Fine needle aspiration cytology of a nodal low‐grade serous neoplasm: a case report of low‐grade serous carcinoma arising from a serous borderline tumour with cyto‐histological correlation

Razack, Rubina; Merwe, Hanneli Van der; Schubert, Pawel

doi:10.1111/cyt.12354

Cited by 3 publications

(3 citation statements)

References 13 publications

(20 reference statements)

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“…A few previous reports have briefly described cytological findings in LGSC, but none have provided detailed descriptions 8–10 . Our cytological examination of LGSC revealed isolated atypical epithelial cells and variable cellular clusters of sheet‐like, tubular, papillary, and micropapillary structures.…”

Section: Discussionmentioning

confidence: 71%

“…3 A few previous reports have briefly described cytological findings in LGSC, but none have provided detailed descriptions. [8][9][10] Our cytological examination of LGSC revealed isolated atypical epithelial cells and variable cellular clusters of sheet-like, tubular, papillary, and micropapillary structures. LGSC cells are usually small-to-mediumsized and have a high nuclear-to-cytoplasmic content ratio, nuclei with small irregularities, increased coarse chromatin, and prominent nucleoli.…”

Section: Discussionmentioning

confidence: 99%

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Low‐grade serous carcinoma detected from intraoperative peritoneal washings: Cytological findings and detection of KRAS mutation

Yamamoto

Warigaya²,

Kinoshita

et al. 2022

Cancer Reports

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Background Low‐grade serous carcinoma (LGSC) of the ovary, which is extremely rare tumor, has better prognosis than high‐grade serous carcinoma (HGSC). Genetic backgrounds of those are different, so that LGSC usually shows KRAS or BRAF mutation, whereas HGSC does not show such mutations. Since treatment strategies of those are different, differential pathological diagnosis between LGSC and HGSC is very important. Case We report a case of LGSC that was diagnosed by both cytological findings and genetic analysis using small amount cells from cytological specimen. The 30‐year‐old Japanese woman with bilateral ovarian tumors underwent salpingo‐oopherectomy. The peritoneal washing cytologic specimen and touched cytologic specimen from the tumor included non‐complex clusters with psammoma bodies composed of tumor cells with mild to moderate atypia and without bizarre nuclei. The ovarian tumor was histologically diagnosed as LGSC. The genetic analysis that was done using exfoliated cells from peritoneal washings specimen by idensy™, detected KRAS mutation at codon 12/13. Conclusion The genetic investigation using cytological specimen as well as characteristic cytological findings were useful to make differential diagnosis between LGSC and HGSC.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Low‐grade serous carcinoma detected from intraoperative peritoneal washings: Cytological findings and detection of KRAS mutation

Yamamoto

Warigaya²,

Kinoshita

et al. 2022

Cancer Reports

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show abstract

“…2d). Therefore, such findings should be reported as a "low-grade serous neoplasm" rather than a low-grade serous carcinoma [21,22]. To support one's diagnosis, immunohistochemistry for claudin-4 (positive in epithelial tumors), PAX-8, ER, and progesterone receptor (PR) (positive in tumors of Mullerian origin), WT-1 (typically diffusely positive in these tumors of serous lineage), in addition to p53 and p16, can be employed [11,13,17].…”

Section: Differential Diagnosismentioning

confidence: 99%

Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors

Goyal¹

2023

Acta Cytologica

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Background: The tumors involving the gynecologic tract encompass a wide range of lesions including those of epithelial, mesenchymal, sex cord-stromal, and germ cell origin. Amongst the carcinomas of tubo-ovarian origin, high-grade serous carcinoma is the most common malignancy. The primary role of fine needle aspiration (FNA) cytology in the management of gynecologic tract malignancies is in the diagnosis of their recurrences/metastases. In patients presenting with advanced disease, the cytology specimen may be the initial or the only sampling performed before the initiation of treatment. Summary: This review will discuss the cytologic findings of various gynecologic tract neoplasms with regard to their morphologic features, differential diagnoses, and the ancillary studies that can assist in their recognition. Key Messages: FNA cytology serves as a valuable tool in the diagnosis and management of gynecologic tract malignancies. However, making an accurate diagnosis of these entities, especially on limited cytology specimens, can be challenging. Awareness regarding the morphologic spectrum of these tumors, their potential mimics, and the ancillary studies that can be employed to refine their characterization, can assist in arriving at the correct diagnosis.

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Special Considerations for Peritoneal Washings

VandenBussche

Crothers

Fader

et al. 2020

The International System for Serous Fluid Cytopathology

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Fine needle aspiration cytology of a nodal low‐grade serous neoplasm: a case report of low‐grade serous carcinoma arising from a serous borderline tumour with cyto‐histological correlation

Abstract: This case report describes a rare case of nodal low grade serous pelvic neoplasia. Together with histological correlation, it illustrates previously undocumented cytomorphological features and also discusses important differential diagnosis and potential pitfalls for misdiagnosis.

Cited by 3 publications

References 13 publications

Low‐grade serous carcinoma detected from intraoperative peritoneal washings: Cytological findings and detection of KRAS mutation

Low‐grade serous carcinoma detected from intraoperative peritoneal washings: Cytological findings and detection of KRAS mutation

Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors

Special Considerations for Peritoneal Washings

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