Inverse Association between Rheumatoid Arthritis and Contact Allergy

Engkilde, Kåre; Thyssen, Jacob P.; Bangsgaard, Nannie; Menné, Torkil; Johansen, Jeanne Duus

doi:10.2340/00015555-1205

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…In a controlled experimental sensitization study using the strong allergen DPCP, with a sensitization potential stronger than most allergens encountered in the environment, we believe we are the first to show lower sensitization ratios in two groups of psoriasis and diabetes type I patients, respectively, compared with healthy controls. The results support recent epidemiological studies showing an inverse relation between contact allergy and several autoimmune diseases: psoriasis, diabetes type I, inflammatory bowel disease and rheumatoid arthritis [1–4].…”

Section: Discussionsupporting

confidence: 90%

“…Interestingly, recent epidemiological studies have shown that an inverse relation exists between contact allergy and the autoimmune diseases: psoriasis, diabetes type I, rheumatoid arthritis and inflammatory bowel disease [1–4]. Two experimental sensitization studies have shown reduced reactivity to challenge in patients with psoriasis [5,6], but the ability to become sensitized was not investigated.…”

Section: Introductionmentioning

confidence: 99%

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Impaired hapten sensitization in patients with autoimmune disease

Bangsgaard¹,

Engkilde

Menné³

et al. 2011

Clinical and Experimental Immunology

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SummaryAn inverse relation between contact allergy and autoimmune diseases is suggested from epidemiological studies. The aim of this study was to investigate susceptibility and reactivity in patients with psoriasis, patients with diabetes and healthy controls in an experimental sensitization study. We sensitized 68 adult individuals (23 patients with psoriasis, 22 patients with diabetes and 23 healthy controls) with diphenylcyclopropenone (DPCP) and assessed challenge responses with visual scoring and ultrasound. Skin biopsies from challenged skin were investigated for differences in down-regulatory mechanisms with immunohistochemistry and gene-expression profiles using microarray technology. The sensitization ratios were 26%, 36% and 65% for the psoriatic, diabetic and healthy groups, respectively. Logistic regression analysis gave an odds ratio (OR) for a patient with psoriasis or diabetes type I of being sensitized to 0·18 [95% confidence interval (CI): 0·039-0·85], P = 0·031 and 0·74 (95% CI: 0·548-1·008), P = 0·056, respectively. A high degree of forkhead box P3-positive (FoxP3 + ) cells were found in biopsies of positively challenged reactions, but only limited numbers in negatively challenged reactions, with no difference among the groups. No specific mRNA expression was found in the challenged skin of negative elicitation reactions, also indicating no sign of active down-regulation. The study contibutes strongly to the evidence of a decreased susceptibility to develop contact allergy in individuals with autoimmune diseases such as psoriasis.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Impaired hapten sensitization in patients with autoimmune disease

Bangsgaard¹,

Engkilde

Menné³

et al. 2011

Clinical and Experimental Immunology

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“…A greater severity disease is inevitably correlated to higher inflammatory state that in psoriasis we have seen to be pro‐osteoclastogenic. Conversely, we have demonstrated that cutaneous inflammation involved in ACD doesn't promote OCP differentiation, rather it has been reported an inverse association between ACD and rheumatoid arthritis which, like PsA, is characterized by bone damage . These evidences suggest a unique property of pro‐osteoclastogenic inflammation underlying the psoriatic plaque.…”

Section: Discussionmentioning

confidence: 66%

Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage

et al. 2017

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Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy that can be associated with focal bone erosions. Psoriasis usually precedes the psoriatic arthritis onset by an average of 10 years, but this relation is not yet fully elucidated. Pro-inflammatory cytokines, such as IL-33, OPN, IL-17, and TNF-α are involved in both psoriasis and PsA pathogenesis as well as in bone homeostasis. In this study, we have demonstrated that IL-33, OPN, IL-17, and TNF-α induced the release of a wide range of pro-osteoclastogenic factors from the skin, such as RANKL, that promote monocyte differentiation in osteoclasts. The addition of osteoprotegerin, a RANKL inhibitor, to monocyte cultures treated with supernatant from stimulated skin did not completely deplete osteoclast formation, suggesting that skin produced several additional pro-osteoclastogenic mediators, which could act in a RANKL-independent manner. Moreover, we have found that RANKL serum levels as well as osteoclast number and activity in psoriatic patients with and without arthritis, was influenced by severity of cutaneous disease. Our data demonstrate that psoriatic cutaneous inflammation contributes to bone damage.

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“…Also, although we observed an increased risk of certain autoimmune diseases in patients with rosacea, it is important to note that T1DM and rheumatoid arthritis in these registers appear to be inversely associated with other common skin conditions such as contact dermatitis and atopic dermatitis, which makes detection bias caused by increased health care consumption less likely. [41][42][43] Lastly, the Danish population is predominantly of Caucasian descent, and therefore extrapolation of results to patients of other ethnicities should be carried out with caution.…”

Section: J Am Acad Dermatolmentioning

confidence: 99%