Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen‐challenged patients with intermittent allergic rhinitis

Benson, Mikael; Fransson, Mattias; Martinsson, Tommy; Naluai, Åsa Torinsson; Uddman, Rolf; Cardell, Lars-Olaf

doi:10.1111/j.1398-9995.2006.01264.x

Cited by 36 publications

(43 citation statements)

References 24 publications

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“…The levels of CC16 are lower in serum and nasal secretions of allergic children in comparison with healthy ones [14]. The concentrations of CC16 in nasal secretions of patients with seasonal allergic rhinitis are lower during the pollen season [11]. The results of one study concerning the role of CC16 in nasal inflammation in patients with PAR showed a positive correlation between the nasal fluid concentrations of CC16 and nasal production of nitric oxide (NO) [15].…”

Section: Discussionmentioning

confidence: 95%

“…Previous investigations showed a suppressive effect of allergic inflammation on CC16 production [9,11,14]. The levels of CC16 are lower in serum and nasal secretions of allergic children in comparison with healthy ones [14].…”

Section: Discussionmentioning

confidence: 99%

“…This mediator is dominantly produced by Clara cells in nasal and bronchoalveolar epithelium [9]. Previous investigations suggest that CC16 has an important role in controlling and inhibition of oxidative stress and inflammatory response in nasal mucosa of patients with seasonal allergic rhinitis (SAR) [10,11]. The anti-inflammatory effect of CC16 is thought to be dependent on the inhibition of pro-inflammatory enzymes phospholipase A2 (PLA2) and transglutaminase.…”

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

“…The anti-inflammatory effect of CC16 is thought to be dependent on the inhibition of pro-inflammatory enzymes phospholipase A2 (PLA2) and transglutaminase. Both these enzymes play a key role in arachidonic acid release during an allergic inflammation [9][10][11]. However, the role of CC16 in regulation of chronic inflammation in patients with PAR has not been fully investigated.…”

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

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Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

et al. 2017

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Objective: Eotaxin-2 and regulated on activation normal T cell expressed and secreted (RANTES) are involved in the eosinophil trafficking in patients with persistent allergic rhinitis (PAR). Clara cell protein 16 (CC16) is an anti-inflammatory protein mainly produced by the epithelial non-ciliated Clara cells. The aim of this study was to investigate the production of CC16 and chemokines eotaxin-2 and RANTES in nasal mucosa of patients with PAR.Materials and Methods: Twenty-one PAR patients and 20 healthy participants were included. CC16, eotaxin-2, and RANTES concentrations were measured in nasal secretions. PAR patients were administered fluticasone furoate nasal spray (220 μg daily for 14 days). We performed nasal cytology, symptom score assessment, and inflammatory mediator detection before and after the therapy.Results: The level of CC16 in patients with PAR was lower than in the healthy subjects (p=0.023). The eosinophil counts and local concentrations of eotaxin-2 and RANTES were higher in patients with PAR in comparison with controls (p=0.008, p=0.001, p=0.031, respectively). We also found a negative correlation between the CC16 and eotaxin-2 levels in nasal secretions of PAR patients (r=−0.492, p=0.023). After corticosteroid therapy, the patients with PAR had lower nasal symptoms, eosinophil counts, eotaxin-2, and RANTES levels and higher levels of CC16 (p<0.001 for all parameters). Conclusion:Our results suggest the presence of a negative correlation in production of CC16 and eotaxin-2 in nasal mucosa of patients with PAR. Intranasal corticosteroids have a suppressive effect on mucosal eosinophilic inflammation and a stimulating effect on local CC16 production.Keywords: Allergic rhinitis, chemokines, eosinophils, glucocorticoids, inflammation mediators ÖZ Amaç: Eotaksin-2 ve RANTES (aktivasyonla regüle edilen, normal T hücresi ekspresyonu ve sekresyonu) persistan alerjik riniti (PAR) olan hastalarda eozinofil göçünde yer almaktadır. Clara hücresi protein 16 (CC16) çoğunlukla sil içermeyen epitelyal hücreler tarafından üretilirler. Bu çalışmanın amacı PAR hastalarının nazal mukozasında CC16 ve eotaksin-2 ve RANTES kemokinlerinin üretimini araştırmaktır. Gereç ve Yöntemler:Çalışmaya 21 PAR hastası ve 20 sağlıklı katılımcı dahil edildi. Nazal sekresyonlardaki CC16, eotaksin-2 ve RANTES seviyeleri ölçüldü. PAR hastalarına flutikazon furoat nazal sprey uygulandı (14 gün boyunca günlük 220 μg doz). Tedavi öncesi ve sonrasında, nazal sitoloji, semptom skoru değerlendirmesi ve inflamatuar mediyatör taraması yapıldı.Bulgular: CC16 seviyesi PAR hastalarında sağlıklı deneklere kıyasla daha düşük bulundu (p=0,023). Kontrollere göre, eozinofil sayıları ve lokal eotaksin-2 ve RANTES seviyeleri PAR hastalarında daha yüksekti (sırasıyla p=0,008, p=0,001, p=0,031). Ayrıca PAR hastalarının nazal sekresyonlarında CC16 ile eotaksin-2 düzeyleri arasında negatif bir korelasyon bulundu (r=-0,492, p=0,023). Kortikosteroid tedavisi sonrasında, PAR hastalarında daha düşük nazal semptomlar, eozinofil sayıları, eotaksin-...

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

Section: Persistan Alerjik Riniti Olan Hastaların Nazal Mukozalarındamentioning

confidence: 99%

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Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

et al. 2017

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“…Data on the global proteome of these fluids are available, leading the path to their use for a biomarker discovery program. Genomic analyses can be carried out on the cells of nasal fluid or biopsy specimens (134)(135)(136).…”

Section: Proteomics and Genomicsmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

167

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

Špadijer-Mirković

Perić

Belic

et al. 2016

Int Forum Allergy Rhinol

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Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen‐challenged patients with intermittent allergic rhinitis

Abstract: There was an inverse relation between nasal fluid CC16 levels and symptoms and signs of rhinitis in allergen-challenged patients with IAR. However, there was no association between IAR and the A38G SNP.

Cited by 36 publications

References 24 publications

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

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Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen‐challenged patients with intermittent allergic rhinitis

Abstract: There was an inverse relation between nasal fluid CC16 levels and symptoms and signs of rhinitis in allergen-challenged patients with IAR. However, there was no association between IAR and the A38G SNP.

Cited by 36 publications

References 24 publications

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

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Product

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper