Exploring the effect of climate change and human activities on vegetation is a key requisite for the reconstruction of regional ecological environments. Therefore, based on long‐term vegetation GIMMS Normalized Difference Vegetation Index (NDVI) data, climate data, and statistical data, the present study applied the Hasse diagram technique and combined the multivariate regression residual analysis to quantitatively analyze the impact of human activities and climate change on vegetation in Inner Mongolia from detailed human activities with some innovations. The results show that (1) NDVI shows an overall increasing trend over the last 39 years, with an abrupt change in 2000; moreover, vegetation growth was better before the abrupt change (PI: 1982–2000) than after it (PII: 2001–2020), with significant downward trends in Xilin Gol and Hulunbuir. (2) Human activities can promote as well as inhibit vegetation, and the promotion effect was larger during 1982–2000 than during 2001–2020, whereas the inhibition effect was larger during 2001–2020. In addition, during PI, vegetation in Inner Mongolia generally experienced promotion by human activities and climate change, while during PII, climate‐driven promotion had the strongest effect, followed by human‐driven inhibition mainly distributed in Xilin Gol. (3) The result of the Hasse diagram analysis shows that the dominant pathways of human activities affecting most of the cities were economic factors and urbanization during PI and economization during PII.