Invertebrate Host-Parasite Relationships: Convergent Evolution of a Tropomyosin Epitope Between Schistosoma Sp, Fasciola hepatica, and Certain Pulmonate Snails

Weston, David S.; Allen, B.; Thakur, Aditya; LoVerde, Philip T.; Kemp, Walter M.

doi:10.1006/expr.1994.1028

Cited by 13 publications

(9 citation statements)

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“…Over the past two decades, several investigators have demonstrated the antigenic community between S. mansoni and Biomphalaria (Dissous et al 1986, 1990, Iwanaga et al 1992, Iwanaga 1994, Weston et al 1994). …”

Section: Discussionmentioning

confidence: 99%

“…Common antigens between different species of Schistosoma and their intermediate hosts have been reported (Dissous et al 1986, Iwanaga 1994, Weston et al 1994, Gamal-Eddin et al 1996, 1997. We demonstrated that sera from schistosome-infected persons reacted against soluble crude Biomphalaria glabrata antigen (SBgA) by ELISA (100% of sensitivity) (Alarcón de Noya et al 1989) and that sera from mice immunized with SBgA recognized several homologous snail molecules by Western-blot .…”

mentioning

confidence: 90%

“…

AWA (16, 30, 36, 60 and 155 kDa (Dissous et al 1986, Iwanaga 1994, Weston et al 1994, Gamal-Eddin et al 1996, 1997. We demonstrated that sera from schistosome-infected persons reacted against soluble crude Biomphalaria glabrata antigen (SBgA) by ELISA (100% of sensitivity) (Alarcón de Noya et al 1989) and that sera from mice immunized with SBgA recognized several homologous snail molecules by Western-blot .

Cross-reactive antigens may probably result from the adaptation of parasites to their invertebrate and vertebrate hosts and in consequence, could prevent immune recognition in the latter.

…”

mentioning

confidence: 99%

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Antigenic community between Schistosoma mansoni and Biomphalaria glabrata: on the search of candidate antigens for vaccines

Chacón

Losada

Noya

et al. 2002

Mem. Inst. Oswaldo Cruz

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AWA (16, 30, 36, 60 and 155 kDa (Dissous et al. 1986, Iwanaga 1994, Weston et al. 1994, Gamal-Eddin et al. 1996, 1997. We demonstrated that sera from schistosome-infected persons reacted against soluble crude Biomphalaria glabrata antigen (SBgA) by ELISA (100% of sensitivity) (Alarcón de Noya et al. 1989) and that sera from mice immunized with SBgA recognized several homologous snail molecules by Western-blot .Cross-reactive antigens may probably result from the adaptation of parasites to their invertebrate and vertebrate hosts and in consequence, could prevent immune recognition in the latter. Our basic hypothesis is that the parasite acquires snail molecules on its surface that would cover critical antigens, allowing its survival during skin penetration and the evasion from the protective immune mechanisms of definitive host during the first events of invasion. In the present work, non-singenic mice were immunized with a crude antigen of non-infected B. glabrata in order to demonstrate, first, the cross-reactivity and crossinhibition between S. mansoni and B. glabrata common proteins. Second, to characterize SBgA, particularly its glycoprotein components and third, to determine the protective effect of the crude preparation of B. glabrata in mice against S. mansoni infection.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 90%

“…

Cross-reactive antigens may probably result from the adaptation of parasites to their invertebrate and vertebrate hosts and in consequence, could prevent immune recognition in the latter.

…”

mentioning

confidence: 99%

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Antigenic community between Schistosoma mansoni and Biomphalaria glabrata: on the search of candidate antigens for vaccines

Chacón

Losada

Noya

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…The Schistosoma-Biomphalaria association was the first hostparasite model which demonstrated shared antigens 8,22,43 . Different molecules are cross-reactive and most of them have not been characterized yet.…”

Section: Discussionmentioning

confidence: 99%

“…Other models in which antigenic sharing between parasites and their intermediate hosts (snails) or vectors has been described: S. haematobium, S. japonicum, and Paragonimus westermani, Leishmania major and Phlebotomus duboscqi 9,27,28,33,39,43 . The purpose of this study is to identify shared antigens in another model: An.…”

Section: Discussionmentioning

confidence: 99%

Sharing of antigens between Plasmodium falciparum and Anopheles albimanus

Wide

Capaldo²,

Zerpa

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe presence of common antigens between Plasmodium falciparum and Anopheles albimanus was demonstrated. Different groups of rabbits were immunized with: crude extract from female An. albimanus (EAaF), red blood cells infected with Plasmodium falciparum (EPfs), and the SPf66 synthetic malaria vaccine. The rabbit´s polyclonal antibodies were evaluated by ELISA, Multiple Antigen Blot Assay (MABA), and immunoblotting. All extracts were immunogenic in rabbits according to these three techniques, when they were evaluated against the homologous antigens. Ten molecules were identified in female mosquitoes and also in P. falciparum antigens by the autologous sera. The electrophoretic pattern by SDS-PAGE was different for the three antigens evaluated. Cross-reactions between An. albimanus and P. falciparum were found by ELISA, MABA, and immunoblotting. Anti-P. falciparum and anti-SPf66 antibodies recognized ten and five components in the EAaF crude extract, respectively. Likewise, immune sera against female An. albimanus identified four molecules in the P. falciparum extract antigen. As far as we know, this is the first work that demonstrates shared antigens between anophelines and malaria parasites. This finding could be useful for diagnosis, vaccines, and the study of physiology of the immune response to malaria.

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Identification of proteins in excretory/secretory extracts ofEchinostoma friedi (Trematoda) from chronic and acute infections

et al. 2006

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In the present study, we describe the investigation of Echinostoma friedi excretory/secretory products using a proteomic approach combined with the use of heterologous antibodies. We have identified 18 protein spots corresponding to ten proteins, including cytoskeletal proteins like actin, tropomyosin, and paramyosin; glycolytic enzymes like enolase, glyceraldehyde 3P dehydrogenase, and aldolase; detoxifying enzymes like GSTs; and stress proteins like heat shock protein (Hsp) 70. Among these proteins, both actin and, to a lesser extent, Hsp70, exhibited differential expression patterns between chronic and acute infections in the Echinostoma-rodent model, suggesting that these proteins may play a role in the survival within the host.

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Invertebrate Host-Parasite Relationships: Convergent Evolution of a Tropomyosin Epitope Between Schistosoma Sp, Fasciola hepatica, and Certain Pulmonate Snails

Cited by 13 publications

References 0 publications

Antigenic community between Schistosoma mansoni and Biomphalaria glabrata: on the search of candidate antigens for vaccines

Antigenic community between Schistosoma mansoni and Biomphalaria glabrata: on the search of candidate antigens for vaccines

Sharing of antigens between Plasmodium falciparum and Anopheles albimanus

Identification of proteins in excretory/secretory extracts ofEchinostoma friedi (Trematoda) from chronic and acute infections

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