Inverted papilloma of the ureter: study of a rare case with emphasis on clinicopathologic implications

Abstract

A 62-year old male patient presented complaining of intermittent macroscopic hematuria. The ultrasonographic investigation revealed a hydronephrosis of remarkable degree with indiscrete renal parenchyma. The abdominal computed tomography scan identified a ureteral lesion with proximal dilatation, hydronephrosis and a functionless ipsilateral renal unit. The retrograde urography showed a 4-cm lesion with multiple filling defects and a smooth contour. The endoscopic examination showed an exophytic lesion, highly suspicious for malignancy. Urine cytology revealed atypia. Right nephroureterectomy was performed and the pathology revealed a ureteral inverted papilloma (UIP). Polymerase chain reaction examination for the presence of human papilloma virus, using GP5+/6+ consensus primers, was negative. The presence UIP should be considered in patients with urotheleal lesions in the ureter when the diagnostic workup for malignancy is inconclusive. The clinical course of the disease seems to be favorable.

Az invertált papilloma bemutatása egy ritka eset kapcsán = Presentation of a rare case of inverted papilloma

“…Képalkotó vizsgálatok alapján, a tumor többnyire rövid nyéllel rendelkezik, a hólyag űrterébe beboltosul, a felszíne általában sima, azonban széles alapon ülő, szesszilis morfológiájú eseteket is leírtak. Az IUP általában kicsi, legfeljebb 3 cm átmérőjű tumor, azonban nagyobb méretű, akár 8 cm átmérőjű esetek is ismertek (5). Tünetei változatosak, nem specifikusak és mindemellett gyakran tünetmentes is maradhat.…”