Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Lee, Miryoung; Ebert, James R.; Kadakia, Madhavi; Zhang, Jin; Czerwinski, Stefan A.

doi:10.1002/ajhb.22863

Cited by 16 publications

(13 citation statements)

References 42 publications

(65 reference statements)

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“…Lastly, in a cross-sectional study of children with obesity (n = 209; age 6-19 years) utilizing age, race/ethnicity, season, and BMI adjusted models, the authors reported that total cholesterol, non-HDL cholesterol, and oxidized LDL were inversely associated with log-transformed 25OHD. 21 In this study, the relationship of lipoprotein ratios TG/HDL and TC/HDL with vitamin D status was not assessed.…”

Section: Discussionmentioning

confidence: 97%

Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity

Censani

Hammad

Christos

et al. 2018

Global Pediatric Health

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Adult studies have reported associations of low 25-hydroxyvitamin D (25OHD) with dyslipidemia and cardiovascular disease; however, there are scarce pediatric data regarding relationships between vitamin D status and specific lipid markers affecting cardiovascular risk. In this cross-sectional study of children evaluated at university-based pediatric endocrinology clinics, 178 patients meeting criteria for overweight or obesity had 25OHD levels assessed over a 2-year period; 60 of 178 had non-HDL (high-density lipoprotein) cholesterol and fasting lipid parameters performed. Patients with 25OHD <20 ng/mL had significantly higher non-HDL cholesterol (134.76 ± 47.32 vs 108.85 ± 31.14, P < .03), triglyceride (TG)/HDL ratio (3.09 ± 2.26 vs 1.82 ± 1.18, P = .03), total cholesterol (TC)/HDL ratio (4.23 ± 1.23 vs 3.40 ± 1.05, P < .01), TC (184.15 ± 40.19 vs 158.89 ± 30.10, P < .01), and TG (134.76 ± 47.32 vs 78.93 ± 37.46, P < .03) compared with 25OHD ≥20 ng/mL. Vitamin D deficiency was significantly associated with increase in atherogenic lipids and markers of early cardiovascular disease. These findings suggest that vitamin D deficiency may have negative effects on lipid parameters with increase in cardiovascular risk.

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Section: Discussionmentioning

confidence: 97%

Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity

Censani

Hammad

Christos

et al. 2018

Global Pediatric Health

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Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

“…Many recent studies have investigated the association between vitamin D deficiency and cardiovascular risk factors in overweight and obese children [49][50][51][52][53]. Some studies found a higher prevalence of dyslipidemia in vitamin D deficiency obese subjects compared to subjects with vitamin D sufficiency [50][51][52]. For example, Censani et al [50] found that overweight and obese children with 25OHD deficiency (<20 ng/mL) had significantly higher non-High Density Lipoprotein (HDL) cholesterol (p < 0.03), total cholesterol (TC; p < 0.01), triglycerides (TG; p < 0.03), Low Density Lipoprotein (LDL) levels (p < 0.03), TG/HDL ratio (p = 0.03), and TC/HDL ratio (p < 0.01) than children with 25OHD ≥20 ng/mL.…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

“…No other correlations between TC and non-HDL cholesterol and 25OHD levels were found. Lee et al [52] showed that lipid levels (total cholesterol, non-HDL cholesterol) and oxidized LDL levels were significantly inversely associated with 25OHD concentration in a population of 209 obese American children.…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

“…We must consider that obesity itself is associated to elevated cardiovascular risk factors and metabolic syndrome [47], and that 25OHD deficiency has a very high prevalence in obese subjects [49][50][51][52]. Indeed, obese individuals are sedentary, little exposed to sunlight and with poor diets, leading to lower vitamin D levels.…”

Section: Vitamin D Deficiency and Cardiovascular Risk Factorsmentioning

confidence: 99%

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Vitamin D and Cardiovascular Risk: Which Implications in Children?

Savastio

Pozzi

Tagliaferri

et al. 2020

IJMS

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Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

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Association among 25‐hydroxyvitamin D levels, hypertriglyceridemic‐waist phenotype, and cardiometabolic markers in individuals with type 2 diabetes mellitus from regions with high solar incidence

Oliveira,

Santos,

Santos

et al. 2023

American J Hum Biol

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ObjectiveTo evaluate the relationship between vitamin D status and hypertriglyceridemic‐waist (HTW) phenotype and cardiometabolic markers in individuals with type 2 diabetes mellitus (T2DM) living in regions with high solar incidence (10° south).MethodsAn observational, cross‐sectional study, with 122 individuals with T2DM, of both sexes, aged between 19 and 59 years, residing in Sergipe/Brazil. Measurements included serum 25‐hydroxyvitamin D (25[OH]D), glucose, insulin, total cholesterol, LDL‐c, HDL‐c, triacylglycerols, blood pressure, body mass index, %body fat, and waist circumference. Participants were classified by the presence or absence of the HTW phenotype, according to increased waist circumference and triacylglycerols concentrations. Logistic and linear regression models were applied to verify the association among the concentration of 25(OH)D, HTW phenotype, and lipid profile variables.ResultsTriacylglycerols concentrations (p = .013) and %body fat (p = .011) were higher in women with serum 25(OH)D insufficient/deficient than in those with adequate 25(OH)D levels. Individuals with serum 25(OH)D insufficiency/deficiency were 2.595 times more likely to present the HTW phenotype than those with adequate 25(OH)D levels (p = .021). Additionally, a negative association was observed between the concentration of 25(OH)D and total cholesterol (Beta = −0.204, p = .049).ConclusionInsufficiency/deficiency of serum 25(OH)D in individuals with T2DM increases the chances of developing the HTW phenotype.

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Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Cited by 16 publications

References 42 publications

Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity

Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity

Vitamin D and Cardiovascular Risk: Which Implications in Children?

Association among 25‐hydroxyvitamin D levels, hypertriglyceridemic‐waist phenotype, and cardiometabolic markers in individuals with type 2 diabetes mellitus from regions with high solar incidence

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