Invasive recurrence of serous borderline ovarian tumor as multifocal lymphadenopathy 25years after initial diagnosis

Alagkiozidis, Ioannis; Dorcelus, Sandy; Somma, Jonathan; Chun, L. Y.; Salame, Ghadir

doi:10.1016/j.gynor.2012.08.002

Cited by 3 publications

(4 citation statements)

References 9 publications

(15 reference statements)

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“…A characteristic feature of mucinous ovarian tumor is the presence of a morphological continuum with benign, borderline and malignant lesions occurring simultaneously. This tumor heterogeneity is thought to reflect the nature of its biological progression . Ovarian IECA, which is the equivalence of an ovarian precancerous lesion or an ovarian carcinoma in situ, is thought to be a transitional stage in the process of malignant transformation from MBOTs to mucinous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor heterogeneity is thought to reflect the nature of its biological progression. 9,10 Ovarian IECA, which is the equivalence of an ovarian precancerous lesion or an ovarian carcinoma in situ, is thought to be a transitional stage in the process of malignant transformation from MBOTs to mucinous carcinoma. However, the clinical prognoses of these diseases are greatly different.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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Aim To investigate the clinicopathologic characteristic and fertility results of patients with mucinous borderline ovarian tumors (MBOTs), and the effects of intraepithelial carcinoma (IECA) on them. Methods Fifty‐two patients treated for MBOTs with or without IECA were retrospectively analyzed. Results Patients with IECA were more frequently observed at stage Ic (3/12 vs 1/40, P = 0.034) and accompanied by microinvasive carcinoma (3/12 vs 1/40, P = 0.034). The detected rate of IECA by intraoperative frozen section (5/12, 41.7%) was much lower than that of MBOTs (82.5%, P = 0.010). About 61.5% patients in our study underwent fertility‐sparing surgery. Follow‐up information was retained completely in 41 patients. And all four tumor recurrences were observed (9.8%) in conservative surgery group in 66 months, though there was no statistical association (P = 0.280). There were three patients who recurred more than once, even one occurred tumor‐related death. Only one recurrent patient was in IECA group (P > 0.05). However, patients with IECA were more likely to receive adjuvant chemotherapy (3 of 12 vs 0 of 40, P = 0.010) and surgical staging (75% vs 52.5%, P = 0.200). As for fertility results, nine patients wished to be pregnant and seven of them (77.8%) were successful. Conclusion For young patients with MBOTs, fertility results are satisfactory after conservative surgery. But patients should be fully informed about the relative high recurrent rate. And IECA has no statistical negative effects on MBOTs till now, but a long‐term follow‐up is required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Chen

Tao

et al. 2020

J of Obstet and Gynaecol

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“…Serous borderline/atypical proliferative serous tumour (SBT/APST) can present at a high stage, with nodal metastasis and a low risk of transformation to low‐grade serous carcinoma (LGSC) . Histological features of nodal involvement by LGSC and/or its precursor SBT/APST have been described, but literature on the cytological features is sparse. One case report briefly illustrates recurrent SBT/APST as multifocal lymphadenopathy but does not describe the cytomorphology in detail .…”

Section: Introductionmentioning

confidence: 99%

“…Histological features of nodal involvement by LGSC and/or its precursor SBT/APST have been described, but literature on the cytological features is sparse. One case report briefly illustrates recurrent SBT/APST as multifocal lymphadenopathy but does not describe the cytomorphology in detail . With cyto‐histological correlation, we illustrate a case of nodal low‐grade serous pelvic neoplasia, highlighting previously undescribed cytomorphological features, which may give clues to the diagnosis, thereby raising awareness of these rare nodal lesions…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration cytology of a nodal low‐grade serous neoplasm: a case report of low‐grade serous carcinoma arising from a serous borderline tumour with cyto‐histological correlation

2016

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Lymph Node Involvement in Recurrent Serous Borderline Ovarian Tumors: Current Evidence, Controversies, and a Review of the Literature

Wetterwald

Sarivalasis

Liapi

et al. 2023

Cancers

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Borderline ovarian tumors (BOTs) account for 10–20% of epithelial ovarian neoplasms. They are characterized by their lack of destructive stromal invasion. In comparison to invasive ovarian cancers, BOTs occur in younger patients and have better outcome. Serous borderline ovarian tumor (SBOT) represents the most common subtype of BOT. Complete surgical staging is the current standard management but fertility-sparing surgery is an option for SBOT patients who are at reproductive age. While most cases of SBOTs have an indolent course with favorable prognosis, late recurrence and malignant transformation can occur, usually in the form of low-grade serous carcinoma (LGSC). Thus, assessment of the recurrence risk is essential for the management of those patients. SBOTs can be associated with lymph node involvement (LNI) in up to 30% of patients who undergo lymph node dissection at diagnosis, and whether LNI affects prognosis is controversial. The present review suggests that recurrent SBOTs with LNI have poorer oncological outcomes and highlights the biases due to the scarcity of reports in the literature. Preventing SBOTs from recurring and becoming invasive overtime and a more profound understanding of the underlying mechanisms at play are necessary.

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Invasive recurrence of serous borderline ovarian tumor as multifocal lymphadenopathy 25years after initial diagnosis

Cited by 3 publications

References 9 publications

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Mucinous borderline ovarian tumors with and without Intraepithelial Carcinoma: Differences in clinicopathologic features and fertility results

Fine needle aspiration cytology of a nodal low‐grade serous neoplasm: a case report of low‐grade serous carcinoma arising from a serous borderline tumour with cyto‐histological correlation

Lymph Node Involvement in Recurrent Serous Borderline Ovarian Tumors: Current Evidence, Controversies, and a Review of the Literature

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