In this article we analyze the global diffeomorphism property of polynomial maps F : R n → R n by studying the properties of the Newton polytopes at infinity corresponding to the sum of squares polynomials F 2 2 . This allows us to identify a class of polynomial maps F for which their global diffeomorphism property on R n is equivalent to their Jacobian determinant det JF vanishing nowhere on R n . In other words, we identify a class of polynomial maps for which the Real Jacobian Conjecture, which was proven to be false in general, still holds.