Invasive pneumococcal disease in children with cancer: Incidence density, risk factors and isolated serotypes

Lages, Pedro Mendes; Carlesse, Fabianne; Boettger, Bruno Cruz; Pignatari, Antônio Carlos Campos; Petrilli, Antônio Sérgio; Moraes-Pinto, Maria Isabel de

doi:10.1016/j.bjid.2020.09.003

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…From 51 episodes of IPD recorded there, majority of them (52.9%) presented with occult bacteremia. 12 These findings were consistent with our cases, with our first patient presented with febrile neutropenia, and our second patient had occult bacteremia.…”

Section: Discussionsupporting

confidence: 93%

Pediatric Invasive Pneumococcal Disease (IPD) in Yogyakarta, Indonesia: A Case Series

Arguni

Wijaya

Indrawanti

et al. 2022

Global Pediatric Health

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Given the fact that invasive pneumococcal disease (IPD) has a high clinical burden, particularly among children in developing countries, data on its occurrence and clinical profile in Indonesia is still insufficient. We presented 3 cases of IPD in children who were admitted to Dr. Sardjito General Hospital, Yogyakarta, Indonesia between 2016 and 2019. While our first 2 patients had milder course of disease, our third patient who presented with meningoencephalitis had poor outcome. Risk factors shown in our cases were young age and malignancy history. Multiple antibiotic resistance was observed in our isolates. The fact that none of our patients have received pneumococcal vaccination marks the necessity of this vaccine especially for at-risk children.

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Section: Discussionsupporting

confidence: 93%

Pediatric Invasive Pneumococcal Disease (IPD) in Yogyakarta, Indonesia: A Case Series

Arguni

Wijaya

Indrawanti

et al. 2022

Global Pediatric Health

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“… 9 , 20 Thus, limited data are available on the clinical characteristics of hospitalized patients with IPD. 21 , 22 …”

Section: Introductionmentioning

confidence: 99%

Chronic medical conditions associated with invasive pneumococcal diseases in inpatients in teaching hospitals in São Paulo city: Estimating antimicrobial susceptibility and serotype-coverage of pneumococcal vaccines

Kfouri¹,

Brandileone

Sáfadi

et al. 2023

The Brazilian Journal of Infectious Diseases

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Invasive pneumococcal disease in Latin America and the Caribbean: Serotype distribution, disease burden, and impact of vaccination. A systematic review and meta-analysis

Bardach,

Ruvinsky,

Palermo

et al. 2024

PLoS ONE

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Background Invasive pneumococcal diseases (IPD) are associated with high morbidity, mortality, and health costs worldwide, particularly in Latin America and the Caribbean (LAC). Surveillance about the distribution of serotypes causing IPD and the impact of pneumococcal vaccination is an important epidemiological tool to monitor disease activity trends, inform public health decision-making, and implement relevant prevention and control measures. Objectives To estimate the serotype distribution for IPD and the related disease burden in LAC before, during, and after implementing the pneumococcal vaccine immunization program in LAC. Methods Systematic literature review following Cochrane methods of studies from LAC. We evaluated the impact of the pneumococcal vaccine on hospitalization and death during or after hospitalizations due to pneumococcal disease and serotype-specific disease over time. We also analyzed the incidence of serotyped IPD in pneumococcal conjugate vaccine PCV10 and PCV13. The protocol was registered in PROSPERO (ID: CRD42023392097). Results 155 epidemiological studies were screened and provided epidemiological data on IPD. Meta-analysis of invasive diseases in children <5 years old found that 57%-65% of causative serotypes were included in PCV10 and 66%-84% in PCV13. After PCV introduction, vaccine serotypes declined in IPD, and the emergence of non-vaccine serotypes varied by country. Conclusions Pneumococcal conjugate vaccines significantly reduced IPD and shifted serotype distribution in Latin America and the Caribbean. PCV10/PCV13 covered 57–84% of serotypes in children under 5, with marked decline in PCV serotypes post-vaccination. Continuous surveillance remains crucial for monitoring evolving serotypes and informing public health action.

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Invasive pneumococcal disease in children with cancer: Incidence density, risk factors and isolated serotypes

Cited by 4 publications

References 28 publications

Pediatric Invasive Pneumococcal Disease (IPD) in Yogyakarta, Indonesia: A Case Series

Pediatric Invasive Pneumococcal Disease (IPD) in Yogyakarta, Indonesia: A Case Series

Chronic medical conditions associated with invasive pneumococcal diseases in inpatients in teaching hospitals in São Paulo city: Estimating antimicrobial susceptibility and serotype-coverage of pneumococcal vaccines

Invasive pneumococcal disease in Latin America and the Caribbean: Serotype distribution, disease burden, and impact of vaccination. A systematic review and meta-analysis

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