developing various antifungals with an assessment of the effectiveness of the created biomimetics and the possibility of combining them with other antimicrobial substances to reduce cell resistance and improve antifungal effects.

show abstract

Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity

Cited by 8 publications

References 164 publications

Various Biomimetics, Including Peptides as Antifungals

Various Biomimetics, Including Peptides as Antifungals

Artificial Humic Substances as Biomimetics of Natural Analogues: Production, Characteristics and Preferences Regarding Their Use

Various Biomimetics as Antifungals

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