Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study

Berry, Geoffrey; MacLennan, Robert; Shearman, Rodney P.; Jelihovsky, Tatiana; Booth, J. Cooper; Molina, Ramiro; Martinez, L.; Salas, O; Dabancens, Alfredo; Chen, Zhiheng; Yun, Tae-Jin; Wei, Hu; Cuadros, Alvaro; Aristizabal, Nubia; Modan, Baruch; Ron, Elaine; Alfandary, Esther; Mati, J. G.; Kenya, Patrick; Kung'u, A; Gatei, D.; Cuevas, Héctor Rodriguez; Salazar, Socorro Benavides; Palet, A.; Ontiveros, Patricia; Ibeziako, Pat A.; Junaid, T.A.; Aghediuno, P.; Abioye, A. A.; Apelo, R; Cruz, J. R. de la; Baens, J.; Canlas, Benjamin D.; Silpisornkosol, Suporn; Pardthaisong, Tieng; Charoeniam, Viruch; Theetranont, Choti; Boosiri, Banpot; Chutivongse, Supawat; Virutamasen, Pramuan; Wongsrichanalai, Chansuda; Sindhavananda, Sermsri; Koetsawang, Suporn; Rachawat, Daungdao; Koetsawang, Amorn; Riotton, G.; Christopherson, William M.; Melnick, Joseph L.; Adam, Ervín; Thomas, David B.; Ray, Roberta M.; Noonan, Elizabeth A.; Stanford, Janet L.; Rosenblatt, Karin A.; Holck, S; Meirik, Olav; Farley, Timothy M.M.

doi:10.1002/ijc.2910550211

Cited by 56 publications

(5 citation statements)

References 28 publications

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“…The contraceptive depo-medroxyprogesterone (DMPA) is an injectable form of progestin that is given every 3 months for pregnancy protection in humans. DMPA and spermicide such as N-9 have been reported to change the genital tract microenvironment and cause the vagina and cervix to be more susceptible to viral infection and persistence [ 48 , 49 , 50 , 51 ]. Vaginal epithelial cells of mature female mice responded to changing levels of estrogens and progesterone during a 4–5-day estrous cycle.…”

Section: Discussionmentioning

confidence: 99%

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Brendle

et al. 2022

Viruses

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Contraceptives such as Depo-medroxyprogesterone (DMPA) are used by an estimated 34 million women worldwide. DMPA has been associated with increased risk of several viral infections including Herpes simplex virus-2 (HSV-2) and Human immunodeficiency virus (HIV). In the current study, we used the mouse papillomavirus (MmuPV1) anogenital infection model to test two hypotheses: (1) contraceptives such as DMPA increase the susceptibility of the anogenital tract to viral infection and (2) long-term contraceptive administration induces more advanced disease at the anogenital tract. DMPA treatments of both athymic nude mice and heterozygous NU/J (Foxn1nu/+) but ovariectomized mice led to a significantly increased viral load at the anogenital tract, suggesting that endogenous sex hormones were involved in increased viral susceptibility by DMPA treatment. Consistent with previous reports, DMPA treatment suppressed host anti-viral activities at the lower genital tract. To test the impact of long-term contraceptive treatment on the MmuPV1-infected lower genital tract, we included two other treatments in addition to DMPA: 17β-estradiol and a non-hormone based contraceptive Cilostazol (CLZ, Pletal). Viral infections were monitored monthly up to nine months post infection by qPCR. The infected vaginal and anal tissues were harvested and further examined by histological, virological, and immunological analyses. Surprisingly, we did not detect a significantly higher grade of histology in animals in the long-term DMPA and 17β-estradiol treated groups when compared to the control groups in the athymic mice we tested. Therefore, although DMPA promotes initial papillomavirus infections in the lower genital tract, the chronic administration of DMPA does not promote cancer development in the infected tissues in our mouse model.

