Invasome: A Novel Nanocarrier for Transdermal Drug Delivery

Babaie, Soraya; Bakhshayesh, Azizeh Rahmani Del; Ha, Ji Won; Hamishehkar, Hamed; Kim, Ki‐Hyun

doi:10.3390/nano10020341

Cited by 86 publications

(64 citation statements)

References 69 publications

(78 reference statements)

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“…In vitro tests showed a sustained release of methotrexate from the nanocarriers, whereas permeation studies demonstrated enhanced skin penetration of methotrexate after incorporation into SLNs. Photosensitive nanoformulations are also applied in acne treatment, a common inflammatory skin condition that can cause discomfort and visible, long-lasting scarring [127]. Examples of treatment agents for acne lesions are retinoids, such as tretinoin, efficiently encapsulated in liposomes [102] and nanoemulsions [110].…”

Section: Advances In Skin Formulationsmentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

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Section: Advances In Skin Formulationsmentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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“…In addition to providing an increased bioavailability and a more controlled drug release, our approach may also facilitate topical administration of thymol-invasomes due to the high permeability rate of invasomes through the skin [2,21,24].…”

Section: Succsessfull Preparation Of Invasomes Encapsulating the Terpmentioning

confidence: 99%

“…The application of soy lecithin liposomes comprising cinnamon oil was further shown to improve stability of the essential oil and extend the bactericidal action time [20]. In addition, the application of invasomes was particularly found to elevate the stability of the encapsulated compounds (reviewed in [24]).…”

Section: Growth-inhibition Zone Assay Shows Strong Bactericidal Activmentioning

confidence: 99%

“…In addition to nanostructured lipid carriers, terpenoids can also be delivered by encapsulation into polymeric nanostructured systems or by molecular complexation [2]. In addition to increasing stability of encapsulated compounds, terpenoid-encapsulation systems are widely accepted to be non-cytotoxic and enhance the antioxidant and anti-inflammatory activities of terpenoids ( [18,[21][22][23] reviewed in [2,24]). For instance, Manconi and colleagues reported the liposomal formulation of thymus essential oil to be highly biocompatible and to counteract oxidative stress in keratinocytes [22].…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Terpenoid-Invasomes with Selective Activity against S. aureus and Characterization by Cryo Transmission Electron Microscopy

et al. 2020

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Terpenoids are natural plant-derived products that are applied to treat a broad range of human diseases, such as airway infections and inflammation. However, pharmaceutical applications of terpenoids against bacterial infection remain challenging due to their poor water solubility. Here, we produce invasomes encapsulating thymol, menthol, camphor and 1,8-cineol, characterize them via cryo transmission electron microscopy and assess their bactericidal properties. While control- and cineol-invasomes are similarly distributed between unilamellar and bilamellar vesicles, a shift towards unilamellar invasomes is observable after encapsulation of thymol, menthol or camphor. Thymol- and camphor-invasomes show a size reduction, whereas menthol-invasomes are enlarged and cineol-invasomes remain unchanged compared to control. While thymol-invasomes lead to the strongest growth inhibition of S. aureus, camphor- or cineol-invasomes mediate cell death and S. aureus growth is not affected by menthol-invasomes. Flow cytometric analysis validate that invasomes comprising thymol are highly bactericidal to S. aureus. Notably, treatment with thymol-invasomes does not affect survival of Gram-negative E. coli. In summary, we successfully produce terpenoid-invasomes and demonstrate that particularly thymol-invasomes show a strong selective activity against Gram-positive bacteria. Our findings provide a promising approach to increase the bioavailability of terpenoid-based drugs and may be directly applicable for treating severe bacterial infections such as methicillin-resistant S. aureus.

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“…A new phospholipid vesicle, invasome, has been presented as a system able to improve the permeation through the skin, thus decreasing absorption into the systemic circulation. 73 This innovative carrier is composed of phosphatidylcholine and terpenes that synergistically act with ethanol in disrupting the ordered structure of the stratum corneum to enhance the percutaneous permeation of the drug and to make phospholipid structures flexible. El-Nabarawi et al prepared dapsone-loaded invasomes for acne treatment, using different concentrations of various terpenes (limonene, cineole, fenchone and citral).…”

mentioning

confidence: 99%

<p>The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity</p>

Mancuso¹,

Cristiano²,

Fresta³

et al. 2020

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Invasome: A Novel Nanocarrier for Transdermal Drug Delivery

Cited by 86 publications

References 69 publications

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

Preparation of Terpenoid-Invasomes with Selective Activity against S. aureus and Characterization by Cryo Transmission Electron Microscopy

<p>The Challenge of Nanovesicles for Selective Topical Delivery for Acne Treatment: Enhancing Absorption Whilst Avoiding Toxicity</p>

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