Invasive Prenatal Diagnosis: Amniocentesis

Abstract

In this article, we will review the history and the evolution of the technique of amniocentesis and the indications of the most common invasive diagnostic and therapeutic procedure. Moreover, the most common complications of amniocentesis will be presented. Finally, we will try to establish if the use of con current ultrasound had any effect on the prevalence on these complications.

Cytomegalovirus Infection in Pregnancy Prevention and Treatment Options: A Systematic Review and Meta-Analysis

“…Amniocentesis is a method to withdraw amniotic fluid from the uterine cavity through a trans-abdominal approach using a needle [39]. Specifically, it is an invasive approach for the prenatal diagnosis of several pregnancyrelated conditions [40]. The procedure can be done from at least 6-8 weeks post proven seroconversion or within 20-21 weeks of pregnancy otherwise.…”

“…In contrast, in another cohort study, Minsart et al administered CMV-specific HIG to16 women for suspected CMV during pregnancy while 55 mothers did not have any specific treatment and used bivariate analysis to show that HIG treatment did not considerably lower CMV or post-natal infections in the considerable treatment and prophylactic groups [29]. In contrast, a cohort study by Blazquez-Gamero et al examined mother-infant pairs with a median gestation birth age of 39 weeks (interquartile range: [38][39][40] and two premature cases. Of 30 cases using amniocentesis, 21 fetuses showed a CMV PCR positive status (70%), one fetus with positive PCR results was injected an HIG dose and presented with CMV-PCR negative status showing no symptoms at 12 months.…”