Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria

Gbolade, A. A.

doi:10.1016/j.jep.2008.10.013

Cited by 147 publications

(55 citation statements)

References 16 publications

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“…Consensuses have emerged that identifying the potential plants that can produce such antidiabetic properties must be primary to this goal (Bailey & Day 1989, Ghourri et al 2013. Accordingly, studies have documented the diversity and use of antidiabetic plants by indigenous communities in Asia (Chhetri et al 2005, Grover et al 2002, Kadir et al 2012, Ocvirk et al 2013, Tag et al 2012 and Africa societies (Gbolade 2009, Ghourri et al 2013, Semenya et al 2012a. From these studies, it appeared that people's knowledge about plant and medicinal potentials may vary, even at smaller scales.…”

Section: Ethnobotany Research and Applications 232mentioning

confidence: 99%

Diversity, Knowledge, and Use of Plants in Traditional Treatment of Diabetes in the Republic of Benin

Laleye¹,

Mensah

Assogbadjo

et al. 2015

Ethnobot. Res. App.

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Section: Ethnobotany Research and Applications 232mentioning

confidence: 99%

Diversity, Knowledge, and Use of Plants in Traditional Treatment of Diabetes in the Republic of Benin

Laleye¹,

Mensah

Assogbadjo

et al. 2015

Ethnobot. Res. App.

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“…Aloe spp. is documented in ethnobotanical survey as one of the potential anti-diabetic plants (Gbolade, 2009). The dried sap, of the Aloe plant had been used for diabetes in the Arabian Peninsula .…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Many of the health benefits associated withPolysaccharides from the plants were isolated using hot extraction method and then hydrolyzed. The polysaccharide hydrolysates were identified using high performance liquid chromatographic technique. Maximum yield of total polysaccharides identified were obtained from A 7 (12.04%), A 1 (8.51%), A 8 (8.03%), A 2 (5.32%) and A 6 (2.18%) respectively. The isolated polysaccharides were tested for antihyperglycemic activity in alloxan-induced diabetic rats and alpha glucosidase inhibitory activity. Chromatographic investigation of the polysaccharides recorded the presence of 18 saccharides, glucuronic acid, stachyose, galacturonic acid, sucrose, glucose, xylose, galactose, rhamnose, mannose, arabinose, fructose polyol, mannitol and sorbitol in the eight Aloe species, but their quantitative composition differed among the species. Glucuronic acid, stachyose and galacturonic acid were the major detected saccharides. The results of the biological activities revealed significant antihyperglycemic activities with variable degrees. After four weeks of daily administration, polysaccharides isolated from A. vera (A 1 ) and A. arborescens (A 2 ) were the most active with 40 and 44% reduction in blood glucose level, respectively. All the tested polysaccharides showed significant alpha glucosidase inhibitory activity with IC50 (µg/ml) 11.70, 14.60 and 15.80 for A 7 , A 6 and A 1 respectively. In conclusion, the tested polysaccharides contribute to the antidiabetic action of these Aloe species.

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“…This information often directs clinical and pharmacological studies and also the isolation of substances responsible for therapeutic effi cacy (Albuquerque & Andrade, 2002;Gbolade, 2009).…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria

Cited by 147 publications

References 16 publications

Diversity, Knowledge, and Use of Plants in Traditional Treatment of Diabetes in the Republic of Benin

Diversity, Knowledge, and Use of Plants in Traditional Treatment of Diabetes in the Republic of Benin

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Anti-ulcer activity of Synadenium grantii latex

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