Inventions and Innovations in Preclinical Platforms for Cancer Research

Abstract

Three-dimensional (3D) cell culture systems can be regarded as suitable platforms to 11 bridge the huge gap between animal studies and two-dimensional (2D) monolayer cell culture to 12 study chronic diseases such as cancer. In particular, the preclinical platforms for multicellular

Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models

“…18,19 In comparison with other 3D cell culture approaches, MTs are more straightforward to generate, more uniform, and less expensive. [20][21][22] The previous device could be operated without the need for a pump and relied on gravity-driven perfusion. The flow speed could be modulated by adjusting the tilting angle.…”

Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

“…Alternatively, microfluidic technology can address the limitations associated with conventional ISF sampling techniques. Microfluidics is an emerging science and technology that can offer significant improvements over various fields, including surface science [15], nanotechnology for disease diagnosis [16], mixing [17] and separation [18,19], mechanobiology [20], cancer research [21,22], cell culture [23,24], single-cell analysis [25], drug delivery at cellular [26] and tissue levels [27], electrochemical biosensing [28], and POC sensing [29]. Furthermore, the emerging field of micro elastofluidics can provide microfluidic solutions for flexible, conformal system attached to the skin [26].…”

A tool for designing tree-like concentration gradient generators for lab-on-a-chip applications

“…Microfluidic CGGs have emerged as essential components in most cell culture and organ-ona-chip platforms (Kashaninejad et al, 2016;Moshksayan et al, 2018a;Moshksayan et al, 2018b).…”