Invasive Pneumococcal Infections Among Hospitalized Children in Bamako, Mali

Abstract

IPD is common and frequently fatal among hospitalized children in Mali, but surprisingly little resistance has occurred. Notably, 91% of the serotypes causing IPD in Bamako children are found in the 11-valent pneumococcal conjugate vaccine.

Genotypic Analysis of Invasive Streptococcus pneumoniae from Mali, Africa, by Semiautomated Repetitive-Element PCR and Pulsed-Field Gel Electrophoresis

“…In Mali, West Africa, children have limited access to health care and are not immunized against S. pneumoniae. Although the rates in Mali were not unlike those in other developing countries, the rates of IPD in hospitalized children in Mali were reported to be higher than those of industrialized nations (3). Furthermore, the case fatality rate due to IPD in hospitalized children in Mali was 23.6%.…”

“…Streptococcus pneumoniae is the most common cause of bacterial pneumonia in children in developing countries (3,14). Invasive pneumococcal disease (IPD) is also a major cause of morbidity and mortality, particularly in the developing world.…”

Sickle cell disease as a paradigm of immigration hematology: new challenges for hematologists in Europe

“…51,59 Differences in prevalence of the common infective organisms in patients with sickle cell disease between African and European countries, for example, are crucial to identify since this will dictate the effectiveness of prophylactic measures. Penicillin prophylaxis has played a major role in reducing mortality in developed countries 60 and it is important to find out whether it will be similarly beneficial in African countries where several groups have found that Streptococcus pneumoniae is also a major cause of morbidity and mortality 61,62 whereas others report that it is less common. 63 The growth of research collaborations in sickle cell disease between developing countries and well resourced countries 31,32,[61][62][63] has recently been highlighted as an important tool for improving clinical and diagnostic facilities in developing countries as well as advancing our knowledge of disease pathogenesis.…”

PCR Method To Identify Salmonella enterica Serovars Typhi, Paratyphi A, and Paratyphi B among Salmonella Isolates from the Blood of Patients with Clinical Enteric Fever

“…One set included 443 isolates obtained from blood cultures of 431 febrile patients at l'Hôpital Gabriel Touré in Bamako, Mali, in the course of systematic surveillance for bacteremia and invasive bacterial disease among patients younger than 16 years of age with fever, who were admitted to the hospital or seen in the emergency room (6,27). Strains initially identified in the clinical microbiology laboratory of the Centre pour le Développement des Vaccins, Bamako, Mali (CVD-Mali), as Salmonella serotype Typhi, Paratyphi A, or Paratyphi B or as Salmonella species were shipped to CVD-Baltimore for bacteriological confirmation.…”