Pediatric Invasive Pneumococcal Disease (IPD) in Yogyakarta, Indonesia: A Case Series

Abstract

Given the fact that invasive pneumococcal disease (IPD) has a high clinical burden, particularly among children in developing countries, data on its occurrence and clinical profile in Indonesia is still insufficient. We presented 3 cases of IPD in children who were admitted to Dr. Sardjito General Hospital, Yogyakarta, Indonesia between 2016 and 2019. While our first 2 patients had milder course of disease, our third patient who presented with meningoencephalitis had poor outcome. Risk factors shown in our cases were young age and malignancy history. Multiple antibiotic resistance was observed in our isolates. The fact that none of our patients have received pneumococcal vaccination marks the necessity of this vaccine especially for at-risk children.

A case series of invasive pneumococcal disease in children

“…In developing countries, the disease burden is high, and mortality rates are higher than in high-income countries. 4 Invasion of the host is affected by a number of factors. Nonspecific defence mechanisms, including the presence of other bacteria in the nasopharynx, may limit multiplication of Pneumococci.…”