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Section: Discussionmentioning

confidence: 99%

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Brendle

et al. 2022

Viruses

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“…The possible association between the use of OCP and the development of cervical neoplasia has been the subject of many epidemiological investigations, but the nature of the association remains unclear [9]. In 1993 a massive worldwide study conducted by the World Health Organization, was published which examined the risk established between OCP use and invasive squamous cervical carcinoma among 2300 women who had cervical carcinoma and found a strong correlation [10]. In a large study group, Herrero et al showed that women who had received injectable progestins for at least 5 years and who had used them at least 5 years ago suffered a 430% increased risk of developing cervical cancer [11].…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with precancerous cervical lesion among women screened at Marie Stops Ethiopia, Adama town, Ethiopia 2017: a case control study

Kassa

2018

BMC Res Notes

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ObjectiveAlthough cervical cancer is a preventable disease, it remains a leading cause of death among women in developing countries. In this unmatched case control design, 55 cases and 109 controls were included. The main objective of this study was to assess the risk factors of precancerous cervical lesion in Adama town.ResultsA total of 164 participants were recruited in this study. Of the 109 controls, 64 (61%) and 41 (39%) of cases were using oral contraception. Women who were using oral contraception were two times at risk for developing precancerous cervical lesion than who were not using (COR = 2.059 95% CI 1.006, 4.216; AOR = 2.342). Out of 55 cases, 21 (38.2%) cases had a history STI and out of 109 controls, 24 (22.2%) controls had a history of STI. It was revealed that STI has a significant association for developing of precancerous lesion. Women who had a history of STI were two times at risk of developing precancerous cervical lesion than who had no (COR = 2.187; AOR = 2.485). It was found that initiation of sexual intercourse before the age of 15 years has 5.6 risks to develop precancerous cervical lesion (COR = 5.625 AOR = 6.703).Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3244-6) contains supplementary material, which is available to authorized users.

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“…Human papillomavirus 16, the most important cause of cervical cancer, contains a progesterone/glucocorticoid response element upstream to the common E6/E7 promoter,14 and progesterone enhances the ability of the viral DNA to transform cells 15. In fact, papillomavirus lesions are exacerbated during pregnancy16 and risk of cervical cancer is increased by oral contraceptives and pregnancy when progestogen levels are high 1 3 4 17. Oestrogen increases human papillomavirus expression by upregulation of the progesterone receptor 18.…”

Section: Discussionmentioning

confidence: 99%

Case-control study of oestrogen replacement therapy and risk of cervical cancer

Parazzini

Vecchia

Negri

et al. 1997

BMJ

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Objective: To examine any possible links between exposure to DDE (1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene), the persistent metabolite of the pesticide dicophane (DDT), and breast cancer. Design: Multicentre study of exposure to DDE by measurement of adipose tissue aspirated from the buttocks. Laboratory measurements were conducted in a single laboratory. Additional data on risk factors for breast cancer were obtained by standard questionnaires. Setting: Centres in Germany, the Netherlands, Northern Ireland, Switzerland, and Spain. Subjects: 265 postmenopausal women with breast cancer and 341 controls matched for age and centre. Main outcome measure: Adipose DDE concentrations. Results: Women with breast cancer had adipose DDE concentrations 9.2% lower than control women. No increased risk of breast cancer was found at higher concentrations. The odds ratio of breast cancer, adjusted for age and centre, for the highest versus the lowest fourth of DDE distribution was 0.73 (95% confidence interval 0.44 to 1.21) and decreased to 0.48 (0.25 to 0.95; P for trend = 0.02) after adjustment for body mass index, age at first birth, and current alcohol drinking. Adjustment for other risk factors did not materially affect these estimates. Conclusions: The lower DDE concentrations observed among the women with breast cancer may be secondary to disease inception. This study does not support the hypothesis that DDE increases risk of breast cancer in postmenopausal women in Europe.

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Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study

Cited by 56 publications

References 28 publications

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model

Risk factors associated with precancerous cervical lesion among women screened at Marie Stops Ethiopia, Adama town, Ethiopia 2017: a case control study

Case-control study of oestrogen replacement therapy and risk of cervical cancer

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