Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Perić, Aleksandar; Mirković, Cveta Špadijer; Đurđević, Biserka Vukomanović; Vojvodić, Danilo

doi:10.5152/eurasianjmed.2017.17203

Cited by 8 publications

(15 citation statements)

References 26 publications

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“…Our previous investigations showed that inflammation in patients with NPs and allergic rhinitis decreases the levels of CC16 16,23 . We, also, found that the concentration of CC16 in nasal secretions was negatively correlated with the levels of ECP and eotaxin‐2 in patients with NP and perennial allergic rhinitis 16,23,24 . The results of our current study show a negative correlation between CC16 and HSP70, ECP, tryptase, and substance P in nasal secretions, which indicates a significant sensitivity of Clara cells in the nasal respiratory epithelium to a number of pro‐inflammatory mediators that can damage the epithelium.…”

Section: Discussionsupporting

confidence: 71%

“…The results of our current study show a negative correlation between CC16 and HSP70, ECP, tryptase, and substance P in nasal secretions, which indicates a significant sensitivity of Clara cells in the nasal respiratory epithelium to a number of pro‐inflammatory mediators that can damage the epithelium. After topical corticosteroid use, the concentrations of CC16 increased in both allergic rhinitis and NP patients, suggesting that CC16 measured in nasal secretions could be a reliable marker for assessment of the recovery function of sinonasal mucosa during local corticosteroid therapy 16,24 …”

Section: Discussionmentioning

confidence: 99%

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Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Dimić

Perić

Grgurević

et al. 2022

Laryngoscope Investig Oto

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Objectives: Biomarker levels in nasal secretions can reflect the inflammatory status of nasal mucosa and evolution of sinus disease. The aim of this study was to evaluate the relationship between local inflammatory mediator production and clinical characteristics of patients with nasal polyposis (NP).Methods: Thirty-one nonaeroallergen sensitized patients with NP (NANP), 29 aeroallergen sensitized patients with NP (ANP), and 30 subjects without inflammation of nasal mucosa as controls (C) entered this prospective, cross-sectional study.Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed.The concentrations of heat shock protein 70 (HSP70), eosinophil cationic protein (ECP), tryptase, substance P and Clara cell protein 16 (CC16) were measured in the nasal secretion samples of all participants by ELISA method.Results: Our results showed higher concentrations of HSP70, ECP, and tryptase in ANP than in NANP and C (p < .001 for all markers). On the other hand, levels of CC16 were significantly higher in C than in NANP and ANP groups (p < .001; p < .001, respectively). We found positive correlations between HSP70, ECP, tryptase, and substance P levels and nasal symptom score in patients with NP. Also, HSP70, ECP, tryptase, and substance P showed different levels of positive correlation among themselves, with HSP70 showing highest positive correlation with ECP.Finally, relatively strong negative correlations were found between the levels of CC16 and nasal symptoms, as well as between the CC16 levels and levels of other four mediators in nasal fluid.Conclusion: HSP70, ECP, tryptase, and substance P might play a role in the pathogenesis of NP. The results suggest that chronic inflammation in NP involves a selfsustaining local release of HSP70, ECP, and tryptase, independent of aeroallergen stimulation of the mucosal layer, although the production of these mediators is higher in aeroallergen sensitized NP patients.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Dimić

Perić

Grgurević

et al. 2022

Laryngoscope Investig Oto

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“…14 Another study reported that the IL-5 concentration in nasal secretion increased by fivefold in patients with AR. 15 In studies that used CC16, the CC16 concentration was lower in patients with persistent AR than in healthy individuals, 16 and the CC16 levels in nasal secretions and the severity of rhinitis symptoms negatively correlated. 17 Our results corresponded to those of the previous studies.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Tryptase and CC16/Albumin in Nasal Lavage Fluid as a Screening Tool of Allergic Rhinitis

Kwon

Lee

Park

et al. 2021

Am J Rhinol�Allergy

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Background There is no trial to make a diagnostic tool of allergic rhinitis (AR) utilizing biomarkers from nasal fluid. Base on previous studies, we selected following five biomarkers in nasal fluids that represent the characteristics of allergic reactions: tryptase, eosinophil cationic protein (ECP), interleukin 5 (IL-5), Clara cell protein 16 (CC16) and CC16-to-albumin ratio. Objective This study aimed to identify biomarkers in nasal discharge that may be used in biosensors to diagnose AR as an additional diagnostic tool. Methods Patients showed rhinorrhea and tested positive on allergic skin and specific immunoglobulin E (IgE) tests were included in the AR group. The non-AR group included individuals no dominant nasal symptoms and tested negative on allergy tests. Nasal lavage fluid samples were collected from all participants. Biomarkers in the samples were quantified using enzyme-linked immunosorbent assay. Results Forty-five patients with AR and 28 non-AR subjects were enrolled in this study. Comparing the concentrations of biomarkers, the concentrations of tryptase and IL-5 were significantly higher in the AR group than in the NAR group. And CC16 level and CC16-to-albumin ratio were significantly lower in the AR group. In the combination of tryptase or CC16-to-albumin ratio, the sensitivity was 90.7% and the specificity was 64.3% ( p = 0.013). Conclusion The combination of “tryptase or CC16-to-albumin” could be used as a screening tool for AR. Although this diagnostic method could not replace conventional diagnostic tools, we could consider the method we proposed as an additional screening tool for patients who could not undergo allergy tests.

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“…The relationship between local mucosal production of eosinophilic chemokines and CC16 is very important for the development and further control of chronic inflammation. Previous investigations have demonstrated that eotaxins induce stronger transendothelial migration of eosinophils than of other eosinophilic chemokines (17)(18)(19)(20)(21). Shin et al (22) reported inverse correlation between CC16 and eotaxin-2 in the nasal secretion of PAR subjects.…”

Section: The Role Of Cc16 In Ar and Crsmentioning

confidence: 98%

“…In contrast, CC16 inhibits eosinophil chemoattractant and Th2 cytokine (IL-4, IL-5, IL-13) production (23). In other words, there is a dynamic balance between the local production of eotaxin-2 and CC16, which is disturbed in patients with chronic eosinophilic nasal inflammation (21).…”

Section: The Role Of Cc16 In Ar and Crsmentioning

confidence: 99%

Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants

Perić

Mirković

Vojvodić

2018

Archives of Industrial Hygiene and Toxicology

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Clara cell protein 16 (CC16) is a small protein mainly produced by non-ciliated Clara cells in the respiratory epithelium. It has an anti-inflammatory role in chronic upper and lower airway eosinophilic inflammations. Decreased levels of CC16 are found in the nasal secretions and plasma of patients with chronic eosinophilic inflammatory disorders, such as asthma, allergic rhinitis, and chronic rhinosinusitis with or without nasal polyps, as well as in people exposed to high levels of air pollutants. Intranasal corticosteroid administration suppresses chronic inflammation of the nasal mucosa driven by eosinophils and stimulates local CC16 production. CC16 can be a reliable biomarker of the beneficial effects of perennial allergic rhinitis and chronic rhinosinusitis therapy and of the functional recovery of the nasal mucosa after treatment with topical glucocorticoids.

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Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

Cited by 8 publications

References 26 publications

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Measurement of Tryptase and CC16/Albumin in Nasal Lavage Fluid as a Screening Tool of Allergic Rhinitis

Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants

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